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| Researchers engineered fibroblast growth factor 21 (FGF21) knock out mice and subsequently elucidated the effects of FGF21 and its downstream mediators using western blotting, qRT-PCR, and mitochondrial morphological and functional analyses. [Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated whether serum/glucocorticoid-regulated kinase 1 could similarly shorten action potential duration in long QT syndrome types 1 and 2. [Europace] |
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| Investigators studied the role of Nono in cardiomyocytes during development by utilizing the CRISPR/Cas9 gene editing system to deplete Nono in the rat cardiomyocytes H9c2. [Scientific Reports] |
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| Researchers suggested a critical role of histone deacetylase 1 (Hdac1) in maintaining both regular G1/S and G2/M phase transition in cardiomyocytes by controlling the expression of essential cell cycle regulators such as p21 and Cdc25. [Biochemical And Biophysical Research Communications] |
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| | Mass spectrometry imaging was used to show that injured muscles induced a specific subset of prostanoids during regeneration. The spike in prostacyclin promoted skeletal muscle regeneration via myoblasts and declined with aging. [Advanced Science] |
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| Scientists showed that ubiquitin-ligase NEDD4-1 targets the transcription factor PAX7 for proteasome-dependent degradation, promoting muscle differentiation in vitro. [Biological Research] |
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| Investigators determined if fibrosis occurs during cachexia development and evaluated in both sexes. In vitro analyses were also performed on cocultured C2C12 and 3T3 cells exposed to Lewis Lung Carcinoma conditioned media. [Cell Biochemistry And Function] |
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| Scientists investigated the effect and mechanism of metal responsive transcription factor 1 on the proliferation of pulmonary arterial smooth muscle cells. [Cell Cycle] |
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| Researchers identified POU2F2 and CEBPB as the main molecules that enhance endothelin 1 expression in male SHR vascular smooth muscle cells. [Journal Of Molecular Endocrinology] |
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| The authors review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. [Cell] |
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| More than 40 leading scientists have resigned en masse from the editorial board of a top science journal in protest at what they describe as the “greed” of publishing giant Elsevier. [The Guardian] |
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| May 23 – 25, 2023 Bar Harbor, Maine, United States & Virtual |
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| Cornell University – Ithaca, New York, United States |
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| Birkbeck, University of London – London, England, United Kingdom |
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| National Institutes of Health – Bethesda, Maryland, United States |
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| The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| University of Melbourne – Melbourne, Australia |
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