Muscle Cell News Volume 8.36 | Nov 06 2023

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    Noshin Noorjahan
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    2023-11-06 | MUSCN 8.36


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.36 – 6 November, 2023
    TOP STORY

    Structure of the Native Myosin Filament in the Relaxed Cardiac Sarcomere

    Scientists presented the molecular architecture of native cardiac sarcomeres in the relaxed state, determined by cryo-electron tomography.
    [Nature]

    Full ArticlePress Release
    Learn how to avoid jargon and use blogs and social media channels to inform the public about your science
    PUBLICATIONSRanked by the impact factor of the journal

    Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration

    Researchers deleted a single allele of mitochondrial ribosomal protein S5 in mice and used left anterior descending coronary artery ligation surgery to induce myocardial damage in these animals.
    [Circulation]

    Abstract

    The lncRNA Sweetheart Regulates Compensatory Cardiac Hypertrophy after Myocardial Injury in Murine Males

    The authors described and characterized the cardiomyocyte specific lncRNA Sweetheart RNA, an approximately 10 kb long transcript divergently expressed from the cardiac core transcription factor coding gene Nkx2-5.
    [Nature Communications]

    Full Article

    A Human Mitofusin 2 Mutation Can Cause Mitophagic Cardiomyopathy

    Investigators determined that the rare mitofusin (MFN) 2 R400Q mutation was 15–20× over-represented in clinical cardiomyopathy, whereas this specific mutation was not reported as a cause of MFN2 mutant-induced peripheral neuropathy, Charcot–Marie–Tooth disease type 2A.
    [eLife]

    Full Article

    Regenerating Human Skeletal Muscle Forms an Emerging Niche In Vivo to Support PAX7 Cells

    Single-nucleus RNA sequencing of satellite cell-ablated mice identified the absence of a transient myofibre subtype during regeneration expressing Actc1.
    [Nature Cell Biology]

    Full ArticlePress Release

    Gli1 Marks a Sentinel Muscle Stem Cell Population for Muscle Regeneration

    Researchers found that a population of muscle stem cells, marked by Gli1 expression, was required for muscle regeneration.
    [Nature Communications]

    Full Article

    Maternal Folic Acid Supplementation Does Not Impact Skeletal Muscle Function and Metabolism in Male and Female CD-1 Mouse Offspring

    The authors determined the effect of supplemental folic acid in utero and throughout suckling on muscle size, function, and metabolism in male and female CD-1 mouse offspring.
    [Applied Physiology Nutrition And Metabolism]

    Abstract

    Survivin as a Mediator of Stiffness-Induced Cell Cycle Progression and Proliferation of Vascular Smooth Muscle Cells

    Investigators performed analyses of whole-transcriptome microarray data from mouse vascular smooth muscle cells (VSMCs) cultured on stiff hydrogels simulating arterial pathology that identified 623 genes that were significantly and differentially expressed relative to expression in VSMCs cultured on soft hydrogels.
    [APL Bioengineering]

    Full Article

    NAMPT Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation by TLR4/NF-κB/PLK4 Signaling Pathway

    Primary cultured pulmonary artery smooth muscle cells were attained from male Sprague-Dawley rats. Western blotting, RT-PCR, ELISA, cell transfection, cell counting kit-8, and EdU incorporation assays were used in the experiments.
    [European Journal of Pharmacology]

    Abstract

    Apelin Is Expressed in Intimal Smooth Muscle Cells and Promotes Their Phenotypic Transition

    Researchers investigated the role of apelin in the conversion of smooth muscle cells switching from a contractile/differentiated to a synthetic/dedifferentiated phenotype, as well as its relationship with S100A.
    [Scientific Reports]

    Full Article
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    REVIEWS

    From Workout to Molecular Switches: How Does Skeletal Muscle Produce, Sense, and Transduce Subcellular Redox Signals?

    The authors delve into the current research on subcellular redox biochemistry and its role in the physiological adaptations to exercise.
    [Free Radical Biology and Medicine]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    ResoTher Pharma Receives a €2.5 Million Grant from European Innovation Council (EIC) to Support a Phase IIa Clinical Study of Their Lead Candidate RTP-026 for Myocardial Infarction

    ResoTher Pharma announced that the company has received a €2.5 million grant from the EIC to support the development of the company’s Lead Compound, RTP-026, in a Phase IIa clinical study in myocardial infarction.
    [ResoTher Pharma (PR Newswire)]

    Press Release
    FEATURED EVENT

    Single Cell View 3D Genome Architecture

    November 26 – 29, 2023
    Buxted Park, England, United Kingdom

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    JOB OPPORTUNITIES

    Staff Associate – Cardiomyocytes

    Columbia University – New York City, New York, United States

    Research Fellow – Biological Sciences

    National University of Singapore – Singapore, Singapore

    Postdoctoral Fellow – Medicine and Genetics

    Yale University – New Haven, Connecticut, United States

    Associate Professor – Physiology

    The University of Tennessee – Memphis, Tennessee, United States

    Open Rank Faculty – Pharmacology

    University of Houston – Houston, Texas, United States

    > See All Jobs

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