 | | Vol. 9.15 – 29 April, 2024 |
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| Scientists generated a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Doxorubicin (DOX) exposure induced CDK7 activation in mouse heart and isolated cardiomyocytes. Cardiac-specific ablation of cyclin-dependent kinase 7 (CDK7) attenuated DOX-induced cardiac dysfunction and fibrosis.
[Cardiovascular Research] |
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| Investigators performed echocardiography, electrophysiology, intracellular Ca2+ imaging, and protein analysis. Female heart failure with preserved ejection fraction (HFpEF) mice exhibited more severe diastolic dysfunction.
[Cardiovascular Research] |
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| Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.
[Journal Of Clinical Investigation] |
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| To assess the effect of glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells and isolated mitochondria, researchers performed respiratory and metabolic studies in wildtype and CRISPR-generated GOT2 knockdown C2C12 myocytes.
[American Journal Of Physiology-Cell Physiology] |
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| Bioinformatics analysis was employed to screen for potential molecules and mechanisms associated with occurrence and development of pulmonary arterial hypertension.
[Respiratory Research] |
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| Calf vascular smooth muscle cells were administered tumor necrosis factor-alpha (TNF-α) before culturing in two- and three-dimensional well plates and polyglycolic acid scaffolds.
[Artificial Organs] |
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| The authors critically summarize the recent research progress on mitochondrial dynamics and mitophagy in skeletal muscle atrophy and expound on the intrinsic molecular mechanism of skeletal muscle atrophy caused by mitochondrial dynamics and mitophagy.
[Cellular & Molecular Biology Letters] |
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| Parent Project Muscular Dystrophy (PPMD) and Duchenne UK announced the recipient of their Joint Call for Therapeutic Projects. Professor Peter Kang MD, from the University of Minnesota, has been awarded the grant for his research project titled “Phase I clinical trial of myogenic progenitors for DMD.”
[Parent Project Muscular Dystrophy] |
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| May 7-11, 2024
Baltimore, Maryland, USA |
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| | NovoNordisk – Beijing, China |
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| | University of Florida – West Palm Beach, Florida, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Brown University – Providence, Rhode Island, United States |
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| | Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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