Neural Cell News Volume 14.22 | Jun 10 2020

TOP STORY

Three-Dimensional Bioprinted Glioblastoma Microenvironments Model Cellular Dependencies and Immune Interactions

To parse the function of macrophages in 3D, scientists compared the growth of glioblastoma stem cells alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel, with or without macrophage. [Cell Res] Abstract

(Ranked by impact factor of the journal)

Chemical Inhibition of FBXO7 Reduces Inflammation and Confers Neuroprotection by Stabilizing the Mitochondrial Kinase PINK1

BC1464 conferred neuroprotection in primary cortical neurons, human neuroblastoma cells, and patient-derived cells in several culture models of Parkinson’s disease. [J Clin Invest] Full Article

Cell-Type Specific Modulation of NMDA Receptors Triggers Antidepressant Actions

Investigators demonstrated that rapastinel directly enhanced NMDAR activity on principal glutamatergic neurons in medial prefrontal cortex without any effect on glutamate efflux. [Mol Psychiatry] Abstract

Rapid and Efficient Invasion Assay of Glioblastoma in Human Brain Organoids

Scientists demonstrated an array of methods that allowed rapid and efficient assaying of glioma stem cells invasion in human brain organoids. [Cell Rep] Full Article | Graphical Abstract

TNF-Alpha-Induced Microglia Activation Requires miR-342: Impact on NF-kB Signaling and Neurotoxicity

Co-cultures of microglia with hippocampal neurons, using a microfluidic system, were performed to understand the impact on neurotoxicity. [Cell Death Dis] Full Article

Characterization of a New Small-Molecule Inhibitor of HDAC6 in Glioblastoma

Transcriptomic analysis of patient-derived glioma stem cells revealed an increase in cell differentiation and cell death pathways, as well as a decrease in cell-cycle activity and cell division by the treatment with the compound. [Cell Death Dis] Full Article

VCAM1 Labels a Subpopulation of Neural Stem Cells in the Adult Hippocampus and Contributes to Spatial Memory

By injecting virus into Ai14 reporter mice to conduct lineage tracing in the adult dentate gyrus, investigators confirmed that vascular cell adhesion molecule 1 (VCAM1)-expressing cells were multipotent and capable of generating neurons and astrocytes. [Stem Cell Reports] Full Article | Graphical Abstract

Human Cerebrospinal Fluid Promotes Neuronal Circuit Maturation of Human Induced Pluripotent Stem Cell-Derived 3D Neural Aggregates

The authors demonstrated that human cerebrospinal fluid rapidly triggered neurogenesis, gliogenesis, synapse formation, neurite outgrowth, suppressed proliferation of residing neural stem cells. [Stem Cell Reports] Full Article | Graphical Abstract

SHP2 Mutations Induce Precocious Gliogenesis of Noonan Syndrome-Derived iPSCs During Neural Development In Vitro

Neural cells developed from noonan syndrome-neural precursor cells exhibited abundancy of the glial cells, neurites of neuronal cells, and low electrophysiological property. [Stem Cell Res Ther] Full Article

A Unique Hybrid Characteristic Having Both Pro- and Anti-Inflammatory Phenotype Transformed by Repetitive Low-Dose Lipopolysaccharide in C8-B4 Microglia

To characterize repetitive low-dose lipopolysaccharide (REPELL)-microglia, the gene expression and phagocytic activity of REPELL-microglia were analyzed with the murine C8-B4 microglia cell line. [Sci Rep] Full Article

Comparative Effects of Alpha- and Gamma-Tocopherol on Mitochondrial Functions in Alzheimer’s Disease In Vitro Model

Researchers compared the effects of alpha-tocopherol and gamma-tocopherol on their ability to reduce Aβ level, modulate mitochondrial function and reduce the apoptosis marker in SH-SY5Y cells stably transfected with the wild-type or mutant form of the amyloid precursor protein gene. [Sci Rep] Full Article

Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & ESC & iPSC News.

Strategies and Prospects of Effective Neural Circuits Reconstruction after Spinal Cord Injury

The authors summarize the recent progress in biological and engineering strategies for reconstructing neural circuits and promoting functional recovery after spinal cord injury. [Cell Death Dis] Full Article

Visit our reviews page to see a complete list of reviews in the neural cell research field.

AMERI Holdings Amalgamation Partner Jay Pharma Reports IRB Approval For Testing Proprietary CBD Formulation In Brain Cancer

AMERI Holdings, Inc. announced that its proposed amalgamation partner Jay Pharma Inc. received institutional review board approval by Rabin Medical Center in Petah Tikva, Israel for a Phase I/II clinical trial investigating Jay Pharma’s proprietary cannabidiol (CBD) formulation for the treatment of glioblastoma multiforme. [AMERI Holdings, Inc. (PR Newswire Association LLC)] Press Release

Karyopharm Announces Dosing of First Patient in a Phase I/II Study of Selinexor in Combination with Standard of Care Therapy for Patients with Newly Diagnosed or Recurrent Glioblastoma

Karyopharm Therapeutics, Inc. announced dosing of the first patient in a Phase I/II clinical study evaluating oral selinexor in combination with standard of care therapy in patients with newly diagnosed or recurrent glioblastoma. [Karyopharm Therapeutics, Inc.] Press Release

As Pandemic Pounds US Universities, Federal Support Helps Their Labs Stay Afloat

This spring, as the coronavirus pandemic shuttered US higher education, many college presidents began to warn of the dire financial impact of a frozen US economy on their institutions. Their mix of revenue sources largely determined how much they might be hurt. [ScienceInsider] Editorial

As the Pandemic Hits Campus Finances, Faculty Face Layoffs

The pandemic has bored holes in budgets at universities and colleges across the US and beyond. To stem the spread of the coronavirus, higher education institutions shuttered their campuses, sent students home, and moved classes online. [The Scientist] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

We are suspending new event postings in our newsletters and on Twitter.
We will strive to keep our current event listings updated with event status.
We encourage you to visit event sites directly for updates.

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Brain Models for Neurodegenerative Diseases (F. Hoffmann-La Roche AG)

Scientific Leader – Neuroscience and Technology Translation (Simon Fraser University)

Tenure-Track Investigator – Computational Neuroscientist (NIH National Institute of Mental Health)

Research Group Leader – Neuroscience (Werner Reichardt Centre for Integrative Neuroscience)

Postdoctoral Fellow – Genes in Neural Circuits (Cold Spring Harbor Laboratory)

Postdoctoral Position – Electron Microscopy of Brain Circuits (Technical University of Munich)

Investigator Scientist – Brain Neuron Research (The MRC Laboratory of Molecular Biology)

Postdoctoral Position – Ferroptosis Research in Neuroblastoma (Flanders Institute for Biotechnology)

Postdoctoral Associate – Neurobiology Research (Cornell University)

Associate Professor – Molecular Neurobiology (Aarhus University)

Postdoctoral Fellow – Neurogenerative Disease (Johns Hopkins University School of Medicine)

Postdoctoral Program – Aging and Alzheimer’s Disease Research (Huntington Medical Research Institutes)

Postdoctoral Associate – Neuron Diversity Mechanisms in Brain Development (Howard Hughes Medical Institute)

Faculty Positions – Brain Disorders (IDG/McGovern Institute for Brain Research)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Neural Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.