Muscle Cell News Volume 9.12 | Apr 08 2024

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    Jamie Kang
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    2024-04-08 | MUSCN 9.12


    Muscle Cell News by STEMCELL Technologies
    Vol. 9.12 – 8 April, 2024
    TOP STORY

    NFĸB Signaling Drives Myocardial Injury via CCR2+ Macrophages in a Preclinical Model of Arrhythmogenic Cardiomyopathy

    Researchers found that nuclear factor kappa-B (NFκB) signaling in cardiac myocytes drove myocardial injury, contractile dysfunction, and arrhythmias in Dsg2mut/mut mice. NFκB signaling in cardiac myocytes mobilized macrophages expressing C-C motif chemokine receptor-2 (CCR2+ cells) to affected areas.
    [Journal Of Clinical Investigation]

    Abstract
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    Mitolnc Controls Cardiac BCAA Metabolism and Heart Hypertrophy by Allosteric Activation of BCKDH

    Investigators described the function of mitolnc in cardiomyocytes, a nuclear encoded long non-coding RNA, located in mitochondria and directly interacting with the branched-chain ketoacid dehydrogenase (BCKDH) complex to increase its activity.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract

    Three-Dimensional Imaging Studies in Mice Identify Cellular Dynamics of Skeletal Muscle Regeneration

    Researchers found that myofibers form via two distinct phases of fusion and the residual basement membrane of necrotic myofibers was critical for promoting fusion and orienting regenerated myofibers.
    [Developmental Cell]

    AbstractGraphical Abstract

    TP53INP2-Dependent Activation of Muscle Autophagy Ameliorates Sarcopenia and Promotes Healthy Aging

    Scientists showed that the autophagy regulator TP53INP2/TRP53INP2 was decreased during aging in mouse and human skeletal muscle.
    [Autophagy]

    Full Article

    Impact of Capillary and Sarcolemmal Proximity on Mitochondrial Structure and Energetic Function in Skeletal Muscle

    To evaluate the impact of capillary versus sarcolemmal proximity, researchers compared the structure and function of skeletal muscle mitochondria located either lateral to embedded capillaries (PVM), adjacent to the sarcolemma but not in PVM pools or interspersed between sarcomeres.
    [The Journal of Physiology]

    Full ArticleGraphical Abstract

    Super Enhancer-Associated circRNA-circLrch3 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis by Formation of R-Loop with Host Gene

    Western blotting, PI staining, and LDH release were used to explore the role of circLrch3 in pulmonary arterial smooth muscle cells pyroptosis.
    [International Journal of Biological Macromolecules]

    Abstract

    KLF15 Maintains Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Thoracic Aortic Dissection by Interacting with MRTFB

    Investigators explored unknown aspects of Krüppel-like factor 15 (KLF15) function. They found that KLF15 expression was reduced in human thoracic aortic dissection (TAD) samples and β-aminopropionitrile monofumarate (BAPN)-induced TAD mouse model.
    [Journal Of Biological Chemistry]

    Full Article
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    REVIEWS

    Post-Translational Modifications of Vertebrate Striated Muscle Myosin Heavy Chains

    The authors discuss myosin heavy chains post-translational modifications (PTMs) that have been biochemically and/or functionally studied in mammals’ and rodents’ striated muscles.
    [Cytoskeleton]

    Abstract
    INDUSTRY AND POLICY NEWS

    Solid Biosciences Receives Rare Pediatric Disease Designation from the FDA for Duchenne Muscular Dystrophy Gene Therapy Candidate SGT-003

    Solid Biosciences, Inc. announced that the US FDA has granted Rare Pediatric Disease Designation for SGT-003, the company’s next-generation Duchenne muscular dystrophy gene therapy candidate.
    [Solid Biosciences, Inc.]

    Press Release
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    JOB OPPORTUNITIES

    PhD Position – Age-Associated Muscle Weakness

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    Postdoctoral Positions – Biotechnology

    Sapienza University – Rome, Italy

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    Brown University – Providence, Rhode Island, United States

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    French National Institute for Health Research (INSERM) – Nantes, France

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