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| The authors examined the mechanism of CBX7-mediated repression of cardiomyocyte proliferation through coimmunoprecipitation, mass spectrometry, and other molecular techniques.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By using HeLa and HK-2 cell lines, human induced pluripotent stem cell-derived cardiomyocytes, and patient-derived primary fibroblasts, researchers showed that RRAGD auto-activating mutations lead to inhibition of TFEB and TFE3 nuclear translocation and transcriptional activity.
[Nature Communications] |
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| Long-term low-dose sulforaphane treatment of fibroblasts enhanced the release of anti-remodeling cardiomyocyte-targeted fibroblast-derived exosomes, which effectively prevented the onset of heart failure.
[Journal Of Translational Medicine] |
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| The authors presented protocols to illustrate the methods for conducting small-molecule-mediated differentiations of human induced pluripotent stem cells (hiPSCs) into cardiomyocytes, endothelial cells, and cardiac fibroblasts, as well as to assemble the fully integrated cardiac spheroids.
[Current Protocols] |
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| Given the roles of the SUR2 subunit of ATP-sensitive potassium (KATP) channels in all muscles, investigators sought to determine how myopathy arises using tissue-selective suppression of KATP, and found that loss-of-function in skeletal muscle, specifically, underlies myopathy.
[EMBO Molecular Medicine] |
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| The authors investigated a DMPK-promoter silencing strategy using CRISPR interference as a new alternative approach. Different sgRNAs targeting the DMPK promoter were evaluated in m yotonic dystrophy type 1 patient muscle cells.
[Molecular Therapy – Nucleic Acids] |
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| Scientists demonstrated that human scar-derived myofibroblasts dedifferentiatde into normal fibroblasts in response to pressure therapy, and identified how SMYD3/ITGBL1 contributed to the nuclear relay of mechanical signals.
[Developmental Cell] |
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| Vascular smooth muscle cells differentiated from cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) human induced pluripotent stem cells (hiPSCs) showed NOTCH3 deposition and abnormal actin cytoskeleton structure.
[Journal Of Genetics And Genomics] |
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| Investigators summarize the evidence on the effects of substrate availability on mitochondrial-sarcoplasmic reticulum (SR) interaction and mitochondria fusion/fission dynamics to modulate substrate oxidation in human skeletal muscle.
[Metabolism Clinical And Experimental] |
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| The authors describe the phenotypic diversity of smooth muscle cells and the different environmental cues that allow for the modulation of smooth muscle cell gene expression.
[Tissue Engineering Part B-Reviews] |
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| The FDA’s decision, expected by the end of the month, will have implications for how the agency regulates treatments like this one more broadly. It would be the first of its kind of medicine to get accelerated approval.
[CNN Health] |
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| June 12 – 15, 2023
EMBL Heidelberg and Virtual |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Heidelberg University Hospital – Heidelberg, Germany |
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| | Birkbeck, University of London – London, England, United Kingdom |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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