Muscle Cell News Volume 8.34 | Oct 23 2023

October 23, 2023

2023-10-23 | MUSCN 8.34

Muscle Cell News by STEMCELL Technologies

Vol. 8.34 – 23 October, 2023

TOP STORY

Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development

Scientists investigated the functions and downstream mechanisms of neuregulin-1 (Nrg1) signaling during ventricular chamber development using confocal imaging, transcriptomics, and biochemical approaches in mice with cardiac-specific inactivation or overexpression of Nrg1.
[Circulation Research]

Abstract Graphical Abstract

Virtual Conference Exhibition: Organoids

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Translational Landscape of Direct Cardiac Reprogramming Reveals a Role of Ybx1 in Repressing Cardiac Fate Acquisition

Investigators characterized the translational landscape of induced cardiomyocyte reprogramming through integrative ribosome and transcriptomic profiling, and found extensive translatome repatterning during this process.
[Nature Cardiovascular Research]

Abstract

Del Nido Cardioplegia or Potassium Induces Nrf2 and Protects Cardiomyocytes against Oxidative Stress

The authors addressed whether cardioplegia was essential for cardiopulmonary bypass surgery activated Nrf2, a transcription factor regulating the expression of antioxidant and detoxification genes.
[American Journal Of Physiology-Cell Physiology]

Abstract

Engineered Heart Tissue Maturation Inhibits Cardiomyocyte Proliferative Response to Cryoinjury

Considering the lack of reliable in vitro tissue-like models to evaluate the molecular mechanisms of cardiac regeneration, scientists used cryoinjury on rat Engineered Heart Tissues as a new model which recapitulated in part the in vivo response after myocardial injury of neonatal and adult heart.
[Journal of Tissue Engineering]

Full Article Graphical Abstract

SKELETAL MUSCLE CELLS

Reprogramming of Cis-Regulatory Networks during Skeletal Muscle Atrophy in Male Mice

Using matched single-nucleus chromatin accessibility and RNA-sequencing from juvenile male C57BL6 mice, researchers showed an atlas of accessible chromatin regions in both normal and denervated skeletal muscles.
[Nature Communications]

Full Article

Intravital Microscopy of Satellite Cell Dynamics and Their Interaction with Myeloid Cells during Skeletal Muscle Regeneration

The authors developed a dual-laser multimodal nonlinear optical microscope platform to study the dynamics of muscle satellite cells and their interaction with nonmyogenic cells during muscle regeneration.
[Science Advances]

Full Article Press Release

Inherited Myogenic Abilities in Muscle Precursor Cells Defined by the Mitochondrial Complex I-Encoding Protein

Proteomic analysis was conducted to clarify the molecular differences between myoblasts derived from tibialis anterior and soleus.
[Cell Death & Disease]

Full Article

The Effect of Heat Stress on Heat Shock Protein Expression and Hypertrophy Related Signaling in the Skeletal Muscle of Trained Individuals

Scientists showed a single session of whole-body heat stress followed by resistance exercise increases the expression of heat shock protein A as well as activation of the Akt-mTOR cascade in skeletal muscle compared to resistance exercise in a healthy, resistance trained population.
[American Journal Of Physiology-Regulatory Integrative And Comparative Physiology]

Abstract

SMOOTH MUSCLE CELLS

Senolytics Prevent Caveolar Ca_V3.2-RyR Axis Malfunction in Old Vascular Smooth Muscle

Using vascular smooth muscle cells from mouse mesenteric arteries, researchers found that Ca²⁺ sparks were diminished after caveolae disruption by methyl-β-cyclodextrin in cells from dasatinib + quercetin treated but not vehicle-treated 14-month-old mice.
[Aging Cell]

Full Article

Extracellular SOD Modulates Canonical TNFα Signaling and α5β1 Integrin Transactivation in Vascular Smooth Muscle Cells

Scientists tested the hypothesis that extracellular superoxide dismutase (ecSOD) modified TNFα signaling in vascular smooth muscle cells. Knockdown of ecSOD suppressed downstream TNFα signals.
[Free Radical Biology and Medicine]

Abstract Graphical Abstract

Selenium Deficiency Promotes Dilatation of the Aorta by Increasing Expression and Activity of Vascular Smooth Muscle Cell Derived Matrix Metalloproteinase-2

C57BL/6N male mice were fed with a selenium (Se) deficient, Se adequate, or Se supplemented diet for eight weeks. Subsequently, an AA murine model was established using angiotensin II for four weeks plus β-aminopropionitrile for the first two weeks.
[European Journal Of Vascular And Endovascular Surgery]

Abstract

Resources for Your T Cell Therapy Research

REVIEWS

Traumatic Muscle Injury

Traumatic muscle injury can affect people across the lifespan and can result from high stresses and strains to skeletal muscle tissue, often due to muscle activation while the muscle is lengthening.
[Nature Reviews Disease Primers]

Abstract

Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis

The authors discuss the nine vascular smooth muscle cell (VSMC) phenotypes that have been reported in atherosclerotic lesions and classify them into differentiated VSMCs, intermediately dedifferentiated VSMCs, and dedifferentiated VSMCs.
[Journal Of The American Heart Association]

Full Article

INDUSTRY AND POLICY NEWS

Intellia Therapeutics Announces FDA Clearance of Investigational New Drug (IND) Application to Initiate a Pivotal Phase III Trial of NTLA-2001 for the Treatment of Transthyretin (ATTR) Amyloidosis with Cardiomyopathy

Intellia Therapeutics, Inc. announced that the US FDA has cleared the company’s IND application for NTLA-2001 for the treatment of ATTR amyloidosis with cardiomyopathy.
[Intellia Therapeutics, Inc. (GlobeNewswire)]

Press Release

FEATURED EVENT

Muscle Cell News Volume 8.34 | Oct 23 2023

Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development

Translational Landscape of Direct Cardiac Reprogramming Reveals a Role of Ybx1 in Repressing Cardiac Fate Acquisition

Del Nido Cardioplegia or Potassium Induces Nrf2 and Protects Cardiomyocytes against Oxidative Stress

Engineered Heart Tissue Maturation Inhibits Cardiomyocyte Proliferative Response to Cryoinjury

Reprogramming of Cis-Regulatory Networks during Skeletal Muscle Atrophy in Male Mice

Intravital Microscopy of Satellite Cell Dynamics and Their Interaction with Myeloid Cells during Skeletal Muscle Regeneration

Inherited Myogenic Abilities in Muscle Precursor Cells Defined by the Mitochondrial Complex I-Encoding Protein

The Effect of Heat Stress on Heat Shock Protein Expression and Hypertrophy Related Signaling in the Skeletal Muscle of Trained Individuals

Senolytics Prevent Caveolar Ca_V3.2-RyR Axis Malfunction in Old Vascular Smooth Muscle

Extracellular SOD Modulates Canonical TNFα Signaling and α5β1 Integrin Transactivation in Vascular Smooth Muscle Cells

Selenium Deficiency Promotes Dilatation of the Aorta by Increasing Expression and Activity of Vascular Smooth Muscle Cell Derived Matrix Metalloproteinase-2

Traumatic Muscle Injury

Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis

Intellia Therapeutics Announces FDA Clearance of Investigational New Drug (IND) Application to Initiate a Pivotal Phase III Trial of NTLA-2001 for the Treatment of Transthyretin (ATTR) Amyloidosis with Cardiomyopathy

Generation and Application of Organoid Disease Models

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Research Assistant – Neuromuscular Diseases

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Open Rank Faculty – Pharmacology

Assistant Professor – Cancer, Cardiovascular and Metabolic Health, or Brain, Mind, and Behavior

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