 | | Vol. 8.30 – 11 September, 2023 |
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| Using chemically modified mRNAs, researchers generated a panel of cardiogenic growth factors and tested their effects on enhancing cardiomyocyte and endothelial cell induction during different stages of human embryonic stem cell differentiations.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Muscle satellite cells from donors with peripheral artery disease were obtained during surgery. cDNA libraries were processed for single-cell RNA sequencing using the 10X Genomics platform.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| Researchers used BioID to interrogate the interactomes of β1 and β3 integrins in epithelial cells and identified PEAK1 as an interactor of the RGD-binding integrins α5β1, αVβ3, and αVβ5 in focal adhesions.
[Journal of Cell Biology] |
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| The authors used human induced pluripotent stem cell-derived (hiPSC) cardiomyocytes, endothelial cells, cardiac fibroblasts, multi-lineage cardiac spheroids, patient-specific hiPSCs, and multiple human cancer cell lines to compare the anticancer efficacy and reduced cardiotoxicity of single protein encapsulated doxorubicin, to standard unformulated doxorubicin.
[Stem Cell Reports] |
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| Changes in skeletal muscle morphology, myofibre composition, muscle niche cellular dynamics, DNA damage, proliferation, mitochondrial respiration, and metabolism and changes in progenitor cell fate were assessed.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| Investigators assesssed the effects of muscle-specific caveolin-3 deficiency on mammalian or mechanistic target of rapamycin complex 1 (mTORC1) signalling in skeletal muscle cells.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| TGS1 mediated macrophage inflammatory response induced the development of insulin resistance in skeletal muscle cells and adipocytes.
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] |
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| Scientists discovered that FAM3A, a newly identified metabolic cytokine, was decreased in the aortas and plasma in abdominal aortic aneurysm patients and murine models
[Nature Communications] |
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| Pharmacological inhibition of PFKFB3 using PFK15 or knockdown of PFKFB3 ameliorated vascular calcification in vD3-overloaded mice in vivo, or attenuated high phosphate-induced vascular smooth muscle cell calcification in vitro.
[FASEB Journal] |
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| Human aortic smooth muscle cells (HASMCs) were cultured. METTL3 was knocked down and overexpressed. Then, both METTL3 and NOTCH1 were simultaneously knocked down in HASMCs.
[Annals Of Translational Medicine] |
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| The author summarizes the growing evidence of bronchial epithelial cells and airway smooth muscle cells crosstalk under normal and pathophysiological conditions, first discussing the impact of airway smooth muscle cells on the epithelium in inflammatory settings.
[Heliyon] |
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| The new research projects are aimed at improving diagnosis, monitoring progression, and testing potential new treatments for muscle-wasting conditions.
[Muscular Dystrophy UK] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) – Bethesda, Maryland, United States |
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| | University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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