 | | Vol. 8.29 – 28 August, 2023 |
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| The authors built bioengineered platforms using genetically modified human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to model the early spatiotemporal process of cardiomyocyte junction assembly in vitro.
[Stem Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers performed RNA-seq and reduced representation bisulfite sequencing to profile the landscapes of bisphenol-induced cardiotoxicity and to determine the key roles of DNA methylation in the transcription.
[Ecotoxicology and Environmental Safety] |
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| Scientists investigated the effects of the kisspeptin receptor antagonist peptide-234 on the development of uremic cardiomyopathy.
[Scientific Reports] |
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| Researchers investigated the effects of repeated exposure to witness social defeat stress on cardiomyocyte contractile function and intracellular Ca2+ homeostasis in young adult wild-type Groningen female rats.
[Physiology & Behavior] |
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| The authors investigated the differences in SSC lineage tree and differentiation potential in neonatal and adult Tet1+/+ and Tet1-/- mice, with and without injury and upon osteoarthritis induction and progression.
[Arthritis & Rheumatology] |
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| Scientists explored the role of the endocannabinoid system during muscle toxicity induced by simvastatin.
[Cell Death & Disease] |
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| Investigators used skeletal muscle tissues from five patients with ryanodine receptor 1 (RYR1)-related congenital myopathy and compared those with five controls and five patients with RYR1-related rhabdomyolysis/myalgia.
[Acta Physiologica] |
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| Skeletal muscle satellite cells (SMSCs) were generated with stable knockdown and overexpression of circLRRFIP1, and the results showed that circLRRFIP1 exerted a stimulatory effect on the proliferation and differentiation of SMSCs.
[Poultry Science] |
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| | Researchers engineered a tubular decellularized extracellular matrix with an intact internal layer and bidirectional aligned microchannels in the tubular wall, which was realized by the subcutaneous implantation of a template, followed by the removal of the template, and decellularization.
[Advanced Healthcare Materials] |
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| Investigators showed that lurasidone inhibited the vascular voltage-gated K+ channels of rabbit coronary arterial smooth muscle cells in a dose-dependent manner with an IC50 of 1.88 ± 0.21 μM and a Hill coefficient of 0.98 ± 0.09.
[European Journal of Pharmacology] |
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| Scientists investigated the potential effect of Nemopilema nomurai jellyfish venom on cell migration, proliferation, and differentiation of vascular smooth muscle cells.
[Toxicon] |
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| Pulmonary artery smooth muscle cells were incubated with different concentrations of GW501516 under the hypoxic condition. The proliferation was determined by a CCK-8 assay.
[Current Medical Science] |
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| Skeletal muscle and adipose tissues are secretory organs that release secretory factors including cytokines and exosomes. These factors mediate muscle–adipose crosstalk to regulate systemic metabolism via paracrine and endocrine pathways.
[Trends In Endocrinology And Metabolism] |
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| The authors summarize fibro-adipogenic progenitors’ role in fibrosis in terms of their activation, heterogeneity, contributions to fibrotic degeneration, and role across musculoskeletal diseases.
[American Journal Of Physiology-Cell Physiology] |
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| Curi Bio announced two recent SBIR grants worth $4.4 million from the National Institutes of Health (NIH) to support its pioneering work on implementing human models to advance the discovery of the next generation of medicines.
[Curi Bio] |
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| October 4 – 6, 2023
Paris, France |
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| | University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | University of Florida – Gainesville, Florida, United States |
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