 | | Vol. 8.38 – 27 November, 2023 |
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| The authors identified N-n-butyl haloperidol iodide (F2)-mediated nuclear accumulation of forkhead box O1 (FoxO1) is dependent on AMP-activated protein kinase (AMPK), as blockage of AMPK with compound C induced nuclear exit of FoxO1.
[Journal Of Cellular And Molecular Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The ability of transient receptor potential vanilloid 4 (TRPV4) to modulate the endoplasmic reticulum stress and apoptosis was assessed in vitro through the administration of the TRPV4 antagonist HC-067047 or the agonist GSK1016790A.
[Cellular Signalling] |
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| Original data of sepsis induced cardiotoxicity was derived from Gene Expression Omnibus dataset. Functional enrichment analysis was used to analysis sepsis induced cardiotoxicity related signaling pathways.
[Biochemical and Biophysical Research Communications] |
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| | Investigators demonstrated that iron deficiency-mediated ferritinophagy impeded myogenic differentiation. Mechanistically, ferritinophagy induced RNF20 degradation through the autophagy-lysosomal pathway.
[Science Advances] |
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| Adeno-associated virus-mediated skeletal muscle miR-92b overexpression in C57BLKS/J mice, and global knockout of miR-92b mice were used to explore the function of miR-92b in glycogen and lactate metabolism in skeletal muscle.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| Researchers showed that mitochondrial Ca2+ uniporter (MCU) b, an inhibitor of MCU-mediated Ca2+ influx, was induced by caloric restriction, where it increased mitochondrial fatty acid utilization.
[Cell Reports] |
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| Scientists evaluated the effects of electrical stimulation of the diaphragm muscle on genetic changes during 12 hours of mechanical ventilation.
[Scientific Reports] |
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| The authors found that the loss of BACH1 in human embryonic stem cells (hESCs) attenuated the expression of vascular smooth muscle cell (VSMC) marker genes, whereas overexpression of BACH1 after mesoderm induction increased the expression of VSMC markers during in vitro hESC-VSMC differentiation.
[Cell Reports] |
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| Bioinformatic analyses and experimental validation were performed to reveal ferroptosis and heme oxygenase 1 (HO-1) expression in acute Stanford type A aortic dissection.
[Heliyon] |
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| Scientists evaluate how the nine classic hallmarks of aging including genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication contribute to skeletal muscle aging and the pathophysiology of sarcopenia.
[Clinical Science] |
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| The Marfan Foundation awarded five new two-year research grants including two Innovator Awards and three Victor McKusick Fellowship Awards. The research projects focus on aortic dissection and thoracic aortic aneurysms.
[The Marfan Foundation] |
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| December 4 – 7, 2023
Dublin, Ireland |
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| | Florida State University – Tallahassee, Florida, United States |
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| | Institute of Genetic and Biomedical Research – Milan, Italy |
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| | Heidelberg University – Heidelberg, Germany |
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| | Columbia University – New York City, New York, United States |
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| | Yale University – New Haven, Connecticut, United States |
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