 | | Vol. 8.32 – 25 September, 2023 |
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| Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells (Tregs), their functional maturation, and a more pronounced decline in muscle mass.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the role of cellular adenosine in epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to ischemia/reperfusion (I/R). Evans blue/TTC staining and echocardiography were used to assess the extent of I/R injury in mice.
[Redox Biology] |
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| The active immunity method was used to establish a β1-AA-induced mouse cardiac dysfunction model, and RT-PCR and western blot were used to detect changes in gene and protein expression in cardiomyocytes.
[Cellular & Molecular Biology Letters] |
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| Researchers used db/db mice to simulate the animal model of diabetic cardiomyopathy and the expression of miR-200a-3p was then examined by RT-qPCR. Tail vein injection of mice was done with rAAV-miR-200a-3p for eight weeks, and cardiac function was assessed by cardiac ultrasound.
[Peerj Life & Environment] |
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| Exosome release inhibitor GW4869 was used to examine the effect of exosomes on intermittent hypoxia-induced AC16 cells apoptosis.
[Sleep And Breathing] |
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| Investigators revealed that Krüppel-like factor 4 (KLF4) played a critical role in skeletal muscle development and regeneration. Specific knockout of KLF4 in skeletal muscle impaired muscle formation further affecting physical activity and also defected skeletal muscle regeneration.
[Cell Death & Disease] |
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| Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.
[Communications Biology] |
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| Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced.
[Scientific Reports] |
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| | Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.
[Acta Pharmacologica Sinica] |
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| Using 18-22-week gestation human fetal airway smooth muscle as an in vitro model, the authors tested the hypothesis that mechanosensitive Piezo channels contributed to stretch effects.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| ApoE−/− mice with vascular smooth muscle cells-specific overexpression of liver kinase B1 (LKB1) were constructed by adeno-associated virus transfection technique, and then fed with a high-fat diet for eight weeks.
[International Journal Of Cardiology] |
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| The authors discuss how survival motor neuron (SMN) protein might regulate the health of myofibers and their progenitors. They also speculate on therapeutic outcomes of failing to raise muscle SMN to healthful levels and present strategies to restore function to this tissue to ensure better treatment results.
[JCI Insight] |
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| A national clinical consortium has joined forces to improve care outcomes for children born with congenital muscle disease, led by Monash University’s Professor Peter Currie.
[Monash University] |
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| October 22 – 25, 2023
Salt Lake City, Utah, United States |
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| | University of Houston – Houston, Texas, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Chinese Academy of Sciences – Shanghai, China |
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