 | | Vol. 16.40 – 12 October, 2022 |
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| Investigators characterized a previously unidentified oncogenic lncRNA that mediated the integration of dysregulated epidermal growth factor receptor (EGFR) pathway with histone 2A (H2A) deubiquitination in glioblastoma tumorigenesis.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists presented that reactive astrocytes are critical for opioid-induced hyperalgesia development. They discovered Wnt5a was a neuron-to-astrocyte signal required for morphine-induced astrogliosis.
[Molecular Psychiatry] |
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| Researchers produced human telencephalic organoids from stem cell-derived single neural rosettes and investigated telencephalic development under normal and pathological conditions.
[Nature Communications] |
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| By utilizing Huntington’s disease models, scientists optimized siRNA compounds that exhibited selective silencing of mutant huntingtin proteins in patient-derived cells, demonstrating SNP-based allele-specific RNAi gene silencing in the central nervous system.
[Nature Communications] |
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| Investigators addressed the role of adhesion protein integrin α2, which was identified in a high-throughput screen for novel potential targets in glioblastoma cells treated with standard therapy consisting of temozolomide and radiation.
[Neuro-Oncology] |
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| Researchers showed that reduced EHMT1 activity decreased NRSF/REST protein, leading to abnormal neuronal gene expression and progression of neurodevelopment in human induced pluripotent stem cells.
[Translational Psychiatry] |
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| The authors investigated the effects of a fusion peptide that combined the kinase inhibitory region of SOCS3 and virus trans-activator of transcription on biological behavior of cultured neural stem cells under inflammatory conditions.
[CNS Neuroscience & Therapeutics] |
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| Scientists studied leucine-rich repeat kinase 2 (LRRK2) expression in the enteric nervous system and discovered LRRK2 was constitutively expressed in enteric glial cells in both fetal and adult tissues as well.
[Journal of Neurochemistry] |
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| The authors illustrate how multiple signaling pathways and systems may interact to provide a more comprehensive view of major depressive disorder’s neurobiology.
[Molecular Psychiatry] |
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| Investigators summarise the role of the receptor for hyaluronan-mediated motility (RHAMM) in brain development, focusing on the neural stem and progenitor cells, and discuss the current knowledge on RHAMM involvement in glioblastoma progression.
[British Journal of Cancer] |
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| AB Science SA announced that the first authorizations have been received to initiate its Phase III confirmatory study evaluating masitinib in patients with mild to moderate Alzheimer’s Disease from the French Medicine Agency together with AEMPS and EOF.
[AB Science SA] |
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| The Brain & Behavior Research Foundation awarded the 2022 Outstanding Achievement Prizes in Mental Health to five scientists for their extraordinary work in advancing psychiatric research.
[Brain & Behaviour Research Foundation] |
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| November 7-8, 2022
London, England, United Kingdom |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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| | Institute of Tissue Regeneration Engineering – Cheonan, South Korea |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | Laval University – Quebec City, Quebec, Canada |
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