Neural Cell News Volume 14.38 | Oct 7 2020

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    2020-10-7 | NCN 14.38


    Neural Cell News by STEMCELL Technologies
    Vol. 14.38 – 7 October, 2020
    TOP STORY

    Amygdala Inhibitory Neurons as Loci for Translation in Emotional Memories

    Scientists applied intersectional chemogenetic strategies to inhibitory neurons in the centrolateral amygdala of mice to block cell-type-specific translation programs that were sensitive to depletion of eukaryotic initiation factor 4E and phosphorylation of eukaryotic initiation factor 2α.
    [Nature]

    AbstractPress Release

    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    PUBLICATIONSRanked by the impact factor of the journal

    A Latent Lineage Potential in Resident Neural Stem Cells Enables Spinal Cord Repair

    Researchers uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the injured mouse spinal cord.
    [Science]

    AbstractPress ReleaseGraphical Abstract

    The Cross-Talk of Energy Sensing and Mitochondrial Anchoring Sustains Synaptic Efficacy by Maintaining Presynaptic Metabolism

    Scientists revealed an energy signalling axis that controlled presynaptic mitochondrial maintenance.
    [Nature Metabolism]

    AbstractPress Release

    Patient-Derived Organoids and Orthotopic Xenografts of Primary and Recurrent Gliomas Represent Relevant Patient Avatars for Precision Oncology

    Investigators report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient.
    [Acta Neuropathologica]

    Full ArticlePress Release

    Epigenetic Modulator Inhibition Overcomes Temozolomide Chemoresistance and Antagonizes Tumor Recurrence of Glioblastoma

    Scientists identified a specific glioblastoma multiforme stem-like cells subset and showed that activity of these cells was positively regulated by stabilization of methyl CpG binding domain 3 protein.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Glioma-Derived IL-33 Orchestrates an Inflammatory Brain Tumor Microenvironment that Accelerates Glioma Progression

    Researchers identified the dual function cytokine IL-33 as an orchestrator of the glioblastoma microenvironment that contributed to tumorigenesis.
    [Nature Communications]

    Full Article

    NBS1 Interacts With Notch Signaling in Neuronal Homeostasis

    Nbs1 deletion was dispensable for postmitotic neurons, but compromised their arborization and migration due to dysregulated Notch signaling.
    [Nucleic Acids Research]

    Full Article

    Extrahypothalamic Oxytocin Neurons Drive Stress-Induced Social Vigilance and Avoidance

    Scientists inhibited oxytocin synthesis in a stress-sensitive population of oxytocin neurons specifically within the medioventral bed nucleus of the stria terminalis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Astroglial FMRP Deficiency Cell-Autonomously Up-Regulates miR-128 and Disrupts Developmental Astroglial mGluR5 Signaling

    The authors showed that selective loss of astroglial fragile X mental retardation protein (FMRP) in vivo up-regulated a brain-enriched miRNA, miR-128-3p, in mouse and human FMRP-deficient astroglia, which suppressed developmental expression of astroglial metabotropic glutamate receptor 5, a major receptor in mediating developmental astroglia to neuron communication.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Peli1 Impairs Microglial Aβ Phagocytosis Through Promoting C/EBPβ Degradation

    Scientists found that the E3 ubiquitin ligase Pellino 1 (Peli1) was induced in the microglia of Alzheimer’s disease (AD)-like five familial AD mice, whose phagocytic efficiency for Aβ was then impaired, and therefore Peli1 depletion suppressed the Aβ deposition in the brains of 5×FAD mice.
    [PLOS Biology]

    Full Article

    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

    Researchers showed that PTEN-deficient glioblastomas largely depended on p110α for proliferation and p110β for migration.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Her 'mini-brains' creation was unexpected. Her protocol was groundbreaking. Watch Madeline Lancaster's webinar.
    REVIEWS

    Fibronectin in Development and Wound Healing

    Investigators outline fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronectin and concludes by discussing potential future directions to modulate fibronectin function in development and wound healing.
    [Advanced Drug Delivery Reviews]

    Full Article

    Tau at the Interface Between Neurodegeneration and Neuroinflammation

    The authors review the current knowledge on tau regulation and function in health and disease. In particular, they address its emerging role in connecting neurodegenerative and neuroinflammatory processes.
    [Genes & Immunity]

    Abstract

    Organotypic Models to Study Human Glioblastoma – Studying the Beast in its Ecosystem

    Investigators present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Neurotrope Announces First Patient Dosed in Long-Term Clinical Trial of Bryostatin in Alzheimer’s Disease

    Neurotrope, Inc. announced dosing of the first patient in its ongoing, long-term Phase II study of Bryostatin-1 for the treatment of Alzheimer’s disease. The study was conducted in collaboration with the National Institutes of Health under a $2.7 million grant to Neurotrope, Inc.
    [Neurotrope, Inc. (PR Newswire LLC)]

    Press Release

    Y-mAbs’ Nivatrotamab for the Treatment of Patients with Neuroblastoma Granted Orphan Drug Designation and Rare Pediatric Disease Designation by FDA

    Y-mAbs Therapeutics, Inc. announced that the FDA granted Orphan Drug Designation and Rare Pediatric Disease Designation for its leading bispecific antibody program nivatrotamab for the treatment of neuroblastoma.
    [Y-mAbs Therapeutics, Inc.]

    Press Release

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    JOB OPPORTUNITIES

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    Medical University of South Carolina – Charleston, South Carolina, United States

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    Howard Hughes Medical Institute – Ashburn, Virginia, United States

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    The University of British Columbia – Vancouver, British Columbia, Canada

    Laboratory Head – Neuroimmunology

    F. Hoffmann-La Roche AG – Basel, Switzerland

    Lab Manager – Neuroscience

    Yale University – New Haven, Connecticut, United States

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