Muscle Cell News Volume 9.05 | Feb 12 2024

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    Noshin Noorjahan
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    2024-02-12 | MUSCN 9.05


    Muscle Cell News by STEMCELL Technologies
    Vol. 9.05 – 12 February, 2024
    TOP STORY

    Ketone Flux through BDH1 Supports Metabolic Remodeling of Skeletal and Cardiac Muscles in Response to Intermittent Time-Restricted Feeding

    Using mice with beta-hydroxybutyrate dehydrogenase 1 (BDH1) deficiency in striated muscles, investigators discovered that this enzyme optimized fatty acid oxidation efficiency and exercised tolerance during acute fasting.
    [Cell Metabolism]

    Full ArticleGraphical Abstract
    Explore virtual support and resources to stay productive and connected with your field.
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    Myoglobin Modulates the Hippo Pathway to Promote Cardiomyocyte Differentiation

    Researchers showed that deletion of myoglobin in cardiomyocyte models decreased the gene expression of differentiation markers and stimulated cellular proliferation, consistent with cardiomyocyte de-differentiation.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Characterizing Ionic Currents of Atrial-Like and Ventricular-Like hiPSC-Cardiomyocytes

    Scientists conducted an electrophysiological characterization of ionic currents, electrical activity, and contractility in cardiomyocytes derived from human induced pluripotent stem cells.
    [Biophysical Journal]

    Abstract

    Opening of the Mitochondrial Permeability Transition Pore as a Key Component in the Mitochondrial-Junctional Sarcoplasmic Reticulum Interface in Cardiomyocytes

    The authors analyzed the mitochondrial permeability transition pore proposed candidates by protein distribution and co-immunoprecipitation assay in different fractions of the heart.
    [Biophysical Journal]

    Abstract

    Influence of Skeletal Muscle and Intermuscular Fat on Postoperative Complications and Long-Term Survival in Rectal Cancer Patients

    This retrospective cohort study included patients with rectal cancer who underwent surgical resection. CT images within 3 months prior to the surgery were used to quantify the indices of skeletal muscle and adipose tissue at the levels of the third lumbar vertebra and umbilicus.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article

    Chronic Hypoxia Impairs Skeletal Muscle Repair via HIF-2α Stabilization

    Experimental mice were exposed to prolonged normobaric hypoxic air to establish a chronic hypoxia model. The impact of chronic hypoxia on body composition, muscle mass, muscle strength, and the expression levels of hypoxia-inducible factors HIF-1α and HIF-2α in muscle stem cell was examined.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article

    Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations

    Using human aortic smooth muscle cells from 123 multiancestry healthy heart transplant donors, scientists collected the serum-free media in which the cells were cultured for 24 hours and conducted liquid chromatography–tandem mass spectrometry-based proteomic analysis of the conditioned media.
    [Arteriosclerosis Thrombosis And Vascular Biology]

    Abstract

    Terazosin Attenuates Abdominal Aortic Aneurysm Formation by Downregulating Peg3 Expression to Inhibit Vascular Smooth Muscle Cell Apoptosis and Senescence

    The authors investigated the effects of terazosin in two abdominal aortic aneurysm animal models: angiotensin II infusion in Apoe−/− mice and calcium chloride application in C57BL/6J mice.
    [European Journal of Pharmacology]

    Full Article

    Mitochondrial BK Channels in Senescent Vascular Smooth Muscle Cells

    Scientists induced senescence of human aorta-derived smoth muscle cells (SMCs) by H2O2. Then they described changes in mitochondrial network and expression level of the selected genes encoding proteins connected to mitochondrial function in senescent and control SMCs.
    [Biophysical Journal]

    Abstract

    Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic Dissection

    Alterations of histopathology and inflammatory factor levels in β-aminopropionitrile-induced aortic dissection mouse model were evaluated through Hematoxylin–Eosin staining and ELISA.
    [Cardiovascular Toxicology]

    Abstract
    hPSC-derived cardiomycyte generated by STEMdiffâ„¢ Cardiomyocyte Differentiation Kit
    REVIEWS

    The Structure and Function of Lamin A/C: Special Focus on Cardiomyopathy and Therapeutic Interventions

    Scientists focus on the structural organization, expression pattern, and function of lamin A/C, its interacting partners, and the pathophysiology associated with mutations in the lamin A/C gene, with special emphasis on cardiovascular diseases.
    [Life Sciences]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    China Conducts First Nationwide Review of Retractions and Research Misconduct

    Universities must declare all their retractions and launch investigations into misconduct cases; a Nature analysis reveals that since 2021 there have been more than 17,000 Chinese co-authored retractions.
    [Nature News]

    Editorial
    FEATURED EVENT

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    March 24 – 29, 2024
    Galveston, Texas, United States

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Cardiology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowships – Cardiac Cell and Tissue Engineering

    Harvard University – Cambridge, Massachusetts, United States

    Research Fellow – Biological Sciences

    National University of Singapore – Singapore, Singapore

    Postdoctoral Research Fellow – Heart/Lung/Vascular Biology

    Cincinnati Children’s Hospital – Cincinnati, Ohio, United States

    Postdoctoral Associate – Cell & Molecular Biology

    The Jackson Lab – Farmington, Connecticut, United States

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