 | | Vol. 8.13 – 17 April, 2023 |
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| Using flow cytometry, immunohistochemistry, cardiac beating, transcriptional and ChIP qPCR assays, bulk RNAseq, and ATACseq analyses, FOXK1 was observed to be an important regulator of cardiogenesis.
[Cardiovascular Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) were generated using a 2D in vitro monolayer differentiation protocol. Human KCNJ2 construct with green fluorescent protein tag was created and overexpressed in iPSC-CMs via lentiviral transduction.
[Stem Cell Research & Therapy] |
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| Investigators assessed cardiomyocyte number, cell cycle activity, and ploidy dynamics across two divergent mouse strains: C57BL/6J and A/J.
[Development] |
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| The authors found that WD Repeat Domain 5 (WDR5) was required for the expression of double homeobox 4 (DUX4) and its targets in primary facioscapulohumeral muscular dystrophy muscle (FSHD) cells.
[Nucleic Acids Research] |
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| Scientists investigated the human skeletal muscle DNA methylome after exercise in low carbohydrate (CHO) energy balance compared with exercise in low-CHO energy deficit conditions.
[American Journal Of Physiology-Endocrinology And Metabolism] |
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| The saponin extract of the roots of Achyranthes bidentata was prepared and analyzed, and its activity on myoblast differentiation was assayed with C2C12 cell culture.
[Journal Of Ethnopharmacology] |
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| Investigators revealed a critical role of cardiac mesoderm enhancer-associated noncoding RNA, Carmn, a smooth muscle cell (SMC)-specific lncRNA, in regulating visceral SMC phenotype and contractility of the gastrointestinal tract.
[Gastroenterology] |
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| Mass spectrometry identified that fragile-X-related protein (FXR1) interacted with cytoskeletal proteins, particularly Arp2 and CYFIP1.
[Cell Reports] |
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| Investigators showed that endothelial cell senescence played a negative role in pulmonary hypertension via juxtacrine interaction with smooth muscle cells.
[iScience] |
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| Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA (lncRNA) that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines.
[Pathology – Research and Practice] |
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| Lipella Pharmaceuticals, Inc. has entered into a manufacturing collaboration agreement with Cook MyoSite, Inc. to facilitate Chemistry, Manufacturing, and Control documentation for Lipella’s drug candidate LP-10, aimed at treating hemorrhagic cystitis. LP-10 has been granted Orphan Drug Designation by the FDA.
[Lipella Pharmaceuticals (MarketScreener)] |
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| Meat and meat production are changing. In 2013, Dutch scientist Mark Post proved to the world that meat could be grown from stem cells extracted from a live animal, in a lab.
[Texas Monthly] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | European Molecular Biology Laboratory – Grenoble, France |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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