Muscle Cell News Volume 9.06 | Feb 26 2024

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    2024-02-26 | MUSCN 9.06


    Muscle Cell News by STEMCELL Technologies
    Vol. 9.06 – 26 February, 2024
    TOP STORY

    Homologous Mutations in Human β, Embryonic, and Perinatal Muscle Myosins Have Divergent Effects on Molecular Power Generation

    Researchers investigated the effects of the homologous mutations on key factors of molecular power production using recombinantly expressed human β, embryonic, and perinatal myosin subfragment-1.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Age-Related Changes in Human Skeletal Muscle Transcriptome and Proteome Are More Affected by Chronic Inflammation and Physical Inactivity than Primary Aging

    Investigators demonstrated for the first time the distinct role of primary aging and chronic inflammation/physical inactivity – the most important drivers of secondary aging, in the regulation of transcriptomic and proteomic profiles in human skeletal muscle.
    [Aging Cell]

    Full Article

    Neurofibromin 1 Controls Metabolic Balance and Notch-Dependent Quiescence of Murine Juvenile Myogenic Progenitors

    Scientists showed that, in mice, neurofibromin 1 (Nf1) was not required in muscle fibers, but specifically in early postnatal myogenic progenitors, where Nf1 loss led to cell cycle exit and differentiation blockade.
    [Nature Communications]

    Full Article

    Synchronous Force and Ca2+ Measurements for Repeated Characterization of Excitation-Contraction Coupling in Human Myocardium

    The authors presented a method for synchronized acquisition of intracellular Ca2+ and contraction force in long-term cultivated slices of human failing myocardium.
    [Communications Biology]

    Full Article

    Novel Muscle-Derived Extracellular Matrix Hydrogel Promotes Angiogenesis and Neurogenesis in Volumetric Muscle Loss

    Scientists reported the generation and characterization of hydrogels derived from decellularized extracellular matrix prepared from WT or thrombospondin (TSP)-2 null muscle tissue.
    [Matrix Biology]

    Full Article

    Nupr1-Mediated Vascular Smooth Muscle Cell Phenotype Transformation Involved in Methamphetamine Induces Pulmonary Hypertension

    Mice were made to induce pulmonary hypertension upon chronic intermittent treatment with methamphetamine. Their right ventricular systolic pressure was measured to assess pulmonary artery pressure.
    [Cell Biology And Toxicology]

    Full ArticleGraphical Abstract

    Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification

    Serum was collected from patients with chronic kidney disease and controls, and the levels of 4-hydroxynonenal and 8-iso-prostaglandin F2α were measured.
    [AAPS Pharmscitech]

    Abstract
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    REVIEWS

    Non-Genomic Actions of Steroid Hormones on the Contractility of Non-Vascular Smooth Muscles

    The classical pathway of steroid actions is mediated by nuclear receptors, which regulate genes to modify biological processes. Non-genomic pathways of steroid actions are also known, mediated by cell membrane-located seven transmembrane domain receptors.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Parent Project Muscular Dystrophy Announces Pediatric Certified Duchenne Care Center, Penn State Health Children’s Hospital

    Parent Project Muscular Dystrophy announced the expansion of their Certified Duchenne Care Center Program with the certification of the clinic at Penn State Health Children’s Hospital in Hershey, Pennsylvania.
    [Parent Project Muscular Dystrophy]

    Press Release
    FEATURED EVENT

    2024 Cincinnati International Symposium

    April 4 – 5, 2024
    Cincinnati, Ohio, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Metabolic Research

    City of Hope – Duarte, California, United States

    Postdoctoral Research Associate – Neuro-Oncology

    University of Southern California – Los Angeles, California, United States

    Postdoc Fellows and Research Scientist – Cardiac / Renal Biology

    Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Postdoctoral Associate – Cardiology

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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