Neural Cell News 14.12 April 1, 2020 | |
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TOP STORYMitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling Scientists showed that acute injury and blood-brain barrier disruption triggered the formation of a prominent mitochondrial-enriched compartment in astrocytic endfeet, which enabled vascular remodeling. [Cell Metab] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers showed that mice bearing human amyotrophic lateral sclerosis (ALS)-associated TBK1 missense loss-of-function mutations, or mice in which the Tbk1 gene was selectively deleted in motor neurons, did not display a neurodegenerative disease phenotype. [Neuron] Abstract | Graphical Abstract ECE2 Regulates Neurogenesis and Neuronal Migration During Human Cortical Development Investigators showed that manipulation of endothelin-converting enzyme-2 (ECE2) levels in human cerebral organoids and in the developing mouse cortex led to ectopic localisation of neural progenitors and neurons. [EMBO Rep] Full Article | Graphical Abstract Morphological analyses of NvPOU4 mutants crossed to transgenic reporter lines showed that the loss of NvPOU4 did not affect the initial specification of neural cells. [Cell Rep] Full Article | Graphical Abstract The authors provide evidence for the molecular mechanism that underlied a switch in the state of neocortical neural stem cells (NSCs). They showed that, at around E16.5, mouse neocortical NSCs started to generate GSX2-expressing intermediate progenitor cells. [Cell Rep] Full Article | Graphical Abstract rQNestin34.5v.2 dephosphorylated eIF-2α in human glioma cells, but not in human normal cells, resulting in significantly higher cytotoxicity and viral replication in the former compared to the latter. [Mol Ther Methods Clin Dev] Abstract | Graphical Abstract Scientists investigated the role of connector enhancer of kinase suppressor of Ras 2 (CNK2) in neurons in order to contribute to the understanding of how CNK2 alterations might cause developmental defects, and they have elucidated a functional role for CNK2 in the molecular processes that govern morphology of the postsynaptic density. [Sci Rep] Full Article PABPC5 and HCG15 were highly expressed in glioma cells. ZNF331 was lowly expressed. PABPC5 bound HCG15 to increase its stability. [Mol Ther Oncolytics] Abstract | Graphical Abstract TRBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via LINC00673/MAFF Pathway Researchers found RBFOX1 was downregulated in glioma vascular endothelial cells derived from glioma tissues, and in glioma endothelial cells obtained by co-culturing endothelial cells with glioma cells. [Mol Ther Oncolytics] Abstract | Graphical Abstract Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses Scientists found that presynaptic release probability was significantly increased in Ip6k1-knockout neurons, implying enhanced activity-dependent synaptic vesicle exocytosis. Expression of wild-type but not catalytically inactive IP6K1 in the Ip6k1-knockout hippocampus restored the altered presynaptic release probability. [iScience] Abstract | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News. | |
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REVIEWSThe authors provide a comprehensive overview of the effects of a total of 14 individual drugs (among which are seven type 2 diabetes mellitus drug types) against Alzheimer’s disease. [Trends Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the neural cell research field. | |
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INDUSTRY NEWSNeuBase Therapeutics, Inc. announced positive pre-clinical data from its pharmacokinetics studies in non-human primates and in vitro pharmacodynamics data in patient-derived cell lines. [NeuBase Therapeutics, Inc.] Press Release ImStem Biotechnology, Inc. announced that the FDA has lifted the clinical hold and cleared the Investigational New Drug application to evaluate IMS001 for the treatment of multiple sclerosis. [ImStem Biotechnology (PR Newswire Association LLC)] Press Release | |
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POLICY NEWSCull, Release or Bring Them Home: Coronavirus Crisis Forces Hard Decisions for Labs with Animals As universities scale back operations and scientists observe stay-at-home orders, many are struggling to protect their research and the animals that power it. [Nature News] Editorial Tens of Thousands of Scientists Are Redeploying to Fight Coronavirus As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technologist – Cancer Pain Treatment (Johns Hopkins University) NEW Postdoctoral Position – Neuroimmunology (LMU University Hospital Munich) NEW Postdoctoral Position – iPSC Models in Neurodegeneration (Flanders Institute for Biotechnology) Assistant Professor – Department of Neuroscience (Univeristy of Padua Department of Neusciences) Postdoctoral Fellow – Developmental Neuroscience (Children’s National Hospital) Research Assistant – Cerebral Organoids (Weill Cornell Medicine College) Postdoctoral Fellow – Neuroscience Research (University of North Carolina at Charlotte) Associate Professor – Visual Neuroscience (Dalhousie University) Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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