Muscle Cell News Volume 8.35 | Oct 30 2023

    By
    Noshin Noorjahan
    -
    0
    10








    2023-10-30 | MUSCN 8.35


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.35 – 30 October, 2023
    TOP STORY

    Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair

    Researchers used apical resection and myocardial infarction surgical models in neonatal and adult mice to investigate extracellular matrix components involved in heart regeneration after injury.
    [Circulation]

    Abstract
    Stay up-to-date with the latest stem cell research by listening to the Stem Cell Podcast!
    PUBLICATIONSRanked by the impact factor of the journal

    Titin Governs Myocardial Passive Stiffness with Major Support from Microtubules and Actin and the Extracellular Matrix

    Investigators targeted the cytoskeletal filaments in a mouse model, which enabled the specific, acute, and complete cleavage of the sarcomeric titin springs.
    [Nature Cardiovascular Research]

    Full Article

    The Multi-Lineage Transcription Factor ISL1 Controls Cardiomyocyte Cell Fate through Interaction with NKX2.5

    By assaying ISLET1 (ISL1) genomic occupancy in human induced pluripotent stem cell-derived cardiac progenitors or motor neuron progenitors and leveraging the deep learning approach BPNet, scientists identified motifs of other transcription factors that predicted ISL1 occupancy in each lineage.
    [Stem Cell Reports]

    Full Article

    Naringenin Improves Muscle Endurance via Activation of the Sp1-ERRγ Transcriptional Axis

    Naringenin was found to build muscle endurance in wild-type mice of different ages by increasing oxidative myofiber numbers and aerobic metabolism, and it ameliorated muscle dysfunction in mdx mice.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Loss of Adenosine A3 Receptors Accelerates Skeletal Muscle Regeneration in Mice Following Cardiotoxin-Induced Injury

    The effect of the loss of A3 receptors was investigated on the regeneration of the tibialis anterior muscle in mice following cardiotoxin-induced injury.
    [Cell Death & Disease]

    Full Article

    Empagliflozin Induces the Transcriptional Program for Nutrient Homeostasis in Skeletal Muscle in Normal Mice

    Scientists demonstrated that empagliflozin administration under ad libitum feeding did not cause weight loss but did increase transcripts of the key nutrient sensors.
    [Scientific Reports]

    Full Article

    Myosin and Tropomyosin–Troponin Complementarily Regulate Thermal Activation of Muscles

    Researchers investigated the temperature dependence of sarcomere shortening along isolated fast skeletal myofibrils using optical heating microscopy.
    [Journal of General Physiology]

    Full Article

    Wnt Signaling Regulates Ion Channel Expression to Promote Smooth Muscle and Cartilage Formation in Developing Mouse Trachea

    The authors demonstrated that trachealis muscle organization and polarity were disrupted after epithelial ablation of Wls, a cargo receptor critical for the Wnt signaling pathway, in developing trachea.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Smooth Muscle Cells-Specific Loss of OCT4 Accelerates Neointima Formation after Acute Vascular Injury

    Using an Oct4-IRES-GFP reporter mouse model, researchers found that OCT4 was reactivated in the carotid artery 18 hours post-acute ligation-induced injury, a common in vivo model of the smooth muscle cell phenotypic transitions.
    [Frontiers in Cardiovascular Medicine]

    Full Article

    Myxoid Epithelioid Smooth Muscle Tumor of the Vulva: A Distinct Entity with MEF2D::NCOA2 Gene Fusion

    Investigators presented two cases of morphologically distinct myxoid epithelioid smooth muscle tumors of the vulva with novel MEF2D::NCOA2 gene fusion.
    [Genes Chromosomes & Cancer]

    Full Article
    Enjoy your weekend. Your cells will too. Reduce medium acidosis with mTeSRâ„¢ Plus.
    REVIEWS

    Use of Human Airway Smooth Muscle In Vitro and Ex Vivo to Investigate Drugs for the Treatment of Chronic Obstructive Respiratory Disorders

    Scientists provide updated evidence on the current uses of isolated human airways in validated in vitro methods to investigate drugs in development for the treatment of chronic obstructive respiratory disorders.
    [British Journal of Pharmacology]

    Abstract

    Muscle Fiber Phenotype: A Culprit of Abnormal Metabolism and Function in Skeletal Muscle of Humans with Obesity

    The authors discuss how a lower proportion of type I fibers in the skeletal muscle of humans with obesity may explain metabolic and functional abnormalities.
    [American Journal of Physiology – Endocrinology and Metabolism]

    Abstract
    INDUSTRY AND POLICY NEWS

    NeuroTrigger Received FDA 510(k) for Its Non-Invasive Muscle Stimulation System (NTB)

    NeuroTrigger announced that its non-invasive muscle stimulation system has been granted 510(k) clearance by the US FDA for the prevention or retardation of disuse atrophy and muscle re-education to maintain or increase range of motion.
    [NeuroTrigger (PR Newswire)]

    Press Release
    FEATURED EVENT

    AACR-KCA Joint Conference on Precision Medicine in Cancer

    November 15 – 17, 2023
    Seoul, Korea

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Biological Sciences

    National University of Singapore – Singapore, Singapore

    Postdoctoral Fellow – Medicine and Genetics

    Yale University – New Haven, Connecticut, United States

    Research Assistant – Neuromuscular Diseases

    University College London – London, England, United Kingdom

    Associate Professor – Physiology

    The University of Tennessee – Memphis, Tennessee, United States

    Open Rank Faculty – Pharmacology

    University of Houston – Houston, Texas, United States

    > See All Jobs

    Submit (1)
    Brought to you by
    stemcell-logo-for newsletter-2
    Logo for the social media website X