 | | Vol. 8.12 – 10 April, 2023 |
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| Scientists generated self-organizing human induced pluripotent stem cell-derived epicardioids that displayed retinoic acid-dependent morphological, molecular, and functional patterning of the epicardium and myocardium typical of the left ventricular wall.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators posited epicardial fibronectin as a mediator of epicardial-cardiomyocyte crosstalk and assessed its role in driving human pluripotent stem cell-derived cardiomyocyte maturation in 3D-engineered heart tissues
[Stem Cell Reports] |
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| Investigators elucidated whether L-carnitine protected H9c2 cells and its underlying mechanisms. Cell counting kit-8 assay was used to evaluate cell viability. Apoptosis, cell morphology, and lactate dehydrogenase assessment were used to prove effects of lipopolysaccharide and LC on H9c2 cells.
[Molecular Biotechnology] |
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| Investigators fabricated biofunctional cell-laden structures including methacrylated gelatin, collagen, and decellularized extracellular matrix. In vivo regenerative potential was observed in volumetric muscle defects in a mouse model.
[NPJ Regenerative Medicine] |
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| The authors established a model of iron overload in L6 skeletal muscle cells and observed that iron enhanced cytochrome c release from depolarized mitochondria, assayed by immunofluorescent colocalization of cytochrome c with Tom20 and the use of JC-1, respectively.
[Cell Death & Disease] |
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| Investigators identified genes critical for the insulin resistance of skeletal muscle in type 2 diabetes mellitus based on the Gene Expression Omnibus database and in vitro cell experiments.
[ACS Biomaterials Science & Engineering] |
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| Researchers determined circRRAS2’s roles in the proliferation and myogenic differentiation of these cells. The results showed that circRRAS2 was expressed in several bovine tissues.
[Animal Biotechnology] |
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| | Investigators revealed human meniscus fibrosis initiated at E24 weeks. Smooth muscle cell cluster was identified in embryonic meniscus, and the combined analysis with previous data suggests smooth muscle cell in embryonic meniscus as precursors of progenitor cells in the mature meniscus.
[Advanced Science] |
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| Lipopolysaccharide was used to construct the in vitro model of sepsis in vascular smooth muscle cells. 17β estradiol and Daidzein were used for estrogen supplement therapy.
[Biochemical And Biophysical Research Communications] |
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| Improvements in the design of AAV vectors to enhance their cardiotropism and efficacy or, alternatively, the development of non-viral methods for nucleic acid delivery in cardiomyocytes are among the challenges ahead to progress cardiac regenerative therapies towards clinical application.
[Journal Of Molecular And Cellular Cardiology] |
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| Repairon together with the University Medical Center Göttingen and the University Medical Center Schleswig-Holstein and the German Center for Cardiovascular Research announced the completion of enrollment and follow-up of patients in the dose-finding cohort of the BioVAT-HF-DZHK20 Phase I/II trial.
[Repairon] |
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| Keshav Narayan Alagarsamy, a PhD candidate in the department of physiology and pathophysiology at Max Rady College of Medicine, won first place at the University of Manitoba’s Three Minute Thesis final on March 30.
[University of Manitoba] |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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| | The University of Utah – Salt Lake City, Utah, United States |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | Columbia University – New York, New York, United States |
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