Muscle Cell News Volume 8.25 | July 24 2023

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    Noshin Noorjahan
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    2023-07-24 | MUSCN 8.25


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.25 – 24 July, 2023
    TOP STORY

    Mislocalization of Pathogenic RBM20 Variants in Dilated Cardiomyopathy Is Caused by Loss-of-Interaction with Transportin-3

    Researchers demonstrated that mislocalized RBM20 arginine/serine-rich domain variants retained their splice regulatory activity, which revealed that aberrant cellular localization was the main driver of their pathological phenotype.
    [Nature Communications]

    Full ArticlePress Release
    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCultâ„¢-SF Expansion Supplement Kit (Human).
    PUBLICATIONSRanked by the impact factor of the journal

    Clearance of Defective Muscle Stem Cells by Senolytics Restores Myogenesis in Myotonic Dystrophy Type 1

    Using myotonic dystrophy type 1 patients’ samples, scientists showed that muscle stem cells/myoblasts exhibited signs of cellular senescence in vitro and in situ.
    [Nature Communications]

    Full Article

    Cooperative Regulation of Zhx1 and hnRNPA1 Drives the Cardiac Progenitor-Specific Transcriptional Activation during Cardiomyocyte Differentiation

    Investigators reported that the zinc fingers and homeoboxes 1 (Zhx1) protein, transiently expressed during the cell fate transition from mesoderm to cardiac progenitors, was indispensable for the proper cardiomyocyte differentiation of mouse and human embryonic stem cells.
    [Cell Death Discovery]

    Full Article

    Opposing Gene Regulatory Programs Governing Myofiber Development and Maturation Revealed at Single Nucleus Resolution

    The authors generated a combined multi-omic single-nucleus RNA-seq and ATAC-seq atlas of mouse skeletal muscle development at multiple stages of embryonic, fetal, and postnatal life.
    [Nature Communications]

    Full Article

    Cancer-Cell-Secreted Extracellular Vesicles Target p53 To Impair Mitochondrial Function in Muscle

    Researchers showed that extracellular vesicles secreted by breast cancer cells impair mitochondrial homeostasis and function in skeletal muscle, leading to decreased mitochondrial content and energy production and increased oxidative stress.
    [EMBO Reports]

    AbstractGraphical Abstract

    Kinin Receptors Regulate Skeletal Muscle Regeneration: Differential Effects for B1 and B2 Receptors

    Tibialis anterior muscles of kinin receptor knockout animals were subjected to traumatic injury. Myogenesis, angiogenesis, fibrosis, and muscle functioning were evaluated.
    [Inflammation Research]

    Full Article

    Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotypic Switch and Neointimal Formation by PRMT5

    The authors showed that protein arginine methyltransferase (PRMT) 5 was the most abundantly expressed PRMT in human aortic smooth muscle cells.
    [Cardiovascular Research]

    AbstractGraphical Abstract

    Sox10 Escalates Vascular Inflammation by Mediating Vascular Smooth Muscle Cell Transdifferentiation and Pyroptosis in Neointimal Hyperplasia

    Using single-cell RNA sequencing, scientists identified that macrophage-like vascular smooth muscle cells were the key cell population in mouse neointimal hyperplasia.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Cocaine Induces Vascular Smooth Muscle Cells Proliferation via DRP1-Mediated Mitochondrial Fission and PI3K/Hif-1α Signaling

    Researchers explored the effect of cocaine on the proliferation of vascular smooth muscle cells by in vitro experiments.
    [Biochemical and Biophysical Research Communications]

    Abstract
    Enjoy your weekend. Your cells will too. Reduce medium acidosis with mTeSRâ„¢ Plus.
    REVIEWS

    Deliberation on Debilitating Condition of Cancer Cachexia: Skeletal Muscle Wasting

    The authors elucidate the mechanisms involved in the skeletal muscle wasting phenomenon over the last few years and review different pathways responsible for muscle atrophy in cancer cachexia.
    [Fundamental & Clinical Pharmacology]

    Abstract
    INDUSTRY AND POLICY NEWS

    NIH Awards Will Fund Post-Treatment Lyme Disease Syndrome Research

    The National Institute of Allergy and Infectious Diseases has awarded five projects for research to better understand Post-treatment Lyme Disease Syndrome.
    [National Institutes of Health]

    Press Release
    FEATURED EVENT

    2023 Hormone-Dependent Cancers Conference GRC

    August 6 – 11, 2023
    Newry, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    Professor – Pharmacodynamics

    University of Florida – Gainesville, Florida, United States

    Postdoctoral/Research Scientists – Cardiovascular Biology

    Yale School of Medicine – New Haven, Connecticut, United States

    Postdoctoral Researcher – Contractile Protein Function in Heart & Skeletal Muscle Diseases

    Icahn School of Medicine – New York City, New York, United States

    Research Associate – Peripheral Neuromuscular System

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – ECM-Directed Musculoskeletal Development

    University of Colorado Boulder – Boulder, Colorado, United States

    > See All Jobs

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