Muscle Cell News Volume 8.15 | May 1 2023

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    Noshin Noorjahan
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    2023-05-01 | MUSCN 8.15


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.15 – 1 May, 2023
    TOP STORY

    Polycomb Ezh1 Maintains Murine Muscle Stem Cell Quiescence through Non-Canonical Regulation of Notch Signaling

    Researchers reported that polycomb Ezh1 conferred quiescence to murine muscle stem cells (MuSCs) through a non-canonical function. In the absence of Ezh1, MuSCs spontaneously exited quiescence.
    [Developmental Cell]

    AbstractGraphical Abstract
    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff â„¢ and TeSR â„¢-AOF, presented by Kim Snyder. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Generation of Left Ventricle-Like Cardiomyocytes with Improved Structural, Functional, and Metabolic Maturity from Human Pluripotent Stem Cells

    Scientists exploited cardiac development knowledge to instruct differentiation of human pluripotent stem cells specifically toward left ventricle cardiomyocytes.
    [Cell Reports Methods]

    Full ArticlePress ReleaseGraphical Abstract

    JMJD6 Protects against Isoproterenol-Induced Cardiac Hypertrophy via Inhibition of NF-κB Activation by Demethylating R149 of the p65 Subunit

    Investigators demonstrated that jumonji C domain-containing protein 6 (JMJD6) overexpression significantly attenuated isoproterenol-induced hypertrophy in neonatal rat cardiomyocytes evidenced by the decreased cardiomyocyte surface area and hypertrophic genes expression.
    [Acta Pharmacologica Sinica]

    AbstractGraphical Abstract

    PCSK9 Inhibition Regulates Infarction-Induced Cardiac Myofibroblast Transdifferentiation via Notch1 Signaling

    In vitro studies showed that PCSK9i decreased the degree of fibrosis, migration, and collagen fiber deposition in cardiac fibroblasts.
    [Cell Biochemistry And Biophysics]

    Abstract

    The Asymmetrical ESR1 Signaling in Muscle Progenitor Cells Determines the Progression of Adolescent Idiopathic Scoliosis

    The authors revealed that Estrogen Receptor 1 (ESR1) expression declines in muscle stem/progenitor cells at the concave side ofAdolescent Idiopathic Scoliosis patients.
    [Cell Discovery]

    Full Article

    Single-Swap Editing for the Correction of Common Duchenne Muscular Dystrophy Mutations

    Investigators described single-swap editing in which an adenine base editor edits a single base pair at a splice donor site or splice acceptor site to enable exon skipping or reframing.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Hemoglobin Resident in the Lung Epithelium Is Protective for Smooth Muscle Soluble Guanylate Cyclase Function

    By conducting transwell co-culture with bronchial epithelial cells, A549/16-HBE, and human airway smooth muscle cells, researchers found that hemoglobin could protect the smooth muscle soluble guanylyl cyclase from excess nitric oxide.
    [Redox Biology]

    Full Article

    Lineage-Specific Induced Pluripotent Stem Cell–Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice

    Induced pluripotent stem cells were differentiated into aortic smooth muscle cells of the second heart field and neural crest lineages, enabling in vitro modeling of thoracic aortic aneurysm in Marfan syndrome.
    [Arteriosclerosis Thrombosis And Vascular Biology]

    Full Article

    HCMV-IE2 Promotes Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells’ Pyroptosis

    The infection models in vitro and in vivo were constructed to explore the pathogenesis of HCMV-related atherosclerosis.
    [Frontiers in Microbiology]

    Abstract
    Five tips for returning to the lab after time off
    REVIEWS

    Biological Functions of circRNAs and Their Advance on Skeletal Muscle Development in Bovine

    The authors summarized the current studies’ advance of circRNAs involved in skeletal muscle development in bovine, and hope to gain a deeper understanding of the functional roles of the circRNAs in muscle growth.
    [3 Biotech]

    Abstract
    INDUSTRY AND POLICY NEWS

    Unlocking a Cure for Heart Disease

    Funding totaling $23.6M has been announced to establish an international team—led by Dr. Michael Laflamme at UHN’s McEwen Stem Cell Institute—to develop cutting-edge regenerative therapies for heart disease.
    [University Health Network]

    Press Release
    FEATURED EVENT

    The Resistant Tumor Microenvironment

    May 7 – 10, 2023
    Vancouver, British Columbia, Canada

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Biological Sciences

    Birkbeck, University of London – London, England, United Kingdom

    Faculty Scientist Positions – Perioperative Medicine

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Fellow – Translational Physiology

    University of Melbourne – Melbourne, Australia

    Laboratory Manager – Muscle Sarcomeres

    European Molecular Biology Laboratory – Grenoble, France

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    > See All Jobs

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