 | | Vol. 8.26 – 31 July, 2023 |
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| Researchers developed a hydrogel ink containing prefabricated gelatin fibers to print 3D organ-level scaffolds that recapitulated the intra- and intercellular organization of the heart.
[Nature Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists observed the translocation of selected mitochondrial tricarboxylic acid cycle dehydrogenases to the nucleus as an adaptive stress response to anthracycline-cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes and in vivo.
[Nature Communications] |
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| Human induced pluripotent stem cell-derived cardiomyocytes were transfected with adenoviral MG53, in which the expression of MG53 can be controlled by doxycycline, and the cells were then exposed to H2O2 to mimic ischemia/reperfusion injury.
[Stem Cell Reviews and Reports] |
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| Investigators screened various cardiotoxic drugs and bromodomain and extraterminal inhibitors for their effects on GDF15 regulation in human cardiomyocytes and cancer cell lines and analyzed in-house and public gene signature databases.
[Scientific Reports] |
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| | Western blotting and quantitative real-time polymerase chain reaction approaches were adopted to analyze DJ-1 expression in skeletal muscle from aged humans or mice and compared with young subjects.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| The authors attempted to determine in older adults if metformin monotherapy during bed rest could reduce muscle fibrosis and cellular senescence/senescent associated secretory phenotype during the re-ambulation period.
[Aging Cell] |
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| Researchers determined if the consumption of a high-fat high-sucrose (HFS) diet, starting in the post-weaning period, led to changes in skeletal muscle morphology and mechanics after 14 weeks on the HFS diet.
[Scientific Reports] |
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| | Dual-luciferase reporter gene assay was performed to validate two competing endogenous RNA axes, hsa_circ_0001402/miR-183-5p/FKBP prolyl isomerase like and hsa_circ_0001402/miR-183-5p/beclin 1.
[Journal of Advanced Research] |
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| Investigators showed that circACTA2 was down-regulated in human intimal hyperplasia. circACTA2 overexpression in circACTA2 transgenic mice significantly decreased the neointimal hyperplasia induced by vascular injury.
[Cellular and Molecular Life Sciences] |
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| Non-dilated aortic samples were harvested intra-operatively from individuals with normal aortic valves or those with either predominant aortic stenosis or aortic regurgitation.
[Journal Of Thoracic And Cardiovascular Surgery] |
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| Using a pharmacological target network interaction analysis, 151 common targets and a protein–protein interaction network were identified containing the top 10 hub genes.
[Scientific Reports] |
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| The authors provide an overview of the unique features of skeletal muscle tissue, as well as its adaptability to exercise.
[Biomedical Journal] |
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| Researchers at Emory University will leverage the International Space Station National Laboratory to continue examining how microgravity affects the growth and function of cardiomyocytes as they mature into tissue-like structures.
[ISS National Lab] |
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| August 13 – 18, 2023
Andover, New Hampshire, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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| | Icahn School of Medicine – New York City, New York, United States |
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| | University of Colorado Boulder – Boulder, Colorado, United States |
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