 | | Vol. 8.14 – 24 April, 2023 |
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| Investigators uncovered a mechanism that connects acylcarnitine accumulation to lipid intolerance, metabolic inflexibility, and respiratory inefficiency in skeletal muscle mitochondria.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that insufficient structural maturation of cardiomyocytes owing to trapping of transcription factor TEA domain transcription factor 1 (TEAD1) by mutant Lamin A/C at the nuclear membrane underlies the pathogenesis of Q353R-LMNA–related dilated cardiomyopathy.
[Science Advances] |
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| Researchers used cardiomyocyte-specific ChIP-seq of the activate enhancer marker P300 to identify 54,920 cardiomyocyte enhancers at seven stages of murine heart development.
[Developmental Cell] |
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| Scientists reported that engineering of Myomaker and Myomerger on the membrane of enveloped viruses leads to specific transduction of skeletal muscle.
[Cell] |
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| Investigators used fixed and live-cell imaging to study microtubule-based glucose transporter 4 (GLUT4) trafficking in human and mouse muscle fibers and L6 rat muscle cells.
[Elife] |
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| The authors systematically studied the underlying molecular mechanisms by which cucurbitacin IIb ameliorated muscle wasting in cancer cachexia both in vitro and in vivo.
[Phytotherapy Research] |
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| Mechanistically, AGGF1 enhanced the interaction between its receptor integrin α7 and latency-associated peptide-TGF-β1, blocks the cleavage of LAP-TGF-β1 to form mature TGF-β1, and inhibited Smad2/3 and ERK1/2 phosphorylation in vascular smooth muscle cells.
[Nature Communications] |
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| Investigators found that VSMCs-specific Prdm16 knockout mice already showed extensive changes in the expression of genes associated with extracellular matrix remodeling and inflammation in the abdominal aorta under normal housing conditions without any pathological stimuli.
[JCI Insight] |
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| Bioinformatics analysis showed that the Ras signaling pathway and exosomes (Exos) were crucial in pulmonary arterial hypertension (PAH). The PAH differential microRNAs (miRNAs) and miRNAs identified in endothelial progenitor cell-derived Exos were intersected to obtain miR-21-5p.
[European Journal of Pharmacology] |
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| Investigators present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma.
[European Respiratory Review] |
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| The authors highlight recent advances in muscle tissue engineering with a focus on recent strategies related to the regulation of vascularization and immune system response at the site of injury.
[Stem Cell Research & Therapy] |
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| Joeva Barrow, assistant professor of molecular nutrition in the Division of Nutritional Sciences in the College of Human Ecology, won a 2022 Hartwell Individual Biomedical Research Award, which funds scientists pursuing early stage, cutting-edge biomedical research to advance children’s health.
[Cornell University] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | University of Melbourne – Melbourne, Australia |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | European Molecular Biology Laboratory – Grenoble, France |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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