Muscle Cell News Volume 8.19 | Jun 05 2023

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    2023-06-05 | MUSCN 8.19


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    Vol. 8.19 – 5 June, 2023
    TOP STORY

    Dual Human iPSC-Derived Cardiac Lineage Cell-Seeding Extracellular Matrix Patches Promote Regeneration and Long-Term Repair of Infarcted Hearts

    Scientists demonstrated the efficacy and mechanisms of mono- and dual-human pluripotent stem cell-derived cardiovascular progenitor cells- and cardiomyocytes-seeding small intestinal submucosal extracellular matrix for repair of infarcted hearts based on the side-by-side comparison.
    [Bioactive Materials]

    Full ArticleGraphical Abstract
    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human).
    PUBLICATIONSRanked by the impact factor of the journal

    Systematic Discovery of Transcription Factors That Improve hPSC-Derived Cardiomyocyte Maturation via Temporal Analysis of Bioengineered Cardiac Tissues

    Researchers performed temporal transcriptome RNAseq analyses of progressively matured human pluripotent stem cell-derived cardiomyocytes across 2D and 3D differentiation systems and further compared these bioengineered tissues to native fetal and adult-derived tissues.
    [APL Bioengineering]

    Full Article

    Empagliflozin Reduces Arrhythmogenic Effects in Rat Neonatal and Human iPSC-Derived Cardiomyocytes and Improves Cytosolic Calcium Handling at Least Partially Independent of NHE1

    Investigators studied whether the SGLT2 inhibitor empagliflozin affected cardiomyocyte electrical activity under hypoxic conditions using rat neonatal and human induced pluripotent stem cell-derived cardiomyocytes.
    [Scientific Reports]

    Full Article

    17-(R/S)-Hydroxyeicosatetraenoic Acid (HETE) Induces Cardiac Hypertrophy Through the CYP1B1 in Enantioselective Manners

    Researchers investigated the effect of 17-HETE enantiomers on cardiac hypertrophy and cytochrome P450 1B1 (CYP1B). Human adult cardiomyocyte cells were treated with 17-HETE enantiomers; cellular hypertrophy was evaluated by cell surface area and cardiac hypertrophy markers.
    [Prostaglandins & Other Lipid Mediators]

    Abstract

    Role of Mitochondria in the Myopathy of Juvenile Dermatomyositis and Implications for Skeletal Muscle Calcinosis

    A human skeletal muscle cell line, RH30, was used to generate an in vitro calcification model. Intracellular calcification was measured by flow cytometry and microscopy.
    [Journal Of Autoimmunity]

    Full ArticleGraphical Abstract

    ATF4 Regulates Mitochondrial Content, Morphology, and Function in Differentiating Skeletal Muscle Myotubes

    Scientists overexpressed and knocked down ATF4 in C2C12 myoblasts, differentiated them to myotubes for 5 days, and subjected them to acute or chronic contractile activity.
    [American Journal Of Physiology-Cell Physiology]

    Abstract

    Effects of Energy Drinks on Myogenic Differentiation of Murine C2C12 Myoblasts

    Investigators examined the in vitro effects of various energy drink brands on myogenic differentiation. Murine C2C12 myoblast cells were induced to differentiate into myotubes in the presence of one of eight energy drinks at varying dilutions.
    [Scientific Reports]

    Full Article

    miR-342-5p Promotes Vascular Smooth Muscle Cell Phenotypic Transition Through a Negative-Feedback Regulation of Notch Signaling via Targeting FOXO3

    miR-342-5p promoted vascular smooth muscle cell-phenotypic transition through a negative-feedback regulation of Notch signaling via downregulating FOXO3, which could be a potential target for cancer therapy.
    [Life Sciences]

    AbstractGraphical Abstract

    TM6SF2 Reduces Lipid Accumulation in Vascular Smooth Muscle Cells by Inhibiting LOX-1 and CD36 Expression

    Functional studies were conducted to investigate the role of TM6SF2 in lipid uptake and accumulation in human vascular smooth muscle cells using siRNA knockdown and overexpression techniques.
    [Experimental Cell Research]

    Abstract
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Vascular Smooth Muscle Cells in Intracranial Aneurysms

    The authors summarized the various phenotypes and functions of vascular smooth muscle cells (VSMCs) associated with intracranial aneurysm pathology. The possible influencing factors and potential molecular mechanisms of the VSMC phenotype switching were further discussed.
    [Microvascular Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    ‘It’s a Vote for Hope’: First Gene Therapy for Muscular Dystrophy Nears Approval, but Will It Work?

    On 22 June, the US FDA would decide whether to grant a fast-track approval to the first gene therapy for Duchenne muscular dystrophy, a genetic disorder that affects around 1 in 3,500 boys..
    [Nature]

    News Article

    Imbria Pharmaceuticals Completes Enrollment in Phase II IMPROVE-HCM Trial of Ninerafaxstat in Patients with Non-Obstructive Hypertrophic Cardiomyopathy

    Imbria Pharmaceuticals, Inc. announced that completed enrollment in the IMPROVE-HCM Phase II placebo-controlled clinical trial of ninerafaxstat with 67 patients with non-obstructive hypertrophic cardiomyopathy randomized.
    [Imbria Pharmaceuticals, Inc.]

    Press Release

    NIH Funding To Propel UT Southwestern Research Into Human Heart Regeneration

    Ongoing research at UT Southwestern Medical Center exploring the ability of human heart cells to regenerate after a heart attack or other cardiovascular event will be accelerated by a new award from the National Institutes of Health.
    [UT Southwestern Medical Center]

    Press Release
    FEATURED EVENT

    Advanced Cell and Tissue Biomanufacturing

    June 25 – 30, 2023
    Newry, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Studentship – Multi-Tissue Crosstalk Mediated by Exercise Induced Soluble Factors

    Loughborough University – Loughborough, England, United Kingdom

    PhD Position – Machine Learning Directed Design of Actuators from Biological Muscle

    ETH Zurich – Zurich, Switzerland

    Research Assistant – Inherited Cardiomyopathies

    University of Oxford – Oxford, England, United Kingdom

    Tenure Track Faculty & Associate Director – Cardiovascular Research

    Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Researcher – Molecular and Translational cardiology

    Heidelberg University Hospital – Heidelberg, Germany

    > See All Jobs

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