 | | Vol. 9.03 – 29 January, 2024 |
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| Researchers developed a protein patterning process within multiwell plates to engineer patterned induced pluripotent stem cell–derived atrial cardiomyocyte and atrial fibroblast coculture.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Contractility was measured of human induced pluripotent stem cell-derived cardiomyocytes harboring a hypertrophic cardiomyopathy mutation cultured in 2D and in 3D engineered heart tissue.
[Cardiovascular Research] |
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| In vivo, 2% α-ketoglutarate was added to the drinking water of mice undergoing transverse aortic constriction surgery.
[Molecular Medicine] |
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| Following culture under simulated microgravity in a random positioning machine for seven days, 3D human induced pluripotent stem cell-cardiomyocytes had increased mitochondrial content as detected by a mitochondrial protein and mitochondrial DNA to nuclear DNA ratio.
[Scientific Reports] |
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| Investigators showed that the Q reductase electron-transfer flavoprotein dehydrogenase (ETFDH) was essential for oxidative phosphorylation complex III activity in skeletal muscle.
[Nature Metabolism] |
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| Researchers analyzed the role of mitoKATP in determining skeletal muscle structure and activity. The pore-forming subunits of mitoKATP muscles were characterized by mitochondrial cristae remodeling and defective oxidative metabolism.
[Cell Death & Disease] |
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| Scientists showed that lowering apolipoprotein B-containing lipoproteins reduced nuclear factor kappa-light-chain-enhancer of activated B cells signaling in SMC-derived fibromyocytes and chondromyocytes.
[Nature Cardiovascular Research] |
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| | Using single-cell RNAseq and hypoxia-induced pulmonary hypertension models, researchers showed that hypoxia-inducible factor 2α (HIF2α) was a major molecular regulator for the transformation of pericytes into smooth muscle cell-like cells.
[EMBO reports] |
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| The authors reported the use of whole fresh human and pig airways to perform a detailed side-by-side qualitative and quantitative validation of polarization-sensitive optical coherence tomography against gold standard histology.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Investigators identified aortic macrophage as the main expressing cell of gasdermin D (GSDMD) in aortic aneurysm.
[International Immunopharmacology] |
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| The authors review fundamental studies on muscular pain, encompassing the characteristics of primary afferent fibers and neurons, spinal and thalamic projections, several muscular pain models, and possible neurochemical mechanisms of muscle pain.
[Journal Of Physiological Sciences] |
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| The Mechanobiology Institute at the National University of Singapore (NUS) has secured S$49 million in funding from the National Research Foundation to promote research aimed at advancing the field of mechanobiology by developing novel technologies and therapeutic targets for age-related ailments.
[NUS Mechanobiology Institute] |
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| March 11 – 13, 2024
Lisbon, Portugal |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Brown University – Providence, Rhode Island, United States |
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| | University of Texas at Tyler – Tyler, Alabama, United States |
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| | Sorbonne University – Paris, France |
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| | Baylor College of Medicine – Houston, Texas, United States |
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