A Critical Role for VEGF and VEGFR2 in NMDA Receptor Synaptic Function and Fear-Related Behavior Using a combination of electrophysiological, single-molecule imaging and conditional transgenic approaches, scientists identified the molecular basis of the vascular endothelial growth factor (VEGF) effect on synaptic transmission and plasticity. [Mol Psychiatry] Full Article The Autism-Associated MET Receptor Tyrosine Kinase Engages Early Neuronal Growth Mechanism and Controls Glutamatergic Circuits Development in the Forebrain Researchers showed that MET protein expression is dynamically regulated and compartmentalized in developing neurons. [Mol Psychiatry] Abstract Regulation of Neural Gene Transcription by Optogenetic Inhibition of the RE1-Silencing Transcription Factor By expressing AsLOV2 chimeras in Neuro2a cells, scientists achieved light-dependent modulation of REST target genes that was associated with an improved neural differentiation. In primary neurons, light-mediated REST inhibition increased Na+-channel 1.2 and brain-derived neurotrophic factor transcription and boosted Na+ currents and neuronal firing. [Proc Natl Acad Sci USA] Abstract | Full Article The p38 MAP Kinase Pathway Modulates the Hypoxia Response and Glutamate Receptor Trafficking in Aging Neurons Researchers found that loss of p38 MAP kinase (MAPK) impairs EGL-9 protein localization in neurons and activates the hypoxia-inducible transcription factor HIF-1, suggesting that p38 MAPK inhibits the hypoxia response pathway through EGL-9. [Elife] Abstract | Full Article YB-1 Is Elevated in Medulloblastoma and Drives Proliferation in Sonic Hedgehog-Dependent Cerebellar Granule Neuron Progenitor Cells and Medulloblastoma Cells Scientists report that Y-box binding protein-1 (YB-1), an onco-protein regulating transcription and translation, binds to insulin-like growth factor 2 promoter P3. They observed that YB-1 is upregulated across human medulloblastoma subclasses as well as in other varieties of pediatric brain tumors. [Oncogene] Abstract Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus Scientists characterized the morphology of radial glia-like cells, their molecular identity, proliferative activity, and fate determination in the adult mouse hippocampus. [Stem Cells] Abstract Signaling Pathway Models as Biomarkers: Patient-Specific Simulations of JNK Activity Predict the Survival of Neuroblastoma Patients Researchers characterized the network that regulated stress signaling by the c-Jun N-terminal kinase (JNK) pathway in neuroblastoma cells. [Sci Signal] Abstract CRISPR/Cas9 Facilitates Investigation of Neural Circuit Disease Using Human iPSCs: Mechanism of Epilepsy Caused by an SCN1A Loss-Of-Function Mutation By fluorescently labeling GABAergic subtype in iPSC-derived neurons using CRISPR/Cas9, researchers, for the first time performed electrophysiological studies on SCN1A-expressing neural subtype and monitored the postsynaptic activity of both inhibitory and excitatory types. [Transl Psychiatry] Full Article RPS23RG1 Reduces aβ Oligomer-Induced Synaptic and Cognitive Deficits Rps23rg1, a functional retroposed mouse gene, has been shown to reduce Alzheimer’s β-amyloid (Aβ) production and tau phosphorylation. Scientists have identified its human homolog, and demonstrated that RPS23RG1 regulates synaptic plasticity, thus counteracting Aβ oligomer (oAβ)-induced cognitive deficits in mice. [Sci Rep] Full Article PARP6 Is a Regulator of Hippocampal Dendritic Morphogenesis Researchers demonstrated that poly-ADP-ribose polymerase (PARP) 6, a neuronally enriched PARP that catalyzes mono-ADP-ribosylation, regulates hippocampal dendrite morphogenesis, a process that is critical for proper neural circuit formation during development. [Sci Rep] Full Article Effects of Calcitriol on Experimental Spinal Cord Injury in Rats Histological damage and neuron loss after spinal cord injury were reduced in calcitriol-treated rats, and functional recovery was significantly promoted in the calcitriol group compared with controls. [Spinal Cord] Abstract |