 | | Vol. 14.41 – 28 October, 2020 |
| |
|
|
| Investigators showed two populations of projection neurons that expressed the structurally related G-protein-coupled receptors, TACR1 and GPR83 form parallel ascending circuit modules that cooperate to convey thermal, tactile and noxious cutaneous signals from the spinal cord to the lateral parabrachial nucleus of the pons.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
Applying multimodal single-cell analyses, scientists elucidated a heterogeneous but spatially defined central nervous system (CNS)-myeloid response during brain metastasis (br-met) outgrowth. They found Ccr2+ bone-marrow-derived myeloid cells minimally influenced br-met while CNS-myeloid promoted br-met outgrowth.
[Cell] |
| | Researchers generated developmental cortical interneurons — which are known to be affected in schizophrenia (SCZ) when matured — from induced pluripotent stem cells derived from healthy controls and individuals with SCZ and co-cultured them with or without activated microglia.
[Nature Neuroscience] |
|
|
|
| Using a model of cutaneous allergen exposure, investigators showed that allergens directly activated TRPV1+ sensory neurons leading to itch and pain behaviors.
[Immunity] |
|
|
|
| Researchers showed that the differentiation of neural stem cells into neurons could be accelerated by circularly polarized photons when DNA-bridged chiral assemblies of gold nanoparticles were entangled with the cells’ cytoskeletal fibres.
[Nature Biomedical Engineering] |
|
|
|
| The authors found that, in injured optic nerves, oligodendrocyte precursor cells undergone transient proliferation but failed to differentiate into mature myelination-competent oligodendrocytes, reminiscent of what was observed in human progressive multiple sclerosis.
[Neuron] |
|
|
|
| Researchers describe a method to generate oligodendrocyte precursor cells from human pluripotent stem cells in only ~20 days, which could subsequently myelinate neurons, both in vitro and in vivo.
[Nature Protocols] |
|
|
|
| Investigators profiled microglia differentiated from isogenic, CRISPR-modified TREM2-knockout induced pluripotent stem cell lines.
[Nature Communications] |
|
|
|
| Scientists showed that three transcription factors, Ascl1, Brn3b, and Isl1, efficiently converted fibroblasts into retinal ganglion cell-like neurons (iRGCs). The competence of cells to enter iRGC reprogramming route was determined by the cell-cycle status at a very early stage of the process.
[Stem Cell Reports] |
|
|
|
| Researchers generated in vitro neurodevelopmental disorder models including human induced pluripotent stem cell based monolayer neuronal differentiation, 3D neuroepithelial bud, and 3D cerebral organoid to study fetal brain development and the potential neuropathological effects induced by the HSV-1 infections.
[PLoS Pathogens] |
|
|
|
| Using transcriptomics and qPCR analyses in SH-SY5Y neuroblastoma cells, hypothalamic and hippocampal cell line, scientists identified cell type-specific and subfamily member-specific targets for PEA3 transcription factor subfamily.
[Scientific Reports] |
|
|
|
| Investigators implemented a xenograft model of patient-derived neuroblastoma organoids with differential GD2 expression and showed that even low GD2 expressing tumors still provided an adequate real-time fluorescence signal.
[Scientific Reports] |
|
|
|
|
| The authors discuss how the recently defined functions of these Alzheimer’s disease (AD) risk genes can be targeted therapeutically to modulate microglial cell state and slow the progression of AD.
[Neuron] |
|
|
|
| Investigators review the current understanding of the mechanisms that govern the biogenesis, transport, and assembly of the key components for presynaptic neurotransmission, discuss how alterations in presynaptic assembly may impact nervous system function or lead to disease, and outline key open questions for future research.
[Neuron] |
|
|
|
|
| Accuray, Inc. announced a collaboration with Brainlab, that will enhance and expand the Accuray CyberKnife® treatment platform for the neuro-radiosurgery market.The two companies partnered to provide the neuro-radiosurgery community with access to Brainlab Elements planning software, which will provide contouring capabilities optimized for neurosurgeons.
[Accuray, Inc.] |
|
|
|
| Prevail Therapeutics Inc. announced that the FDA has granted Fast Track designation for the Company’s experimental gene therapy program, PR001, for the treatment of neuronopathic Gaucher disease. The Company expects to initiate enrollment of the PROVIDE Phase I/II clinical trial of PR001 for Type 2 neuronopathic Gaucher disease patients in the second half of 2020.
[Prevail Therapeutics, Inc.] |
|
|
|
|
| November 11 – November 13
Virtual |
|
|
|
|
|
| | Edward Via College of Osteopathic Medicine – Blacksburg, Virginia, United States |
|
|
|
| | Cleveland Clinic – Cleveland, Ohio, United States |
|
|
|
| | NYU Shanghai – Shanghai, China |
|
|
|
| | German Center for Neurodegenerative Diseases – Bonn, Germany |
|
|
|
| | Boston University – Boston, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
