Muscle Cell News Volume 8.22 | June 26 2023

June 26, 2023

2023-06-26 | MUSCN 8.22

Muscle Cell News by STEMCELL Technologies

Vol. 8.22 – 26 June, 2023

TOP STORY

Striated Muscle-Specific Base Editing Enables Correction of Mutations Causing Dilated Cardiomyopathy

The authors employed a combination of the viral vector AAVMYO with superior targeting specificity of heart muscle tissue and CRISPR base editors to repair patient mutations in the cardiac splice factor Rbm20, which caused aggressive dilated cardiomyopathy.
[Nature Communications]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Supramolecular Assemblies of Glycopeptides Enhance Gap Junction Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes via Inducing Spheroids Formation To Optimize Cardiac Repair

A supramolecular assembly of a glycopeptide containing a cell adhesion motif-RGD and saccharide-glucose was designed to enable the three-dimensional spheroid formation of human induced pluripotent stem cell-derived cardiomyocytes.
[Advanced Healthcare Materials]

Abstract

USF2 Activates RhoB/ROCK Pathway by Transcriptional Inhibition of miR-206 To Promote Pyroptosis in Septic Cardiomyocytes

Scientists investigated the role and mechanism of upstream stimulatory factor 2 (USF2) in septic cardiomyopathy (SCM). Serum samples were extracted from SCM patients and healthy individuals.
[Molecular and Cellular Biochemistry]

Abstract

Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p

Researchers investigated the potential role of the circ-insulin-like growth factor 1 receptor (circIGF1R) in the proliferation of cardiomyocytes.
[Dna And Cell Biology]

Abstract

SKELETAL MUSCLE CELLS

Hedgehog Signaling via Its Ligand DHH Acts as Cell Fate Determinant During Skeletal Muscle Regeneration

Using conditional mutagenesis and pharmacological Hedgehog (Hh) modulators in vivo and in vitro, investigators identified Desert Hh (DHH) as the key ligand that acted as a potent adipogenic brake by preventing the adipogenic differentiation of fibro/adipogenic progenitors.
[Nature Communications]

Full Article

PRMT5 Links Lipid Metabolism to Contractile Function of Skeletal Muscles

As adult muscles expressed high levels of protein arginine methyl transferase (PRMT5), scientists generated skeletal muscle-specific Prmt5 knockout mice.
[EMBO Reports]

Full Article Graphical Abstract

Decreased Expression of H19/miR-675 Ameliorates Muscle Atrophy by Regulating the IGF1R/Akt/FoxO Signaling Pathway

Hindlimb suspension of C57BL/6 mice and starvation of C2C12 cells with PBS were conducted to induce atrophy. Real-time PCR and Western blotting were used to measure the expression of RNAs and proteins.
[Molecular Medicine]

Full Article

RUNX1T1 Modulates Myogenic Differentiation by Regulating the Calcium Signaling Pathway and the Alternative Splicing of ROCK2

Investigators assessed the impact of runt-related transcription factor 1, translocated to 1 (RUNX1T1) on the proliferation and myogenic differentiation of goat primary myoblasts. It was observed that RUNX1T1 was highly expressed during the early stages of myogenic differentiation and the fetal stage.
[FASEB Journal]

Abstract

FKBP25 Regulates Myoblast Viability and Migration and Is Differentially Expressed in In Vivo Models of Muscle Adaptation

Scientists investigated potential roles for FKBP25 in myoblast viability, migration, and differentiation and in adaptation of mature skeletal muscle.
[FEBS Journal]

Abstract

SMOOTH MUSCLE CELLS

CircItgb5 Promotes Synthetic Phenotype of Pulmonary Artery Smooth Muscle Cells via Interacting with miR-96-5p and Uba1 in Monocrotaline-Induced Pulmonary Arterial Hypertension

High-throughput circRNAs sequencing was used to detect circItgb5 expression in control and platelet derived growth factors beta polypeptide b-treated pulmonary arterial smooth muscle cells.
[Respiratory Research]

