 | | Vol. 8.11 – 3 April, 2023 |
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| Mitochondrial DNA (mtDNA) was administrated into isolated cardiomyocytes. Myocardial infarction was conducted in wild type and Z-DNA binding protein 1 (ZBP1) knockout mice.
[Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| RNA binding protein with multiple splicing (RBPMS) loss specifically and severely impeded cardiac mesoderm specification, leading to patterning and morphogenetic defects in human cardiac organoids.
[Science Advances] |
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| Scientists found that circCDYL2 derived from chromodomain Y-like 2 (Cdyl2) was significantly upregulated in vitro in oxygen-glucose deprivation-treated cardiomyocytes, and in vivo in failing heart post-myocardial infarction.
[Experimental & Molecular Medicine] |
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| Researchers infected primary cardiomyocytes and primary cardiac fibroblasts with wild-type and cell-death suppressor deficient mutant cytomegaloviruses (CMVs) to determine how CMV regulates necroptosis and apoptosis in cardiac cells.
[Cell Death Discovery] |
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| Using de novo–grown microtissues, scientists identified crucial actors of the mechanoregulated events, which iteratively orchestrated a sharp transition from tissue growth to maturation, requiring a myofibroblast-to-fibroblast transition.
[Science Advances] |
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| Researchers found that ubiquitin-specific protease 18 (USP18) depletion altered the calcium channel gene network, resulting in reduced calcium flux in myotubes. The reduced expression of sarcomeric proteins in the USP18 proteome was consistent with reduced contractile force in an engineered muscle model.
[Cell Death & Disease] |
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| The authors investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external, or internal conditions on Earth.
[NPJ Microgravity] |
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| Plating of wild-type vascular smooth muscle cells (SMCs) on FN decreased contractile gene expression and activated inflammatory pathways, whereas α5/2 SMCs were resistant.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| Immunohistochemical studies confirmed the expression of oxidants, antioxidants, and smooth muscle cell differentiation markers and their changes during the progression of thrombus organization.
[Journal Of Atherosclerosis And Thrombosis] |
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| The authors review the potential mechanisms that contribute to the reduction in major adverse cardiovascular events in individuals treated with glucagon-like peptide 1 receptor (GLP1R) agonists, and highlight the emerging cardiovascular biology of novel GLP1-based multi-agonists currently in development.
[Nature Reviews Cardiology] |
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| Scientists summarize emerging concepts about metabolic landscapes of cardiac aging, with specific focuses on why metabolic profile alters during cardiac degeneration and how the current knowledge can be utlized to improve the management of cardiac aging.
[Signal Transduction And Targeted Therapy] |
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| Abcuro, Inc. announced initiation of a registrational Phase II/III study of ABC008 in inclusion body myositis. ABC008 is a first-in-class anti-KLRG1 antibody capable of selectively depleting highly cytotoxic T cells, while sparing regulatory and central memory T cells.
[Abcuro Inc.] |
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| April 24 – 26, 2023
Hinxton, England, United Kingdom |
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| | The University of Utah – Salt Lake City, Utah, United States |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | Columbia University – New York, New York, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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