| Vol. 9.11 – 1 April, 2024 |
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| Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| RNA-sequencing analysis revealed an increased HtrA serine peptidase 1 (HTRA1) expression in patients with dilated cardiomyopathy which was strongly correlated with myocardial fibrosis. [Journal of Translational Medicine] |
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| Researchers determined the role of histidine triad nucleotide-binding protein 2 (HINT2) in cardiac remodeling. HINT2 expression levels were found to be lower in failing hearts and hypertrophy cardiomyocytes. [Journal of Cellular and Molecular Medicine] |
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| Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro. [Stem Cell Reports] |
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| Investigators performed RNA-Seq analysis coupled with review by QIAGEN Ingenuity Pathway Analysis software on human aortic smooth muscle cells cultured for three days in microgravity and aboard the International Space Station to assess the transcriptomic changes that occured during spaceflight. [npj Microgravity] |
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| The authors investigated the role of integrin α5β1 and FAK in patients with acute type A aortic dissection and the potential underlying mechanisms. [BMC Cardiovascular Disorders] |
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| Scientists comprehensively examine the mechanobiology of A-type lamins, the role of mechanosensitive signaling pathways, and their intricate interplay in the pathogenesis of cardiolaminopathy. [Cell Communication and Signaling] |
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| Dr. Wong received a Research Excellence, Diversity, and Independence early career transition award from the Canadian Institutes of Health Research to study ways to improve health services and health equity for older patients who have medical issues related to bones, joints, muscles, and connective tissue. [Ontario Tech University] |
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| April 24 – 26, 2024 Vienna, Austria |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Sapienza University – Rome, Italy |
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| Brown University – Providence, Rhode Island, United States |
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| French National Institute for Health Research (INSERM) – Nantes, France |
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| Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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