Muscle Cell News Volume 8.31 | Sep 18 2023

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    Noshin Noorjahan
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    2023-09-18 | MUSCN 8.31


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.31 – 18 September, 2023
    TOP STORY

    Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

    RNA-seq databases, NanoString nCounter, and cleavage under targets and release using nuclease were utilized to investigate histone acetylation, hyperacetylation targets, protein and gene expression, sphingolipid activation, cell proliferation, and gene target identification.
    [Circulation Research]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Cardiac Fibroblast GSK-3α Aggravates Ischemic Cardiac Injury by Promoting Fibrosis, Inflammation, and Impairing Angiogenesis

    To determine the role of fibroblast-glycogen synthase kinase-3 (GSK-3) α in myocardial infarction-induced adverse cardiac remodeling, GSK-3α was deleted specifically in the residential fibroblast or myofibroblast using tamoxifen inducible Tcf21 or Periostin promoter-driven Cre recombinase, respectively.
    [Basic Research In Cardiology]

    Abstract

    Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promote Angiogenesis through Alpha-B Crystallin

    Cardiomyocytes were differentiated from human induced pluripotent stem cells via monolayer culturing, and the cells were harvested on day 28 or 56 after differentiation.
    [Stem Cell Research & Therapy]

    Full Article

    SARS-CoV-2 Viral Genes Nsp6, Nsp8, and M Compromise Cellular ATP Levels to Impair Survival and Function of Human Pluripotent Stem Cell-Derived Cardiomyocytes

    Cardiomyocytes were derived from human pluripotent stem cells, including human embryonic stem cells and induced pluripotent stem cells, using 2D and 3D differentiation methods.
    [Stem Cell Research & Therapy]

    Full Article

    Hemifacial Myohyperplasia Is Due to Somatic Muscular PIK3CA Gain-of-Function Mutations and Responds to Pharmacological Inhibition

    To understand the physiopathology of muscle hypertrophy in the context of hemifacial myohyperplasia, scientists created a mouse model carrying specifically a PIK3CA mutation in skeletal muscles.
    [Journal Of Experimental Medicine]

    Abstract

    MATR3 Is an Endogenous Inhibitor of DUX4 in FSHD Muscular Dystrophy

    The authors identified Matrin 3 (MATR3), whose mutation caused amyotrophic lateral sclerosis and dominant distal myopathy, as a cellular factor controlling double homeobox 4 (DUX4) expression and activity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Bulk and Single-Cell Alternative Splicing Analyses Reveal Roles of TRA2B in Myogenic Differentiation

    Researchers employed isoform long-reads RNA-seq and single-cell RNA-seq to investigate the alternative splicing landscape during myogenesis.
    [Cell Proliferation]

    Full Article

    ANO1, CaV1.2, and IP3R Form a Localized Unit of EC-Coupling in Mouse Pulmonary Arterial Smooth Muscle

    Investigators used smooth muscle–specific ablation of Anoctamin-1 (ANO1) and pharmacological tools to establish the role of ANO1, CaV1.2, and IP3R in the contractile and intracellular Ca2+ signaling properties of mouse pulmonary arterial smooth muscle expressing the Ca2+ biosensor GCaMP3 or GCaMP6.
    [Journal Of General Physiology]

    Abstract

    MiR-590-3p Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells by Targeting LOX

    The authors investigated the clinical characteristics of patients with acute aortic dissection and miR-590-3p levels in serum, tissue, and vascular smooth muscle cells.
    [Journal of Cardiovascular Pharmacology]

    Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Interoceptive Regulation of Skeletal Tissue Homeostasis and Repair

    Scientists provide a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the central nervous system to maintain bone homeostasis and their potential role in pathological conditions.
    [Bone Research]

    Full Article

    A Review of Protocols for Engineering Human Cardiac Organoids

    Investigators highlight different strategies for generating human cardiac organoids using hPSCs while also critically discussing their challenges and limitations.
    [Heliyon]

    Full Article
    INDUSTRY AND POLICY NEWS

    Wexner Medical Center Among the First in the Nation to Administer New Gene Therapy for ALS

    The Ohio State University Wexner Medical Center is one of the first nationwide to administer a targeted gene therapy for patients with a specific form of amyotrophic lateral sclerosis, a neurodegenerative disease that affects the cells in the brain and spine.
    [Ohio State University]

    Press Release
    FEATURED EVENT

    ESMO Congress 2023

    October 20 – 24, 2023
    Madrid, Spain

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    JOB OPPORTUNITIES

    Open Rank Faculty – Pharmacology

    University of Houston – Houston, Texas, United States

    Assistant Professor – Cancer, Cardiovascular and Metabolic Health, or Brain, Mind, and Behavior

    Northwestern University – Chicago, Illinois, United States

    Scientific Director – Intramural Research Program

    National Institute of Arthritis and Musculoskeletal and Skin Diseases – Bethesda, Maryland, United States

    PhD Position – Molecular and Computational Neurogenomics

    VIB – Antwerp, Belgium

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    > See All Jobs

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