Muscle Cell News Volume 8.27 | Aug 14 2023

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    Noshin Noorjahan
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    2023-08-14 | MUSCN 8.27


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.27 – 14 August, 2023
    TOP STORY

    Cardiomyocyte Proliferation Is Suppressed by ARID1A-Mediated YAP Inhibition during Cardiac Maturation

    Investigators showed that AT-rich interactive domain-containing protein 1a (Arid1a), a subunit of the switching defective/sucrose non-fermenting chromatin remodeling complex, suppressed postnatal cardiomyocyte proliferation while enhancing maturation.
    [Nature Communications]

    Full Article
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    Deubiquitinase JOSD2 Improves Calcium Handling and Attenuates Cardiac Hypertrophy and Dysfunction by Stabilizing SERCA2a in Cardiomyocytes

    Scientists explored the role and regulating mechanism of a deubiquitinating enzyme, Josephin domain-containing protein 2 (JOSD2), in cardiac hypertrophy.
    [Nature Cardiovascular Research]

    Abstract

    A Novel Small Molecule Inhibitor of p38⍺ MAP Kinase Augments Cardiomyocyte Cell Cycle Entry in Response to Direct Cell Cycle Stimulation

    Screening of small molecules with a potential to augment 4 cell cycle factor-induced cell-cycle induction in 60-day-old mature human induced pluripotent cardiomyocytes revealed N-(4,6-Dimethylpyridin-2-yl)-4-(pyridine-4-yl)piperazine-1-carbothioamide.
    [British Journal Of Pharmacology]

    Abstract

    Myonectin Protects against Skeletal Muscle Dysfunction in Male Mice through Activation of AMPK/PGC1α Pathway

    The authors investigated the effect of myonectin on skeletal muscle atrophy in various male mouse models of muscle dysfunction. Disruption of myonectin exacerbated skeletal muscle atrophy in age-associated, sciatic denervation-induced or dexamethasone-induced muscle atrophy models.
    [Nature Communications]

    Full Article

    Silver Electroceutical Technology to Treat Sarcopenia

    Scientists developed a high-throughput electrical stimulation screening platform that could simultaneously stimulate 15 independent conditions, while utilizing only a small number of human-derived primary aged/young skeletal muscle cells.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Disease Modeling and Gene Correction of LGMDR21- iPSCs Elucidates the Role of POGLUT1 in Skeletal Muscle Maintenance, Regeneration, and Satellite Cell Niche

    Using patient iPSCs, their corrected isotypes and control iPSCs, gene expression profiling indicated dysregulation of protein O-glucosyltransferase 1 (POGLUT1), NOTCH, muscle development, extracellular matrix, cell adhesion and migration, as involved pathways.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Muscle Specific ER-Associated Degradation Maintains Postnatal Muscle Hypertrophy and Systemic Energy Metabolism

    Researchers reported that the SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation complex, the primary molecular machinery that degraded misfolded proteins in the ER was vital to maintain postnatal muscle growth and systemic energy balance.
    [JCI Insight]

    AbstractFull Article

    CFTR Dysfunction in Smooth Muscle Drives TGFβ Dependent Airway Hyperreactivity

    Mice with smooth muscle-specific loss of cystic fibrosis transmembrane conductance regulator (CFTR) function were exposed to pulmonary transforming growth factor beta 1 (TGFβ).
    [Respiratory Research]

    Full Article

    Aortic Smooth Muscle TRPV4 Channels Regulate Vasoconstriction in High Salt-Induced Hypertension

    Researchers performed wire myograph experiments in isolated aortas from endothelial cell specific transient receptor potential vanilloid 4 (TRPV4) channel knockout mice.
    [Hypertension Research]

    AbstractGraphical Abstract

    Inhibition of Voltage-Dependent K+ Currents of Rabbit Coronary Arterial Smooth Muscle Cells by the Atypical Antipsychotic Paliperidone

    Investigators explored whether paliperidone inhibited the voltage-dependent K+ channels of rabbit coronary arterial smooth muscle cells.
    [Journal of Applied Toxicology]

    Abstract
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    REVIEWS

    Maturation of a Postsynaptic Domain: Role of Small Rho GTPases in Organizing Nicotinic Acetylcholine Receptor Aggregates at the Vertebrate Neuromuscular Junction

    The authors integrate evidence of key processes and molecules that have shed light on their current understanding of the neuromuscular junction maturation process.
    [Journal of Anatomy]

    Full Article
    INDUSTRY AND POLICY NEWS

    SIU Prof Gets $445K Grant for Genetic Research on a Devastating Childhood Cancer

    A researcher at Southern Illinois University Carbondale will use a $445,500 federal grant to explore ways of turning off a genetic switch that allows rare but devasting cancer to progress in children.
    [Southern Illinois University Carbondale]

    Press Release
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    October 2 – 4, 2023
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    JOB OPPORTUNITIES

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    Research Associate – Vascular Biology

    Newcastle University – Newcastle, England, United Kingdom

    Assistant/Associate/Full Professor – Pharmacodynamics

    University of Florida – Gainesville, Florida, United States

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

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