Neural Cell News Volume 15.1 | Mar 17 2021

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    2021-03-17 | NCN 15.1


    Neural Cell News by STEMCELL Technologies
    Vol. 15.1 – 17 March, 2021
    TOP STORY

    Primate Cell Fusion Disentangles Gene Regulatory Divergence in Neurodevelopment

    Scientists developed a new platform to address the limitations by fusing human and chimpanzee induced pluripotent stem cells to generate a panel of tetraploid hybrid stem cells.
    [Nature]

    Abstract

    Her 'mini-brains' creation was unexpected. Her protocol was groundbreaking. Watch Madeline Lancaster's webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Atlas of Early Human Brain Development Highlights Heterogeneity of Human Neuroepithelial Cells and Early Radial Glia

    Investigators found that organoid systems displayed low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses.
    [Nature Neuroscience]

    Full Article

    Activation of the p11/SMARCA3/Neurensin-2 Pathway in Parvalbumin Interneurons Mediates the Response to Chronic Antidepressants

    The authors report that the p11/SMARCA3 complex repressed Neurensin-2 transcription in hippocampal parvalbumin-expressing interneurons after chronic treatment with Selective Serotonin Reuptake Inhibitors.
    [Molecular Psychiatry]

    Full Article

    Integration of Alzheimer’s Disease Genetics and Myeloid Genomics Identifies Disease Risk Regulatory Elements and Genes

    Scientists showed that Alzheimer’s disease risk alleles were specifically enriched in active enhancers of monocytes, macrophages, and microglia.
    [Nature Communications]

    Full Article

    Schwann Cell Plasticity Regulates Neuroblastic Tumor Cell Differentiation via Epidermal Growth Factor-Like Protein 8

    Researchers investigated whether stromal Schwann cells in benign-behaving peripheral neuroblastic tumors adopted a similar cellular state.
    [Nature Communications]

    Full ArticlePress Release

    S-Nitrosylated TDP-43 Triggers Aggregation, Cell-to-Cell Spread, and Neurotoxicity in hiPSCs and In Vivo Models of ALS/FTD

    The authors showed environmentally induced nitrosative stress triggered protein aggregation and cell-to-cell spread.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Brainstem Local Microglia Induce Whisker Map Plasticity in the Thalamus after Peripheral Nerve Injury

    Investigators showed the role of region-specific microglia in the brainstem principal trigeminal nucleus, a whisker sensory-recipient region, in ventral posteromedial nucleus whisker map plasticity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Synaptotagmin-1 Interacts with PI(4,5)P2 to Initiate Synaptic Vesicle Docking in Hippocampal Neurons

    Scientists showed that in mouse hippocampal synapses, synaptic vesicle (SV) docking initiates at ∼12 nm to the active zone by Synaptotagmin-1 (Syt1). They also demonstrated that PI(4,5)P2 was the membrane partner of Syt1 to initiate SV docking, and disrupting their interaction could abolish the docking initiation.
    [Cell Reports]

    Full Article

    EGFRvIII Tumorigenicity Requires PDGFRA Co-Signaling and Reveals Therapeutic Vulnerabilities in Glioblastoma

    Investigators report that EGFRvIII demonstrated a reliance on PDGFRA co-stimulatory signaling during the tumorigenic process in a genetically engineered autochthonous glioblastoma model.
    [Oncogene]

    Abstract

    CDK8 Maintains Stemness and Tumorigenicity of Glioma Stem Cells by Regulating the C-MYC Pathway

    The authors demonstrated how cyclin-dependent kinase 8 (CDK8) played an essential role in maintaining stemness and tumorigenicity in glioma stem cells.
    [Oncogene]

    Abstract

    Overexpression of Annexin A2 Promotes Proliferation by Forming a Glypican 1/C-Myc Positive Feedback Loop: Prognostic Significance in Human Glioma

    Researchers found that Annexin A2 (ANXA2)-induced glioma cell proliferation in a c-Myc-dependent manner. ANXA2 increased the expression of Glypican 1 (GPC1) via c-Myc and the upregulated GPC1 further promoted the c-Myc level, forming a positive feedback loop, which led to enhanced proliferation of glioma cells.
    [Cell Death & Disease]

    Full Article

    Rewiring of Purine Metabolism in Response to Acidosis Stress in Glioma Stem Cells

    Investigators cultured glioma stem cells at pH 6.8 and pH 7.4 and found that cells cultured at low pH exhibited increased de novo purine nucleotide biosynthesis activity.
    [Cell Death & Disease]

    Full Article

    He knew neuronal cultures should be active. So he invented a new medium. Watch Cedric Bardy's webinar.
    REVIEWS

    Is LRRK2 the Missing Link between Inflammatory Bowel Disease and Parkinson’s Disease?

    Scientists review how Parkinson’s disease and Crohn’s disease share overlapping phenotypes, particularly in terms of leucine-rich repeat kinase 2 (LRRK2) in the context of the immune system, which could be targeted in future therapies.
    [npj Parkinson’s Disease]

    Full Article

    BRD4: An Emerging Prospective Therapeutic Target in Glioma

    The authors discuss the progress in the use of BRD4 inhibitors for glioma treatment, their mechanism of action, and their broad potential clinical application.
    [Molecular Therapy-Oncolytics]

    AbstractFull ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Boehringer Ingelheim and The Lieber Institute for Brain Development to Collaborate to Develop Centrally Acting COMT Inhibitors for Treatment of Neuropsychiatric Disorders

    Boehringer Ingelheim and the Lieber Institute for Brain Development announced a joint research and licensing collaboration focused on the development of novel centrally acting catechol-O-methyltransferase (COMT) inhibitors for the potential treatment of cognitive deficits in a spectrum of neuropsychiatric disorders, including schizophrenia.
    [Boehringer Ingelheim]

    Press Release

    Alchemab and Medicines Discovery Catapult to Develop Landmark Novel Antibody Therapy for Huntington’s Disease

    Alchemab has been awarded a UK Biomedical Catalyst early award grant from Innovate UK to support the development of a novel disease-modifying antibody therapy for Huntington’s disease.
    [Alchemab]

    Press Release

    FEATURED EVENT

    Wisconsin Stem Cell Symposium: The Single Cell Revolution in Stem Cells

    April 14, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Centre for Discovery Brain Sciences

    University of Edinburgh – Edinburgh, England, United Kingdom

    Faculty Position – Brain Immunology and Glia

    University of Virginia – Charlottesville, Virginia, United States

    Postdoctoral Fellowship – Vascular Inflammation and Cognitive Function

    University of Ottawa – Ottawa, Ontario, Canada

    Postdoctoral Researcher – Circuit Neuroscience

    DZNE – Bonn, Germany

    Postdoctoral Fellow – Neuropathology

    Johns Hopkins University School of Medicine – Baltimore, Maryland. United States

    > See All Jobs

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