Muscle Cell News Volume 9.11 | Apr 1 2024

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    2024-04-01 | MUSCN 9.11


    Muscle Cell News by STEMCELL Technologies
    Vol. 9.11 – 1 April, 2024
    TOP STORY

    Myosin-Binding Protein C Regulates the Sarcomere Lattice and Stabilizes the OFF States of Myosin Heads

    Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle.
    [Nature Communications]

    Full Article
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    HTRA1-Driven Detachment of Type I Collagen from Endoplasmic Reticulum Contributes to Myocardial Fibrosis in Dilated Cardiomyopathy

    RNA-sequencing analysis revealed an increased HtrA serine peptidase 1 (HTRA1) expression in patients with dilated cardiomyopathy which was strongly correlated with myocardial fibrosis.
    [Journal of Translational Medicine]

    Full Article

    HINT2 Protects against Pressure Overload-Induced Cardiac Remodeling through Mitochondrial Pathways

    Researchers determined the role of histidine triad nucleotide-binding protein 2 (HINT2) in cardiac remodeling. HINT2 expression levels were found to be lower in failing hearts and hypertrophy cardiomyocytes.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    MST1/2 Regulates Fibro/Adipogenic Progenitor Fate Decisions in Skeletal Muscle Regeneration

    Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro.
    [Stem Cell Reports]

    Full Article

    Spaceflight Effects on Human Vascular Smooth Muscle Cell Phenotype and Function

    Investigators performed RNA-Seq analysis coupled with review by QIAGEN Ingenuity Pathway Analysis software on human aortic smooth muscle cells cultured for three days in microgravity and aboard the International Space Station to assess the transcriptomic changes that occured during spaceflight.
    [npj Microgravity]

    Full Article

    A Decrease in Integrin α5β1/FAK Is Associated with Increased Apoptosis of Aortic Smooth Muscle Cells in Acute Type A Aortic Dissection

    The authors investigated the role of integrin α5β1 and FAK in patients with acute type A aortic dissection and the potential underlying mechanisms.
    [BMC Cardiovascular Disorders]

    Full Article
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    REVIEWS

    From Gene to Mechanics: A Comprehensive Insight into the Mechanobiology of LMNA Mutations in Cardiomyopathy

    Scientists comprehensively examine the mechanobiology of A-type lamins, the role of mechanosensitive signaling pathways, and their intricate interplay in the pathogenesis of cardiolaminopathy.
    [Cell Communication and Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Ontario Tech Post-Doctoral Research Fellow Receives New Federal Funding to Help Older Canadians Fight Back Pain and Arthritis

    Dr. Wong received a Research Excellence, Diversity, and Independence early career transition award from the Canadian Institutes of Health Research to study ways to improve health services and health equity for older patients who have medical issues related to bones, joints, muscles, and connective tissue.
    [Ontario Tech University]

    Press Release
    FEATURED EVENT

    Microsymposium on RNA Biology

    April 24 – 26, 2024
    Vienna, Austria

    > See All Events

    JOB OPPORTUNITIES

    Senior Researcher – Cardiovascular and Endothelial Biology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Positions – Biotechnology

    Sapienza University – Rome, Italy

    Postdoctoral Research Associate – Molecular Biology, Cell Biology, & Biochemistry

    Brown University – Providence, Rhode Island, United States

    Postdoctoral Position – Cardiac Physiology

    French National Institute for Health Research (INSERM) – Nantes, France

    Postdoc Fellows and Research Scientist – Cardiac / Renal Biology

    Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States

    > See All Jobs

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