 | | Vol. 9.02 – 22 January, 2024 |
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| Investigators leveraged an in vivo mosaic knockout system to characterize the role of Carm1, the founding member of protein arginine methyltransferase, in cardiomyocyte maturation.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that adipose tissue released amyloid beta 42 (Aβ42), which was increased from adipose tissue of male mice with obesity and is associated with higher plasma Aβ42.
[Nature Communications] |
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| Through CD36, fatty acids functioned as both fuels and growth signals to promote muscle stem cell (MuSCs) proliferation. Mechanistically, injury triggered the translocation of CD36 in MuSCs, which relied on dynamic palmitoylation of STX11.
[Developmental Cell] |
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| Investigators developed a multi-lineage, fully-integrated, cardiovascular organ chip that could enhance human induced pluripotent stem cell (hiPSC)-endothelial cell and hiPSC-cardiomyocyte functional and genetic maturity, model endothelial barrier permeability, and demonstrate long-term functional stability.
[Lab On A Chip] |
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| The authors showed that heterochromatin markers, including histone H3K9 di/tri-methylation and HP1, decreased with age in muscle stem cells as a consequence of the depletion of the methyl donor S-adenosylmethionine.
[Nature Metabolism] |
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| Researchers used hiPSC-cardiomyocytes from Duchenne muscular dystrophy (DMD) patients selected by Speckle-tracking echocardiography and canine DMD cardiac biopsies to assess key early-stage Duchenne dilated cardiomyopathy features.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| Scientists developed a procedure including RNA library preparation and a simple pipeline calculating alternative polyadenylation (APA)-shift ratio as a readout for PABPN1 activity. Comparing APA-shift resulted to previously published PAS utilization and APA-shift results, investigators validated this procedure.
[HGG Advances] |
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| Investigators combined live-cell imaging and machine learning to monitor ERK1/2-inhibited primary murine skeletal muscle precursor cells, that transitioned rapidly and robustly from proliferating myoblasts to post-mitotic myocytes and then fused, forming multinucleated myotubes.
[Molecular Systems Biology] |
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| The morphological changes and association between serping1 and α-syn were investigated in the colon of the 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced chronic Parkinson’s disease model.
[Scientific Reports] |
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| Scientists summarize the research progress on the mechanisms and challenges of mesenchymal stromal cells and induced pluripotent stem cell-derived cardiomyocytes in post-myocardial infarction heart repair.
[Journal of Molecular and Cellular Cardiology] |
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| The US Environmental Protection Agency (EPA) has abandoned a controversial plan to phase out all use of mammals to test the safety of chemicals by 2035.
[Science Insider] |
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| February 21 – 24, 2024
San Antonio, Texas, United States |
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| | Sorbonne University – Paris, France |
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| | National University of Singapore – Singapore, Singapore |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Institut Pasteur – Paris, France |
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| | Florida State University – Tallahassee, Florida, United States |
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