Neural Cell News Volume 16.42 | Oct 26 2022

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    2022-10-26 | NCN 16.42


    Neural Cell News by STEMCELL Technologies
    Vol. 16.42 – 26 October, 2022
    TOP STORY

    Modeling Gene × Environment Interactions in PTSD Using Human Neurons Reveals Diagnosis-Specific Glucocorticoid-Induced Gene Expression

    Scientists compared transcriptional responses to hydrocortisone exposure in human-induced pluripotent stem cell-derived glutamatergic neurons and peripheral blood mononuclear cells from combat veterans with post-traumatic stress disorder and controls.
    [Nature Neuroscience]

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    PUBLICATIONSRanked by the impact factor of the journal

    Microglial Debris Is Cleared by Astrocytes via C4b-Facilitated Phagocytosis and Degraded via RUBICON-Dependent Noncanonical Autophagy in Mice

    Researchers investigated how dead microglia were removed and found that although microglia could phagocytose microglial debris in vitro, the territory-dependent competition hindered the microglia-to-microglial debris engulfment in vivo.
    [Nature Communications]

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    Epigenetic Upregulation of Schlafen11 Renders WNT- and SHH- Activated Medulloblastomas Sensitive to Cisplatin

    Investigators found Schlafen family member 11 (SLFN11) to be one of the top prognostic markers in medulloblastomas, and explored its expression and functions in medulloblastoma.
    [Neuro-Oncology]

    Abstract

    Activation of TRPV1 Receptor Facilitates Myelin Repair Following Demyelination via the Regulation of Microglial Function

    Researchers reported that transient receptor potential vanilloid 1 (TRPV1) expression was increased within the corpus callosum during demyelination in a cuprizone-induced demyelination mouse model.
    [Acta Pharmacologica Sinica]

    Abstract

    Transplanting Neurofibromatosis-1 Gene Knockout Neural Stem Cells Improve Functional Recovery in Rats with Spinal Cord Injury by Enhancing the mTORC2 Pathway

    Lentiviral vectors were used to knock out NF-1, Ricotr, the core member of mTORC2, or NF-1+Ricotr in neural stem cells in vitro and then were transplanted at the lesion site in a rat model of spinal cord injury.
    [Experimental & Molecular Medicine]

    Full Article

    Wide Spectrum of Neuronal and Network Phenotypes in Human Stem Cell-Derived Excitatory Neurons with Rett Syndrome-Associated MECP2 Mutations

    Investigators studied the effect of a novel MECP2 L124W missense mutation in the methyl-CpG binding domain of an atypical Rett syndrome patient with preserved speech in comparison to severe MECP2 null mutations.
    [Translational Psychiatry]

    Full Article

    Rapid Differentiation of hiPSCs into Functional Oligodendrocytes Using an OLIG2 Synthetic Modified Messenger RNA

    Researchers developed a synthetic modified messenger RNA-based reprogramming method that led to the generation of transgene-free oligodendrocytes.
    [Communications Biology]

    Full Article

    The Synergy of β Amyloid 1–42 and Oxidative Stress in the Development of Alzheimer’s Disease-Like Neurodegeneration of Hippocampal Cells

    Scientists compared the effects of Aβ 1-42 alone with that of Aβ-associated oxidative stress induced by the ferrous sulfate, Aβ, and buthionine sulfoximine cocktail on the neurodegeneration of hippocampal cells in vitro.
    [Scientific Reports]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    REVIEWS

    Incretin and Insulin Signaling as Novel Therapeutic Targets for Alzheimer’s and Parkinson’s Disease

    The authors provide a comprehensive review of the therapeutic potential of incretin mimetics and insulin in Alzheimer’s disease and Parkinson’s disease.
    [Molecular Psychiatry]

    Full Article

    Ectodermal Origins of the Skin-Brain Axis: A Novel Model for the Developing Brain, Inflammation, and Neurodevelopmental Conditions

    Investigators coalesce epidemiological and neuroinflammatory evidence linking cutaneous atopic disease with both reduced skin barrier integrity and determinants of neurodivergence.
    [Molecular Psychiatry]

    Full Article
    INDUSTRY AND POLICY NEWS

    Julia TCW, PhD, Receives BrightFocus Award

    Julia TCW, PhD, received a three-year, $300,000 grant from the BrightFocus Foundation. The award will fund her research project, “Modulation of astrocyte matrisome signals reprogram microglia that can be targeted to mitigate Alzheimer’s disease.”
    [Boston University Chobanian & Avedisian]

    Press Release

    Modifi Bio Receives $2.4 Million Award from National Cancer Institute to Advance Innovative Precision Oncology Platform

    Modifi Biosciences was selected by the National Cancer Institute for a Fast-Track Small Business Innovation Research Award of $2.4 million to further advance its novel precision oncology platform into the clinic, particularly for patients with brain cancer.
    [Modifi Biosciences (GlobeNewswire)]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting on Integrated Cell Tracking in Oncohematology

    November 10 – 12, 2022
    Bordeaux, France

    > See All Events

    JOB OPPORTUNITIES

    Center Director – Neuroscience

    Wake Forest University School of Medicine – Winston Salem, North Carolina, United States

    Postdoctoral Fellowship – Neurodegeneration and Neural Repair

    Yale University – New Haven, Connecticut, United States

    Senior Scientist – Receptor Pharmacology and Cell Signaling

    Novo Nordisk – Seattle, Washington, United States

    Postdoctoral Positions – Organoid Research

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    Assistant Professor – Neuroscience

    Salk Institute for Biological Studies – San Diego, California, United States

    > See All Jobs

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