Muscle Cell News Volume 8.18 | May 29 2023

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    2023-05-29 | MUSCN 8.18


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.18 – 29 May, 2023
    TOP STORY

    Slo1 Deficiency Impaired Skeletal Muscle Regeneration and Slow-Twitch Fiber Formation

    To investigate the involvement of genes in the regulation of muscle dysfunction induced by Slo1 deletion, RNA-seq analysis was performed in primary myoblasts.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article
    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCultâ„¢-SF Expansion Supplement Kit (Human).
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Induces Cardiomyocyte Apoptosis and Inflammation but Can Be Ameliorated by ACE Inhibitor Captopril

    Scientists found that SARS-CoV-2 could infect cardiomyocytes and produce infectious progeny viruses in human pluripotent stem cell-derived cardiomyocyte-like cells.
    [Antiviral Research]

    Full ArticleGraphical Abstract

    Cardiomyocyte Nuclear Remodeling After Mechanical Unloading

    Investigators studied whether changes in DNA content with mechanical unloading occurred independent of cardiomyocyte proliferation by comparing human subjects undergoing left ventricular assist device implantation or primary transplantation.
    [American Journal Of Physiology-Heart And Circulatory Physiology]

    Abstract

    Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart

    Researchers investigated the role of senescence in regulating inflammation, fibrosis, and arrhythmogenesis in young and aged infarcted rabbits.
    [eLife]

    Abstract

    Non-Canonical Telomere Protection Role of FOXO3a of Human Skeletal Muscle Cells Regulated by the TRF2-Redox Axis

    Scientists showed in transformed fibroblasts and myotubes that the telomere properties of FOXO3a were dependent on the C-terminal segment of its CR2 domain but independent of its Forkhead DNA binding domain and of its CR3 transactivation domain.
    [Communications Biology]

    Full Article

    miR-136-5p/FZD4 Axis Is Critical for Wnt Signaling-Mediated Myogenesis and Skeletal Muscle Regeneration

    Investigators found that miR-136-5p was significantly upregulated during the proliferation and differentiation of C2C12 cells.
    [Journal Of Cellular Physiology]

    Abstract

    Bioinspired PLCL/Elastin Nanofibrous Vascular Tissue Engineering Scaffold Enhances Endothelial Cells and Inhibits Smooth Muscle Cells

    Cell culture experiments showed that a novel composite fiber membrane had high cell viability, promoting the proliferation and adhesion of human umbilical vein endothelial cells, and inducing a contractile phenotype in human umbilical artery smooth muscle cells.
    [Biomacromolecules]

    AbstractGraphical Abstract

    A High-Throughput 3D Cantilever Array To Model Airway Smooth Muscle Hypercontractility in Asthma

    Using DEFLCT, researchers exposed primary human airway smooth muscle cell-derived microtissues to a panel of six inflammatory cytokines present in the asthmatic niche, identifying TGF-β1 and IL-13 as inducers of a hypercontractile phenotype.
    [APL Bioengineering]

    Full Article

    MasR and pGCA Receptor Activation Protects Primary Vascular Smooth Muscle Cells and Endothelial Cells Against Oxidative Stress via Inhibition of Intracellular Calcium

    Investigators determined the effect of co-activation of MasR and particulate guanylate cyclase receptor (pGCA) pathways by synthesizing novel peptides in oxidative stress-induced vascular smooth muscle cells and endothelial cells.
    [Journal Of Cellular Biochemistry]

    Abstract
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Exercise Metabolism and Adaptation in Skeletal Muscle

    The authors provide a contemporary view of the metabolic flexibility and functional plasticity of skeletal muscle in response to exercise.
    [Nature Reviews molecular cell biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Lexicon Announces FDA Approval of InpefaTM (Sotagliflozin) for Treatment of Heart Failure

    Lexicon Pharmaceuticals, Inc. announced that the US FDA approved INPEFAâ„¢, a once-daily oral tablet to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults.
    [Lexicon Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    Single Cell Biology: From Development to Cancer

    June 18 – 22, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Position – Machine Learning Directed Design of Actuators from Biological Muscle

    ETH Zurich – Zurich, Switzerland

    Research Assistant – Inherited Cardiomyopathies

    University of Oxford – Oxford, England, United Kingdom

    Tenure Track Faculty & Associate Director – Cardiovascular Research

    Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Researcher – Molecular and Translational Cardiology

    Heidelberg University Hospital – Heidelberg, Germany

    Postdoctoral Researcher – Biological Sciences

    Birkbeck, University of London – London, England, United Kingdom

    > See All Jobs

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