Muscle Cell News Volume 8.40 | Dec 11 2023

December 11, 2023

2023-12-11 | MUSCN 8.40

Muscle Cell News by STEMCELL Technologies

Vol. 8.40 – 11 December, 2023

TOP STORY

The YAP1/TAZ-TEAD Transcriptional Network Regulates Gene Expression at Neuromuscular Junctions in Skeletal Muscle Fibers

The authors examined Yes-associated protein (YAP) 1/transcriptional co-activator with PDZ-binding motif (TAZ)-TEA-domain transcription factor (TEAD) signaling pathway activity at neuromuscular junctions of skeletal muscle fibers in adult mice.
[Nucleic Acids Research]

Full Article
Graphical Abstract

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PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Plakophilin 2 Gene Therapy Prevents and Rescues Arrhythmogenic Right Ventricular Cardiomyopathy in a Mouse Model Harboring Patient Genetics

Investigators generated a mouse model harboring a plakophilin 2 mutation affecting RNA splicing, recapitulating arrhythmogenic right ventricular cardiomyopathy features and sudden death starting at four weeks.
[Nature Cardiovascular Research]

Full Article

Cannabidiol Represses miR-143 to Promote Cardiomyocyte Proliferation and Heart Regeneration after Myocardial Infarction

Researchers investigated the pharmacological effects of cannabidiol on heart regeneration in post-myocardial infarction mice.
[European Journal of Pharmacology]

Abstract Graphical Abstract

Changes in Glutamic Oxaloacetic Transaminase 2 during Rat Physiological and Pathological Cardiomyocyte Hypertrophy

RNA-seq analysis and colorimetric methods were used to evaluate the changes in glutamic oxaloacetic transaminase mRNA and activity, respectively.
[BMC Cardiovascular Disorders]

Full Article

SKELETAL MUSCLE CELLS

Class IIa HDACs Inhibit Cell Death Pathways and Protect Muscle Integrity in Response to Lipotoxicity

Researchers showed that lipotoxicity increased histone deacetylase (HDAC) 4 and 5, which reduced the expression of metabolic genes and oxidative metabolism in skeletal muscle, resulting in increased non-oxidative glucose metabolism.
[Cell Death & Disease]

Full Article

Filamin a Cooperates with the Androgen Receptor in Preventing Skeletal Muscle Senescence

Scientists reported that expression of the androgen receptor in skeletal muscle biopsies from 20 subjects was higher in young, as compared with old subjects.
[Cell Death Discovery]

Full Article

Downregulation of Mitochondrial Metabolism Is a Driver for Fast Skeletal Muscle Loss during Mouse Aging

Investigators recurred to gene expression and metabolite profiling in a glycolytic muscle, Extensor digitorum longus, from young and aged C57BL/6JRj mice.
[Communications Biology]

Full Article

SMOOTH MUSCLE CELLS

S-Adenosylmethionine Attenuates Angiotensin II-Induced Aortic Dissection Formation by Inhibiting Vascular Smooth Muscle Cell Phenotypic Switch and Autophagy

The authors constructed an animal model of Alzheimer’s disease (AD) using subcutaneous minipump continuous infusion of AngII-induced ApoE^-/-mice and a cytopathic model using AngII-induced primary vascular smooth muscle cells to investigate the possible role of S-adenosylmethionine in AD.
[Biochemical Pharmacology]

Full Article

PANoptosis in Vascular Smooth Muscle Cells Regulated by TNF-α/IL-1β Can Be a New Target for Alleviating the Progression of Abdominal Aortic Aneurysm

Researchers investigated the role of PANoptosis on the occurrence and development of abdominal aortic aneurysm.
[Physiological Genomics]

Abstract

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REVIEWS

A Critical Discussion on the Relationship between E3 Ubiquitin Ligases, Protein Degradation, and Skeletal Muscle Wasting: It’s Not That Simple

The authors examine the usefulness of monitoring E3 ubiquitin ligases for determining specific or bulk protein degradation rates in the settings of skeletal muscle atrophy.
[American Journal Of Physiology-Cell Physiology]

Abstract Graphical Abstract

INDUSTRY AND POLICY NEWS

Surge in Number of ‘Extremely Productive’ Authors Concerns Scientists

Some researchers publish a new paper every five days, on average. Data trackers suspect not all their manuscripts were produced through honest labor.
[Nature]

Press Release

FEATURED EVENT

Muscle Cell News Volume 8.40 | Dec 11 2023

The YAP1/TAZ-TEAD Transcriptional Network Regulates Gene Expression at Neuromuscular Junctions in Skeletal Muscle Fibers

Plakophilin 2 Gene Therapy Prevents and Rescues Arrhythmogenic Right Ventricular Cardiomyopathy in a Mouse Model Harboring Patient Genetics

Cannabidiol Represses miR-143 to Promote Cardiomyocyte Proliferation and Heart Regeneration after Myocardial Infarction

Changes in Glutamic Oxaloacetic Transaminase 2 during Rat Physiological and Pathological Cardiomyocyte Hypertrophy

Class IIa HDACs Inhibit Cell Death Pathways and Protect Muscle Integrity in Response to Lipotoxicity

Filamin a Cooperates with the Androgen Receptor in Preventing Skeletal Muscle Senescence

Downregulation of Mitochondrial Metabolism Is a Driver for Fast Skeletal Muscle Loss during Mouse Aging

S-Adenosylmethionine Attenuates Angiotensin II-Induced Aortic Dissection Formation by Inhibiting Vascular Smooth Muscle Cell Phenotypic Switch and Autophagy

PANoptosis in Vascular Smooth Muscle Cells Regulated by TNF-α/IL-1β Can Be a New Target for Alleviating the Progression of Abdominal Aortic Aneurysm

A Critical Discussion on the Relationship between E3 Ubiquitin Ligases, Protein Degradation, and Skeletal Muscle Wasting: It’s Not That Simple

Surge in Number of ‘Extremely Productive’ Authors Concerns Scientists

Stem Cells and Regeneration

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Postdoctoral Associate – Cardiac Regeneration

Postdoctoral Position – Inflammation/Regeneration

Graduate Research Assistant – Exercise Physiology/Nutrition

Postdoctoral Position – Cardiac and Skeletal Muscle Research

PhD Position: Multi-Omics Data Study

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