 | | Vol. 9.01 – 15 January, 2024 |
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| Cardiac-specific conditional knockout of specificity protein 1 (Sp1) mice were constructed to investigate the role of SP1 in the heart.
[Circulation Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| CXXC zinc finger protein 1 (Cfp1), a key epigenetic factor in multi-lineage cell development, was underexplored in its influence on cardiomyocyte maturation. Reearchers investigated the role and mechanisms of Cfp1 in this context.
[Advanced Science] |
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| Scientists showed that perlecan expression increased as cardiomyocytes mature in vivo and during human pluripotent stem cell differentiation to cardiomyocytes.
[Cell Reports] |
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| The authors demonstrated that deficiency of a deubiquitinase, Josephin domain-containing protein 2 (JOSD2), ameliorated isoprenaline- and myocardial infarction-induced cardiac hypertrophy, fibrosis, and dysfunction both in vitro and in vivo.
[Cellular And Molecular Life Sciences] |
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| | Researchers provided comprehensive insight into the RNA profile and chromatin accessibility of different myofibers, combining RNA sequencing with an assay for transposase-accessible chromatin with high-throughput sequencing.
[Cellular & Molecular Biology Letters] |
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| Investigators used ribosome-related gene expression as a proxy measure for ribosome content and hypothesised that aerobic conditioning and resistance training would increase ribosome-related gene expression.
[Journal Of Cellular Physiology] |
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| Using hydrogels of tuneable stiffness and lysyl oxidase-mediated stiffening of human saphenous vein ex vivo, researchers investigated the role of substrate stiffness in the regulation of vascular smooth muscle cells calcification.
[Journal Of Molecular And Cellular Cardiology] |
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| Exposure to cholesterol in vascular smooth muscle cells activated inflammatory signaling and induced senescence, while reducing HRD1 protein expression.
[Journal of Molecular and Cellular Cardiology] |
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| As age advances, senescent cells accumulate in our body organs comprising the cardiovascular system. Notably, these cells stimulate pro-survival pathways and hinder their regenerative capacity.
[European Heart Journal] |
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| The authors review factors that drive the initiation and progression of this vasculopathy in vascular smooth muscle cells.
[Hypertension] |
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| Published in the journal Nature Communications, a study involved 25 patients with long COVID who reported experiencing malaise after exercising, and 21 people who had had COVID but made a full recovery.
[The Guardian] |
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| The University of Victoria (UVic) celebrates the achievements of their exceptional researchers whose dedication shapes academia and societal progress, including Nicole York, who is studying the role of the ankyrin-B proteins in cardiomyocyte development.
[University of Victoria] |
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| February 27 – 28, 2024
London, England, United Kingdom |
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| | Sorbonne University – Paris, France |
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| | University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | Michigan State University – East Lansing, Michigan, United States |
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Postdoctoral Associate – Cardiac Regeneration | | Baylor College of Medicine – Houston, Texas, United States |
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