 | | Vol. 8.10 – 27 March, 2023 |
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| The authors showed that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) was critical to muscle health.
[Nature Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The structure and function of mitochondria was disrupted in Mrps5 mutant cardiomyocytes, impairing mitochondrial protein translation, and OXPHOS.
[Nature Communications] |
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| Researchers demonstrated that doxorubicin challenge exhibited reduced contractile function and induction of ferroptosis-related phenotype in cardiomyocytes, evidenced by iron overload, lipid peroxide accumulation, and mitochondrial dysfunction.
[Advanced Science] |
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| Scientists determined whether patient plasma confered indirect phenotypic, transcriptional, and/or epigenetic alterations to ex vivo cardiomyocytes to mirror the failing human myocardium.
[Basic Research in Cardiology] |
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| Investigators demonstrated that the large Maf transcription factor family dictates fast type IIb myofiber specification in mice.
[Cell Reports] |
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| Researchers established a workflow using induced pluripotent stem cells (iPSC)-derived fibroblasts and skeletal myocytes for urethral tissue regeneration. Cells from voided urine of women were reprogrammed into iPSC.
[Scientific Reports] |
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| Scientists uncovered a new mechanism of immune modulation operating during skeletal muscle regeneration that was disrupted in aged animals and relied on the regulation of macrophage function.
[Nature Aging] |
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| To probe the role of smooth muscle cell (SMC)-derived hepcidin in the setting of abdominal aortic aneurysm (AAA), the authors applied Angiotensin-II-induced AAA model to mice harboring an inducible, SMC-specific deletion of hepcidin.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| The expression of Brahma related gene 1 (BRG1) was examined in high phosphorus stimulated rat aortic smooth muscle cells and calcified artery tissues from rat models and hemodialysis patients.
[iScience] |
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| Investigators identified whether the N6 methyladenosine writer METTL3/METTL4 regulated rip3 mRNA expression in abdominal aortic aneurysms.
[Journal of Cell Communication and Signaling] |
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Scientists summarize the reprogramming of fibroblasts into induced pluripotent stem cell-derived cardiomyocytes, induced cardiac progenitor cells, and induced cardiomyocytes to repair a damaged heart, and outline recent findings in utilizing fibroblast-derived cells for heart regeneration.
[Journal of Molecular and Cellular Cardiology] |
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| Amicus Therapeutics announced that the European Commission has granted approval for Pombiliti™, a long-term enzyme replacement therapy used in combination with miglustat for adults with late-onset Pompe disease.
[Amicus Therapeutics] |
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| July 24 – 28, 2023
Boston, Massachusetts, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Columbia University – New York, New York, United States |
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| | Hannover Medical School – Hanover, Germany |
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