Muscle Cell News Volume 8.21 | Jun 19 2023

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    2023-06-19 | MUSCN 8.21


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.21 – 19 June, 2023
    TOP STORY

    iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy

    Investigators used a combination of induced pluripotent stem cell (iPSC)-based disease modeling and CRISPR/Cas9-mediated genome editing to generate patient-specific cardiomyocytes and isogenic controls lacking the pathogenic MYBPC3 variant.
    [Circulation Research]

    AbstractGraphical Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes

    Researchers investigated subcellular iron uptake mechanisms in patient-derived and CRISPR/Cas–edited induced pluripotent stem cell–derived cardiomyocytes, as well as in patient-derived heart tissue. They used an integrated platform of MS-DIA–based proteomics and signaling pathway interrogation.
    [Circulation Research]

    AbstractGraphical Abstract

    Tisp40 Prevents Cardiac Ischemia/Reperfusion Injury through the Hexosamine Biosynthetic Pathway in Male Mice

    Scientists showed that transcript induced in spermiogenesis 40 (Tisp40) expression, cleavage, and nuclear accumulation were increased by cardiac ischemia/reperfusion (I/R) injury. Overexpression of nuclear Tisp40 was sufficient to attenuate cardiac I/R injury in vivo and in vitro.
    [Nature Communications]

    Full Article

    Cardiomyocyte Peroxisome Proliferator-Activated Receptor α Prevents Septic Cardiomyopathy via Improving Mitochondrial Function

    Peroxisome proliferator-activated receptor (Ppara) disruption in cardiomyocytes augmented mitochondrial dysfunction, as revealed by damaged mitochondria, lowered ATP contents, decreased mitochondrial complex activities, and increased DRP1/MFN1 protein levels.
    [Acta Pharmacologica Sinica]

    Abstract

    Restoration of CPEB4 Prevents Muscle Stem Cell Senescence during Aging

    Investigators provided a proteomic analysis of physiologically aged murine muscle stem cells (MuSCs), illustrating a pre-senescent proteomic signature. During aging, the mitochondrial proteome and activity were impaired in MuSCs.
    [Developmental Cell]

    Full ArticlePress ReleaseGraphical Abstract

    The Dorsal Portion of the Bovine Diaphragm as a Useful Tissue for Producing a 3D Muscle Scaffold

    Researchers presented a muscular organoid produced from the bovine diaphragm, which had a peculiar multilayered structure with different fiber orientations depending on the considered area.
    [Journal Of Anatomy]

    Abstract

    Vascular Protection Afforded by Zinc Supplementation in Human Coronary Artery Smooth Muscle Cells Mediated by NRF2 Signaling Under Hypoxia/Reoxygenation

    Scientists compared the effects of zinc chelation or supplementation on total intracellular zinc content, antioxidant nuclear factor erythroid 2-related factor 2 (NRF2) targeted gene transcription, and hypoxia/reoxygenation-induced reactive oxygen species generation.
    [Redox Biology]

    Full Article

    Arginase 1 and L-Arginine Coordinate Fetal Lung Development and the Initiation of Labor in Mice

    Treatment of human myometrial smooth muscle cells with L-arginine significantly inhibited spontaneous contractions by attenuating activation of NF-κB and downregulating the expression of contraction-associated protein genes.
    [EMBO Reports]

    AbstractGraphical Abstract

    Osteopontin Is a Key Regulator of Vascular Smooth Muscle Cell Proliferation in the Outflow Vein of Arteriovenous Fistulas

    Scientists identified key factors associated with arteriovenous fistula outflow stenosis. They isolated vascular smooth muscle cells (VSMCs) from the inferior vena cava of wild-type and osteopontin-knockout mice and assessed the proliferation of VSMCs following stimulation with platelet-derived growth factors.
    [Microvascular Research]

    Full ArticleGraphical Abstract
    View tips on how to share lab duties effectively.
    REVIEWS

    Is It Time for Genetic Modifiers to Predict Prognosis in Duchenne Muscular Dystrophy?

    The authors review genetic modifier studies in Duchenne muscular dystrophy to date and discuss the effect of genetic modifiers on predicting disease trajectories, clinical trial design and interpretation, and therapeutic approaches.
    [Nature Reviews Neurology]

    Abstract

    Mitochondria Spatially and Temporally Modulate VSMC Phenotypes via Interacting with Cytoskeleton in Cardiovascular Diseases

    Investigators review vascular smooth muscle cell (VSMC) mitochondrial metabolism in three aspects: mitochondrial ROS generation, mutated mitochondrial DNA, and calcium metabolism respectively. They also summarize the role of mitochondrial dynamics in regulating VSMC phenotypes.
    [Redox Biology]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    CureDuchenne, Muscular Dystrophy Association, and Parent Project Muscular Dystrophy Announce Collaborative Project to Focus on Re-dosing Gene Therapy in Duchenne Muscular Dystrophy

    CureDuchenne, Muscular Dystrophy Association, and Parent Project Muscular Dystrophy, announced a collaborative clinical trial grant to test the repurposing of the FDA-approved drug Vyvgart, for its potential ability to reduce antibodies to adeno-associated virus in Duchenne muscular dystrophy patients.
    [CureDuchenne]

    Press Release
    FEATURED EVENT

    Amygdala Function in Emotion, Cognition, and Disease

    July 9 – 14, 2023
    Barcelona, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Skeletal Muscle Biology

    Monash University – Melbourne, Victoria, Australia

    Principal Scientist – RNA Therapeutics

    Novartis – Basel, Switzerland

    Postdoctoral Scholar – Neural Mechanisms of Cardiovascular & Metabolic Physiology

    University of Nevada – Reno, Nevada, United States

    PhD Studentship – Multi-Tissue Crosstalk Mediated by Exercise Induced Soluble Factors

    Loughborough University – Loughborough, England, United Kingdom

    PhD Position – Machine Learning Directed Design of Actuators from Biological Muscle

    ETH Zurich – Zurich, Switzerland

    > See All Jobs

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