 | | Vol. 9.13 – 15 April, 2024 |
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| The authors leveraged two models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte-targeted delivery of reprogramming factors in adult mice to study cardiomyocyte dedifferentiation.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a 96-well plate assay which allowed fast, reproducible, and high-throughput generation of three dimensional cardiac rings around a deformable optically transparent hydrogel pillar of known stiffness.
[eLife] |
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| Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling. Metabolomic and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight, especially thiamine metabolism.
[Signal Transduction and Targeted Therapy] |
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| Scientists employed miRNA microarray analysis to investigate the expression profile of miRNAs in skeletal muscle from an animal model of hypoxia-induced muscle atrophy and resistance training aimed at mitigating muscle atrophy.
[Scientific Reports] |
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| Spontaneously hypertensive rats and newly generated smooth muscle–specific AKAP150 knockin mice were used to assess the role of myocyte AKAP150/CaV1.2 channel in regulating cerebral artery function after exercise intervention.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| Investigators harnessed publicly available human carotid atherosclerotic data to explore radical S-adenosyl-L-methionine domain containing 2 (RSAD2) in lesions and employed siRNA-mediated gene-knockdown to investigate its function in interferon gamma-stimulated human aortic smooth muscle cells.
[Scientific Reports] |
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| The authors lay a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explore other regulatory pathways, such as autophagy and inflammatory signaling.
[Molecular Medicine Reports] |
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| Advanced space biology continued aboard the International Space Station to develop and test therapies for a range of space-caused and Earthbound health conditions.
[NASA Blogs] |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Singapore Institute Of Technology – Singapore, Singapore |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | Sapienza University – Rome, Italy |
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| | Brown University – Providence, Rhode Island, United States |
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