Full Article

Circ_0008285 Silencing Suppresses Angiotensin II-Induced Vascular Smooth Muscle Cell Apoptosis in Thoracic Aortic Aneurysm via miR-150-5p/BASP1 Axis

Human vascular smooth muscle cells were treated with angiotensin II for functional experiments. Cell counting kit-8, 5-ethynyl-2′-deoxyuridine, and flow cytometry were applied for function analysis.
[Thoracic Cancer]

Full Article

More Airway Smooth Muscle in Males Versus Females in a Mouse Model of Asthma: A Blessing in Disguise?

BALB/c mice were exposed intranasally to either saline or house dust mite once daily for 10 consecutive days to induce experimental asthma.
[Experimental Physiology]

Full Article

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REVIEWS

Integrated Metabolic and Epigenetic Mechanisms in Cardiomyocyte Proliferation

Investigators summarize the current state of knowledge of metabolism and metabolite-mediated epigenetic modifications in cardiomyocyte proliferation, with a particular focus on highlighting the potential therapeutic targets that hold promise to treat human heart failure via metabolic and epigenetic regulations.
[Journal of Molecular and Cellular Cardiology]

Full Article

INDUSTRY AND POLICY NEWS

US FDA Approves First Anti-Inflammatory Drug for Cardiovascular Disease

AGEPHA Pharma USA, LLC announced that, following a Priority Review, the US FDA has approved LODOCO^® as the first anti-inflammatory atheroprotective cardiovascular treatment.
[AGEPHA Pharma]

Press Release

FEATURED EVENT

Muscle Cell News Volume 8.22 | June 26 2023

Striated Muscle-Specific Base Editing Enables Correction of Mutations Causing Dilated Cardiomyopathy

Supramolecular Assemblies of Glycopeptides Enhance Gap Junction Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes via Inducing Spheroids Formation To Optimize Cardiac Repair

USF2 Activates RhoB/ROCK Pathway by Transcriptional Inhibition of miR-206 To Promote Pyroptosis in Septic Cardiomyocytes

Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p

Hedgehog Signaling via Its Ligand DHH Acts as Cell Fate Determinant During Skeletal Muscle Regeneration

PRMT5 Links Lipid Metabolism to Contractile Function of Skeletal Muscles

Decreased Expression of H19/miR-675 Ameliorates Muscle Atrophy by Regulating the IGF1R/Akt/FoxO Signaling Pathway

RUNX1T1 Modulates Myogenic Differentiation by Regulating the Calcium Signaling Pathway and the Alternative Splicing of ROCK2

FKBP25 Regulates Myoblast Viability and Migration and Is Differentially Expressed in In Vivo Models of Muscle Adaptation

CircItgb5 Promotes Synthetic Phenotype of Pulmonary Artery Smooth Muscle Cells via Interacting with miR-96-5p and Uba1 in Monocrotaline-Induced Pulmonary Arterial Hypertension

Circ_0008285 Silencing Suppresses Angiotensin II-Induced Vascular Smooth Muscle Cell Apoptosis in Thoracic Aortic Aneurysm via miR-150-5p/BASP1 Axis

More Airway Smooth Muscle in Males Versus Females in a Mouse Model of Asthma: A Blessing in Disguise?

Integrated Metabolic and Epigenetic Mechanisms in Cardiomyocyte Proliferation

US FDA Approves First Anti-Inflammatory Drug for Cardiovascular Disease

Angiogenesis and Angiostability in Development, Disease, and Engineered Tissues

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Postdoctoral Research Associate – Medicine

Postdoctoral Position – ECM-Directed Musculoskeletal Development

Associate Director – Basic and Early Translational Research

Postdoctoral Research Fellow – Skeletal Muscle Biology

Postdoctoral Scholar – Neural Mechanisms of Cardiovascular & Metabolic Physiology

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