 | | Vol. 8.23 – 10 July, 2023 |
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| Researchers demonstrated that light-activated molecular machines—molecules that performed mechanical work on the molecular scale—could remotely stimulate intercellular calcium waves.
[Nature Nanotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Conductive biohybrid platforms were engineered by blending collagen type I and 2D MXene and afterwards, covalently crosslinking, to harness the biofunctionality of the protein component and the increased stiffness and enhanced electrical conductivity that two-dimensional titanium carbide provides.
[npj 2D Materials and Applications] |
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| The authors established an acute myocardial infarction (AMI) model in rats. They determined the effects of ginsenoside Rh2 on AMI by examining the myocardial infarct area, while regulation of myocardial pyroptosis was determined by assessing related factors.
[Clinical and Experimental Hypertension] |
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| To study the potential role of the nuclear envelope transmembrane protein 39 (Net39) gene in adulthood, scientists generated a muscle-specific conditional knockout of Net39 in mice.
[Journal Of Clinical Investigation] |
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| In human skeletal muscle, investigators observed that markers of oxidative fibers and mitochondria correlated positively with expression levels of PPARGC1A and CDK4 and negatively with expression levels of CDKN2A.
[Journal Of Clinical Investigation] |
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| Researchers showed that DNA-PKcs affected myogenesis independently of its role in double-strand break (DSB) repair. Consequently, this process did not require the accumulation of DSBs and it was also independent of caspase-induced DNA damage.
[Cell Death & Differentiation] |
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| Scientists showed that poor regeneration of juvenile D2-mdx muscles was associated with an enhanced inflammatory response to muscle damage that failed to resolve efficiently and supported the excessive accumulation of fibroadipogenic progenitors.
[Cell Death Discovery] |
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| Using C2C12 mouse myogenic cells, investigators found that Zinc-finger E-box binding homeobox 1 (Zeb1) and Transducin-like Enhancer of Split 3 (Tle3) proteins were crucial trans-factors that interacted and differentially regulated Myh3 expression.
[FASEB Journal] |
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| | The authors induced in vivo rat model of chronic kidney disease using a high adenine and phosphate diet to explore the relationship among aldosterone, mineralocorticoid receptor, H19, and vascular calcification.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| Researchers examined the effects of keratose hydrogels on c-kit+/CD31− cardiac vascular smooth muscle progenitor cell differentiation and the therapeutic potential of the resultant vascular smooth muscle cells in a mouse hindlimb ischemic model of peripheral artery disease.
[Stem Cell Reviews and Reports] |
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| Cystine deprivation and imidazole ketone erastin were used to induce vascular smooth muscle cell ferroptosis. Two different knockdown plasmids targeting P300 and A-485 were used to investigate the function of P300 in the ferroptosis of human aortic smooth muscle cells.
[Molecular Medicine] |
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| Scientists established smooth muscle cell-specific Dickkopf-1 (DKK1)-knockout mice by crossbreeding DKK1flox/flox mice with TAGLN-Cre mice.
[FASEB Journal] |
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| Investigators summarize the currently approved as well as the most promising therapeutics undergoing clinical trials aimed toward treating Duchenne muscular dystrophy with a focus on its cardiac manifestations.
[Therapeutic Advances in Neurological Disorders] |
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| US regulators passed lab-grown meat, making the country only the second in the world to move this food to market. Two companies, UPSIDE Foods in Berkeley and GOOD Meat have the green light to sell their cultivated chicken.
[Nature] |
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| August 6 – 11, 2023
South Hadley, Massachusetts, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Florida – Gainesville, Florida, United States |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | University of Colorado Boulder – Boulder, Colorado, United States |
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| | National Heart, Lung, & Blood Institute – Bethesda, Maryland, United States |
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