Neural Cell News Volume 15.25 | Jun 30 2021

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    2021-06-30 | NCN 15.25


    Neural Cell News by STEMCELL Technologies
    Vol. 15.25 – 30 June, 2021
    TOP STORY

    Cerebellar Granule Cell Axons Support High-Dimensional Representations

    To examine sensorimotor representations from the point of view of downstream Purkinje cell ‘decoders’, investigators used three-dimensional acousto-optic lens two-photon microscopy to record from hundreds of cerebellar granule cell axons.
    [Nature Neuroscience]

    Abstract

    Learn about brain-region-specific organoids in an on-demand webinar with Dr. Sergiu Paşca
    PUBLICATIONSRanked by the impact factor of the journal

    HepaCAM Controls Astrocyte Self-Organization and Coupling

    Researchers identified a molecular mechanism regulating astrocyte-astrocyte interactions during development to coordinate astrocyte morphogenesis and gap junction coupling.
    [Neuron]

    Abstract

    Conservation and Divergence of Vulnerability and Responses to Stressors between Human and Mouse Astrocytes

    Based on analyses of acutely purified astrocytes, serum-free cultures of primary astrocytes, and xenografted chimeric mice, scientists found extensive conservation in astrocytic gene expression between human and mouse samples.
    [Nature Communications]

    Full Article

    Neuronal and Glial 3D Chromatin Architecture Informs the Cellular Etiology of Brain Disorders

    Researchers integrated genome-wide chromosome conformation data from purified neurons and glia with transcriptomic and enhancer profiles, to characterize the gene regulatory landscape of two major cell classes in the human brain.
    [Nature Communications]

    Full Article

    Restoration of the Molecular Clock Is Tumor Suppressive in Neuroblastoma

    Scientists found that MYCN induced the expression of clock repressors and downregulated one of the clock activators by directly binding to their promoters
    [Nature Communications]

    Full Article

    SETBP1 Accumulation Induces P53 Inhibition and Genotoxic Stress in Neural Progenitors Underlying Neurodegeneration in Schinzel-Giedion Syndrome

    Schinzel-Giedion syndrome neural progenitors exhibited aberrant proliferation, deregulation of oncogenes and suppressors, unresolved DNA damage, and resistance to apoptosis.
    [Nature Communications]

    Full Article

    Resolving Cell State in iPSC-Derived Human Neural Samples with Multiplexed Fluorescence Imaging

    Researchers applied PRobe-based Imaging for Sequential Multiplexing to facilitate multiplexed imaging with facile, rapid exchange of imaging probes to analyze induced pluripotent stem cells-derived cortical and motor neuron cultures that were relevant to psychiatric and neurodegenerative disease models, using over ten protein targets.
    [Communications Biology]

    Full Article

    Differences in In Vitro Microglial Accumulation of the Energy Metabolism Tracers [18F]FDG and [18F]BCPP-EF during LPS- and IL4 Stimulation

    Scientists evaluated lipopolysaccharide (LPS)- and interleukin 4 (IL4)-stimulated microglial uptake of 2DG and BCPP-EF to give a new insight into the hypothesis that different uptake of FDG and BCPP-EF could be ascribed to the different metabolic pathways activated during microglial activation.
    [Scientific Reports]

    Full Article

    The Neurodynamic Treatment Induces Biological Changes in Sensory and Motor Neurons In Vitro

    Investigators defined in vitro whether neurodynamic treatment protocols could induce selective biological effects on sensory and motor neurons, also investigating the possible involved molecular mechanisms taking a role behind this change.
    [Scientific Reports]

    Full Article

    Microglial Signaling Pathway Deficits Associated with the Patient Derived R47H TREM2 Variants Linked to AD Indicate Inability to Activate Inflammasome

    Apoptotic cell phagocytosis and soluble triggering receptor on myeloid cells 2 (TREM2) shedding were unaltered, suggesting a disjoint between the pathways and the signaling cascades downstream of TREM2 in R47H-expressing induced pluripotent stem cell-derived microglia (iPS-Mg), whilst metabolic deficits in glycolytic capacity and maximum respiration were reversed when R47H expressing iPS-Mg were exposed to phosphatidylserine+ expressing cells.
    [Scientific Reports]

    Full Article

    Reporter Cell Assay for Human CD33 Validated by Specific Antibodies and Human iPSC-Derived Microglia

    Variants of CD33 were associated with Alzheimer’s disease (AD) suggesting that modulation of CD33 signaling might be beneficial in AD. Scientists developed a reliable cellular CD33 reporter systems.
    [Scientific Reports]

    Full Article

    Explore scientific events this July with the Science Events Calendar.
    REVIEWS

    Quantitative Magnetic Resonance Imaging of Brain Anatomy and In Vivo Histology

    The understanding of magnetic resonance imaging (MRI) tissue contrast provided by histology using MRI is, in turn, crucial for further improvements of quantitative MRI, and they should be considered closely interlinked. Scientists discuss concepts, models and validation approaches, pointing out challenges and the latest advances in this field.
    [Nature Reviews Physics]

    Abstract

    INDUSTRY AND POLICY NEWS

    Anova Partners with NeOnc Technologies to Bring NEO100 to Patients with IDH1 Mutated Gliomas

    Anova Enterprises, Inc. announced a partnership with the NeOnc Technologies, Inc. to accelerate the development of NEO100 for patients with IDH1 mutated gliomas.
    [Anova, Inc.]

    Press Release

    Embera NeuroTherapeutics Announces First Subject Dosed in Phase IIa Study of EMB-001 in Smoking Cessation

    Embera NeuroTherapeutics, Inc., announced that the first subject has been dosed in a Phase IIa smoking cessation study for the treatment of tobacco use disorder.
    [Embera NeuroTherapeutics, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    GammaDelta T Therapies Summit

    July 27 – 29, 2021
    Virtual

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    JOB OPPORTUNITIES

    Faculty Position – Computational Neuroscience

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Research Associate – Electrophysiology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship Position – Post-Stroke Recovery

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Associate – Biopsychology

    Technische Universität Dresden – Dresden, Germany

    Postdoctoral Scholar – Neuroscience and Metabolism

    Oregon Health and Science University – Portland, Oregon, United States

    > See All Jobs

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