Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca2+ Homeostasis in Neural Stem Cell Development Investigators showed that Miro, a known component of the mitochondrial transport machinery, regulates Drosophila neural stem cell development through mitochondrial Ca2+ homeostasis control, independent of its role in mitochondrial transport. [Dev Cell] Abstract | Graphical Abstract Fine Processes of Nestin-GFP–Positive Radial Glia-Like Stem Cells in the Adult Dentate Gyrus Ensheathe Local Synapses and Vasculature The authors used light microscopy and electron microscopy to examine Nestin-GFP transgenic mice and provide a detailed ultrastructural reconstruction analysis of Nestin-GFP–positive radial glia-like cells of the dentate gyrus. They showed that their primary processes follow a tortuous path from the subgranular zone through the granule cell layer and ensheathe local synapses and vasculature in the inner molecular layer. [Proc Natl Acad Sci USA] Abstract WIP1 Modulates Responsiveness to Sonic Hedgehog Signaling in Neuronal Precursor Cells and Medulloblastoma Scientists found that PPM1D (WIP1) overexpression increased expression of Sonic Hedgehog (Shh) target genes and cell proliferation in response to Shh stimulation in NIH3T3 and cerebellar granule neuron precursor cells in a p53-independent manner. [Oncogene] Abstract Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage By integrating high-resolution methylomics, RNA-sequencing, and multiple transgenic lines, researchers defined the role of DNMT1 in developmental myelination. They detected hypermethylation of genes related to cell cycle and neurogenesis during differentiation of oligodendrocytes derived from progenitors (OPCs), yet genetic ablation of Dnmt1 resulted in inefficient OPC expansion and severe hypomyelination associated with ataxia and tremors in mice. [Cell Rep] Full Article | Graphical Abstract | Press Release PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells Researchers observed that human cytomegalovirus infection dramatically impaired the rate of neuronogenesis and strongly increased peroxisome proliferator-activated receptor gamma (PPARγ) levels and activity. Consistent with these findings, levels of 9-hydroxyoctadecadienoic acid, a known PPARγ agonist, were significantly increased in infected neural stem cells from human embryonic stem cells. [PLoS Pathog] Full Article Manifestation of Huntington’s Disease Pathology in Human Induced Pluripotent Stem Cell-Derived Neurons Generated Huntington’s disease GABAergic medium spiny-like neurons recapitulated disease pathology in vitro, as evidenced by mutant huntingtin protein aggregation, increased number of lysosomes/autophagosomes, nuclear indentations, and enhanced neuronal death during cell aging. [Mol Neurodegener] Full Article Connexin 43 in Astrocytes Contributes to Motor Neuron Toxicity in Amyotrophic Lateral Sclerosis Astrocytes isolated from SOD1G93A mice as well as human induced pluripotent stem cell-derived astrocytes showed an increase in connexin 43 protein, which was found to be an endogenous phenomenon independent of neuronal co-culture. [Glia] Abstract MHC-Class-II Are Expressed in a Subpopulation of Human Neural Stem Cells In Vitro in an IFNγ–Independent Fashion and during Development Comparative analysis of immunogenicity of human embryonic/fetal brain-derived neural stem cells and human mesenchymal stem cells with neurogenic potential from umbilical cord and pediatric adipose tissue, while highlighting differences in their immunogenicity, led the authors to discover subsets of neural cells co-expressing the neural marker SOX2 and major histocompatibility antigens class-2 (MHC-II) antigen in vivo during human CNS development. [Sci Rep] Full Article Effect of the PGD2-DP Signaling Pathway on Primary Cultured Rat Hippocampal Neuron Injury Caused By Aluminum Overload The agonists and antagonists of DP receptor were used to examine whether the PGD2-DP signaling pathway affects neuronal function. Primary cultured hippocampal neurons were prepared and treated with aluminum maltolate to establish the neuronal damage model. [Sci Rep] Full Article Phosphatidylcholine Protects Neurons from Toxic Effects of Amyloid β-Protein in Culture Researchers report the protective effect of phosphatidylcholine (PC) on primary cultured neurons against amyloid β-protein (Aβ)1-42-induced damage. Aβ1-42 caused neuronal death as demonstrated by lactose dehydrogenase release, which was completely prevented by a pretreatment with PC in a dose-dependent manner. [Brain Res] Abstract |