 | | Vol. 8.24 – 17 July, 2023 |
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| Tissue-engineered vascular grafts were developed using a low-cost technique that aligne dendothelial cells axially and smooth muscle cells circumferentially within hours.
[ACS Applied Materials & Interfaces] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Loss- and gain-of-function approaches were used to investigate the role of mitofusin 2 (MFN2) in cardiac response to hypobaric hypoxia.
[Acta Physiologica] |
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| The effects of miR-494-3p on HL-1 contained in pirarubicin (THP) were investigated by CCK8, flow cytometry, ROS detection, JC-1 mitochondrial membrane potential detection, TUNEL cell apoptosis detection, RT-qPCR, and Western blot.
[Environmental Toxicology] |
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| A hypoxia/reoxygenation model with H9c2 cells closely simulating myocardia ischemia/reperfusion injury was used as a cellular model. Scientists investigated the effects and mechanism underlying neferine on H9c2 cells in response to ischemia/reperfusion stimulation.
[Journal of Biochemical and Molecular Toxicology] |
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| Results showed, in vitro, that mechanical stretch could induce oxidative damage to myoblasts and trigger ferroptosis.
[Cell Death Discovery] |
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| To understand the changes in gene expression that occur as a result of aging in skeletal muscles, researchers generated a multi-time-point gene expression signature throughout the lifespan of mice and rats.
[Skeletal Muscle] |
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| Scientists found that the compartments had different proportions of slow-fast muscle fibers, corresponding to the functional differences between the superior compartment as an early-onset internal rotator and the inferior compartment as a durable stabilizer of the glenohumeral joint.
[Scientific Reports] |
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| The in vitro functions of lncRNA were analyzed by CCK-8 assays, EdU assays, scratch wound assays, Transwell assays, qRT-PCR analyses and Western blot analyses. RNA fluorescence in situ hybridization, immunoprecipitation, and mRNA microarrays were used to explore the underlying mechanism.
[Atherosclerosis] |
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| Researchers hypothesized that dimethylarginine dimethylaminohydrolase-1 (DDAH1) knockdown in human pulmonary microvascular endothelial cells would result in lower nitric oxide (NO) production, decreased apoptosis, and greater proliferation of human pulmonary arterial smooth muscle cells.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Vascular nitric oxide (NO) resistance is a common state in type 2 diabetes (T2D) associated with developing cardiovascular events and death. The authors summarize experimental and human evidence of vascular NO resistance in T2D and discuss its underlying mechanisms.
[Cell Death & Disease] |
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| SOLVE FSHD announced that it has awarded grants totalling USD $1.4M to four new collaborative research projects that address critical gaps in FSHD therapeutics, biology and/or biomarkers.
[SOLVE FSHD] |
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| August 3, 2023
New York, New York, United States |
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| | Icahn School of Medicine – New York City, New York, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Florida – Gainesville, Florida, United States |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | University of Colorado Boulder – Boulder, Colorado, United States |
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