 | | Vol. 9.04 – 5 February, 2024 |
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| Scientists investigated the effects of statins on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-derived CMs). hiPSC-derived CMs were exposed to simvastatin, atorvastatin, rosuvastatin, and cerivastatin at increasing concentrations.
[Basic Research in Cardiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the effects of fludioxonil on mitochondria in AC16 human cardiomyocytes and H9c2 rat cardiomyoblasts.
[Environmental Toxicology] |
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| Designated adenoviral preprotrypsin-leading sequence apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was used to overexpress secretory APE1/Ref-1 and assess its role in preventing doxorubicin-induced cardiomyopathy in vitro.
[ESC Heart Failure] |
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| Scientists showed that depletion of the histone variant H2A.Z in mouse skeletal muscle caused oxidative stress, oxidation of proteins, accumulation of DNA damages, and both neuromuscular junction and mitochondria lesions that consequently led to premature muscle aging and reduced life span.
[Nucleic Acids Research] |
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| Investigators quantified the expression of pro-BDNF and mBDNF in human skeletal muscle and plasma at rest, after acute exercise, and after fasting. Pro-BDNF and mBDNF were analyzed with immunoblotting, ELISA, immunohistochemistry, and qPCR.
[Function] |
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| C57BL/6J mice were randomly assigned to normal control and high-fat-diet groups, and the mice that developed diet-induced diabetes were assigned to diabetes control, and intervention groups with one hour or four weeks exposure to a hypoxic environment, exercise in normoxia, and exercise in hypoxia.
[PLOS One] |
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| Investigators showed that the internal anal sphincter contained multiple pacemakers. These pacemakers spontaneously generated propagating calcium waves that drove rhythmic contractions and established the basal tone.
[Communications Biology] |
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| To investigate the potential involvement of damage-associated molecular patterns in vascular calcification, scientists assessed the impact of externally added histones on calcium and inorganic phosphate-induced calcification in mouse vascular smooth muscle cells.
[Journal Of Biochemistry] |
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| The authors investigated the efficacy of zinc finger X-chromosomal protein in mouse pulmonary artery smooth muscle cells (PASMCs) proliferation during pulmonary arterial hypertension. PASMCs were cultured in hypoxic conditions.
[Cardiovascular Toxicology] |
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| Scientists summarize the reported observations and discuss potential mechanisms of RNA-binding motif protein 20 (RBM20) cardiomyopathy derived from studies employing in vivo animal models and in vitro human-induced pluripotent stem cell–derived cardiomyocytes.
[Circulation-Genomic And Precision Medicine] |
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| The authors highlight the heterogeneity, molecular markers, and functional properties of interstitial progenitor cells, and explore the role of muscle stem/progenitor cells in skeletal muscle homeostasis, aging, and muscle-related diseases.
[Cellular And Molecular Life Sciences] |
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| Kevin Murach, an assistant professor in the College of Education and Health Professions Department of Health, Human Performance and Recreation, has been awarded the 2024 Cell & Molecular Physiology Section New Investigator Award from the American Physiological Society.
[University of Arkansas] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | The Jackson Lab – Farmington, Connecticut. United States |
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| | Brown University – Providence, Rhode Island, United States |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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