Neural Cell News Volume 14.34 | Sep 9 2020

May 12, 2022

NCN 14.34 | 9 Sept 2020

Neural Cell News by STEMCELL Technologies

Vol. 14.34 – 9 September, 2020

TOP STORY

A
Synthetic Synaptic Organizer Protein Restores Glutamatergic Neuronal Circuits

Researchers designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1.
[Science]

Full Article

STEMCELL's Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells.

PUBLICATIONSRanked by the impact factor of the journal

A
Patient-Based Model of RNA Mis-Splicing Uncovers Treatment Targets in Parkinson’s Disease

Using a patient-based in vitro model of PARK7-linked Parkinson’s disease, researchers identified a U1-dependent splicing defect causing a drastic reduction in DJ-1 protein and, consequently, mitochondrial dysfunction.
[Science Translational Medicine]

Abstract

Wrapping
Glia Regulates Neuronal Signaling Speed and Precision in the Peripheral Nervous System of Drosophila

Investigators used the peripheral nervous system of Drosophila larvae to determine how glia regulates axonal properties.
[Nature Communications]

Full Article

YAP-Mediated
Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma

Scientists performed genetic manipulation of Yes-Associated Protein (YAP) in human-derived neuroblastoma cell lines to investigate YAP function in key aspects of the malignant phenotype, including mesenchymal properties, tumor growth, chemotherapy response, and MEK inhibitor response.
[Cancer Research]

Abstract

RPS23RG1
Modulates Tau Phosphorylation and Axon Outgrowth through Regulating p35 Proteasomal Degradation

Both downregulation of p35 and the Cdk5 inhibitor roscovitine attenuated tau hyperphosphorylation and axon outgrowth impairment in Rps23rg1 knockout neurons.
[Cell Death & Differentiation]

Abstract

mTOR
Signaling Regulates the Morphology and Migration of Outer Radial Glia in Developing Human Cortex

Investigators found that dysregulation of mTOR signaling specifically affects outer radial glial cells, but not other progenitor types, by changing the actin cytoskeleton through the activity of the Rho-GTPase, CDC42.
[eLife]

Full Article

Attenuation
of the Extracellular Matrix Restores Microglial Activity during the Early Stage of Amyloidosis

Two‐photon vital microscopy demonstrated normal morphology and resting motility of microglia but strongly diminished number of microglial cells that migrated to the photolesion site in 5xFAD mice.
[Glia]

Full Article

RBPJ
Contributes to the Malignancy of Glioblastoma and Induction of Proneural-Mesenchymal Transition via IL-6-STAT3 Pathway

Researchers knocked down immunoglobulin kappa J region (RBPJ) expression in two glioblastoma (GBM) cell lines and four GBM stem‐like cell lines derived from surgical samples of GBM to investigate the effect on cell proliferation, invasion, stemness, and tumor formation ability.
[Cancer Science]

Abstract

Inhibition
of Purinergic P2X Receptor 7 (P2X7R) Decreases Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Expression in U251 Glioblastoma Cells

Scientists investigated the potential mechanism linking P2X7R and GM-CSF in the U251 glioblastoma cell line and the therapeutic potential of P2X7R antagonism in this setting.
[Scientific Reports]

Full Article

Feasibility
of Intracerebrally Administering Multiple Doses of Genetically Modified Neural Stem Cells to Locally Produce Chemotherapy in Glioma Patients

Investigators suggested intracerebral administration of serial doses of cytosine deaminase neural stem cells (CD-NSCs) was safe and feasible and identified a recommended dose for Phase II testing of 150 × 10⁶ CD-NSCs.
[Cancer Gene Therapy]

Abstract

Webinar on brain-region-specific organoids and assembloids by Dr. Sergiu Pasca

REVIEWS

New
Hints Towards a Precision Medicine Strategy for IDH Wild-Type Glioblastoma

The authors discuss recent treatment approaches and ongoing trials in the IDH-wildtype glioblastoma setting, and propose an integrated discovery stratagem incorporating multi-omics, single cell technologies and computational approaches.
[Annals of Oncology]

Abstract

CHIP as a Therapeutic Target for Neurological Diseases

Scientists discuss the possible molecular mechanisms that contribute to the pathogenesis of neurological diseases in which carboxy-terminus of Hsc70-interacting protein (CHIP) has a pivotal role, such as stroke, intracerebral hemorrhage, Alzheimer’s disease, Parkinson’s disease, and polyglutamine diseases.
[Cell Death & Disease]

Full Article

INDUSTRY AND POLICY NEWS

Zion
Pharma Announces Initiation of Phase I Study

Zion Pharma Limited announced the initiation of its Phase I study, in the United States, for its lead program ZN-A-1041. ZN-A-1041, is a best-in-class, small molecule tyrosine kinase receptor inhibitor targeting HER2.
[Zion Pharma Limited (BusinessWire, Inc.)]

Press Release

Randomized,
Open-Label, Multi-Center, Dose Optimization Study Expected to Evaluate 80 Patients with Mild- to Moderate-Stage ALS

AZTherapies, Inc. announced the dosing of the first patient in its Phase IIa clinical trial examining the safety and efficacy of ALZT-OP1a in patients with mild- to moderate-stage Amyotrophic Lateral Sclerosis (ALS).
[AZTherapies, Inc.]

Press Release

FEATURED EVENT

A
Synthetic Synaptic Organizer Protein Restores Glutamatergic Neuronal Circuits

A
Patient-Based Model of RNA Mis-Splicing Uncovers Treatment Targets in Parkinson’s Disease

Wrapping
Glia Regulates Neuronal Signaling Speed and Precision in the Peripheral Nervous System of Drosophila

YAP-Mediated
Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma

RPS23RG1
Modulates Tau Phosphorylation and Axon Outgrowth through Regulating p35 Proteasomal Degradation

mTOR
Signaling Regulates the Morphology and Migration of Outer Radial Glia in Developing Human Cortex

Attenuation
of the Extracellular Matrix Restores Microglial Activity during the Early Stage of Amyloidosis

RBPJ
Contributes to the Malignancy of Glioblastoma and Induction of Proneural-Mesenchymal Transition via IL-6-STAT3 Pathway

Inhibition
of Purinergic P2X Receptor 7 (P2X7R) Decreases Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Expression in U251 Glioblastoma Cells

Feasibility
of Intracerebrally Administering Multiple Doses of Genetically Modified Neural Stem Cells to Locally Produce Chemotherapy in Glioma Patients

New
Hints Towards a Precision Medicine Strategy for IDH Wild-Type Glioblastoma

CHIP as a Therapeutic Target for Neurological Diseases

Zion
Pharma Announces Initiation of Phase I Study

Randomized,
Open-Label, Multi-Center, Dose Optimization Study Expected to Evaluate 80 Patients with Mild- to Moderate-Stage ALS

Channels
in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

> See All Events

Research
Fellow Position – Biophysical Cell Analysis in Neural Stem Cells

Project Officer – Spinal Cord Injury and Neural Tissue Engineering

Postdoctoral Research Fellow – Molecular Neuroscience

Postdoctoral Research Fellow – Brain Tumor Dormancy/Metastasis

Research
Fellow Position – Neural Cell Therapy

> See All Jobs