 | | Vol. 14.33 – 2 September, 2020 |
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| Investigators identified interferon-induced transmembrane protein 3 (IFITM3) as a γ-secretase modulatory protein, and established a mechanism by which inflammation affected the generation of amyloid-β.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report the role of endogenous neuropeptide cholecystokinin (CCK), released from dentate CCK interneurons, in regulating neurogenic niche cells and neural stem cells.
[Neuron] |
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| Macrophage receptor with collagenous structurehigh TAMs induced a phenotypic shift towards mesenchymal cellular state of glioma stem cells, promoting both invasive and proliferative activities, as well as therapeutic resistance to irradiation.
[Genome Biology] |
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| Researchers investigated the expression and cellular localization of Musashi (MSI)1 and MSI2 in the brain tissues of Alzheimer’s disease, amyotrophic lateral sclerosis and frontotemporal dementia.
[Nature Communications] |
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| The authors report that developmental anoikis distinguished the pathological detachment of progenitor cells from the normal delamination of daughter neuroblasts in the developing mouse neocortex.
[Nature Communications] |
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| Expressed in specific regions of the human developing and adult brain, ZNF417/587 kept controlling transposable element-embedded regulatory sequences in embryonic stem cells-derived neurons and brain organoids.
[Science Advances] |
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| Scientists showed that a Düsseldorf isolate of SARS‐CoV‐2 entered 3D human brain organoids within two days of exposure. They identified that SARS‐CoV‐2 preferably targeted neurons of brain organoids.
[EMBO Journal] |
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| Researchers report that age-related loss of the posttranslational modification, O-linked β-N-acetylglucosamine, in neural stem cells promoted a glial fate switch.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| In isocitrate dehydrogenase 1-mutant glioma cells, the elevated 24(S)-hydroxycholesterol activated liver X receptors, which consequently accelerated the low-density lipoprotein receptor (LDLR) degradation by upregulating the inducible degrader of the LDLR.
[Oncogene] |
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| The authors reveal an important role for astrocytes in Parkinson’s disease pathology and highlight the potential of iPSC-derived cells in disease modeling and drug discovery.
[Scientific Reports] |
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| Researchers describe experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks.
[Nature Reviews Neuroscience] |
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| Scientists summarize the current understanding of the crucial role of δ-secretase in driving and spreading Alzheimer’s disease (AD) pathologies by cleaving multiple critical players, including APP and Tau, supporting that blockade of δ-secretase may provide an innovative disease-modifying therapeutic strategy for treating AD.
[Experimental and Molecular Medicine] |
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| The authors summarize some of the epigenetic pathways that have been shown to be active in three different primary brain tumors, glioblastoma, medulloblastoma, and diffuse intrinsic pontine glioma.
[Neurobiology of Disease] |
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| Enigma Biomedical Group announced execution of a Master Development, License and Option Agreement and two Project Agreements to evaluate novel neuroimaging biomarkers from Janssen Pharmaceutica N.V.
[Enigma Biomedical Group (BusinessWire, Inc.)] |
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| September 24 2020
Virtual |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Klinikum rechts der Isar of the Technische Universität München – Munich, Germany |
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