Vertical Transmission of Zika Virus Targeting the Radial Glial Cells Affects Cortex Development of Offspring Mice Scientists showed a vertical transmission of Zika virus (ZIKV) in mice and a marked effect on fetal brain development. They found that intraperitoneal injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. [Cell Res] Full Article The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing Investigators found that glioblastoma stem cells lack LIN28 and express both let-7 and their target genes, suggesting LIN28-independent protection from let-7 silencing. [Cell Rep] Full Article | Graphical Abstract Accumulation of Amyloid-β by Astrocytes Result in Enlarged Endosomes and Microvesicle-Induced Apoptosis of Neurons To examine the role of astrocytes in amyloid-β (Aβ) pathology, researchers added Aβ protofibrils to a co-culture system of primary neurons and glia. They demonstrated that astrocytes rapidly engulf large amounts of Aβ protofibrils, but then store, rather than degrade the ingested material. [Mol Neurodegener] Full Article A Triple–Effect Cocktail Produced by Neural Stem Cells as a Novel Neurorepair Therapy for Chronic Stage CNS Autoimmunity Scientists genetically engineered neural stem cells to produce a triply therapeutic cocktail comprising IL–10, NT–3, and LINGO–1–Fc, thus simultaneously targeting all mechanisms that underlie chronicity of multiple sclerosis in the central nervous system (CNS): persistent inflammation, loss of trophic support for oligodendrocytes and neurons, and accumulation of neuroregeneration inhibitors. [Mol Ther] Abstract Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium The authors describe a robust and simple method for generating cerebral organoids from human pluripotent stem cells by using a chemically defined hydrogel material and chemically defined culture medium. [Stem Cells Transl Med] Abstract The Neurofilament-Derived Peptide NFL-TBS.40-63 Targets Neural Stem Cells and Affects Their Properties Scientists showed that the NFL-TBS.40-63 peptide targets neural stem cells (NSCs) in vitro and in vivo when injected into the cerebrospinal fluid. Although neurosphere formation was not altered by the peptide, the NSC self-renewal capacity and proliferation were reduced and were associated with increased adhesion and differentiation. [Stem Cells Transl Med] Abstract Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells Researchers report that formylpeptide receptor 1 (Fpr1) and Fpr2 are expressed on neural stem cells (NSCs) as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. [Sci Rep] Full Article Physiological Maturation and Drug Responses of Human Induced Pluripotent Stem Cell-Derived Cortical Neuronal Networks in Long-Term Culture The authors revealed the feasibility of long-term multi-electrode arrays measurements from human induced pluripotent stem cell-derived neuronal networks in vitro for mechanistic analyses and drug screening. [Sci Rep] Full Article Influence of Folic Acid on Neural Connectivity during Dorsal Root Ganglion Neurogenesis To model the development of neural connectivity, the authors cultured dorsal root ganglia (DRGs) taken from eight-day-old chick embryos in a range of pteroylmonoglutamate concentrations. DRGs were cultured for 36 hours, fixed and immunostained to reveal the locations of neural networks with synaptic vesicles. [Cells Tissues Organs] Full Article |