Neural Cell News Volume 15.29 | Jul 28 2021

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    Justin.choi
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    2021-07-28 | NCN 15.29


    Neural Cell News by STEMCELL Technologies
    Vol. 15.29 – 28 July, 2021
    TOP STORY

    ELAVL4, Splicing, and Glutamatergic Dysfunction Precede Neuron Loss in MAPT Mutation Cerebral Organoids

    Scientists used human induced pluripotent stem cell-derived cerebral organoids expressing tau-V337M and isogenic corrected controls to discover early alterations because of the mutation that precede neurodegeneration.
    [Cell]

    AbstractGraphical Abstract

    Organoids: Nature Research Round Table
    PUBLICATIONSRanked by the impact factor of the journal

    Simultaneous Disruption of PRC2 and Enhancer Function Underlies Histone H3.3-K27M Oncogenic Activity in Human Hindbrain Neural Stem Cells

    Researchers used human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context.
    [Nature Genetics]

    Abstract

    Exosomal miR-101-3p and miR-423-5p Inhibit Medulloblastoma Tumorigenesis through Targeting FOXP4 and EZH2

    An in vitro functional analysis of miR-101-3p and miR-423-5p showed that treating medulloblastoma cells with the corresponding mimics significantly inhibited the proliferation, colony-forming ability, migratory ability, and invasive capacity of tumor cells, and promoted cell apoptosis.
    [Cell Death & Differentiation]

    Full Article

    ERBB3 Overexpression Due to miR-205 Inactivation Confers Sensitivity to FGF, Metabolic Activation, and Liability to ERBB3 Targeting in Glioblastoma

    Investigators identified a human glioblastoma subset characterized by ERBB3 overexpression and nuclear accumulation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dysregulation of the AP2M1 Phosphorylation Cycle by LRRK2 Impairs Endocytosis and Leads to Dopaminergic Neurodegeneration

    Scientists explored the molecular mechanism linking LRRK2 to endocytosis and found that LRRK2 bound to and phosphorylated the μ2 subunit of the adaptor protein AP2 (AP2M1), a core component of the clathrin-mediated endocytic machinery.
    [Science Signaling]

    Abstract

    GRP78 Determines Glioblastoma Sensitivity to UBA1 Inhibition-Induced UPR Signaling and Cell Death

    The authors evaluated the functional activity and mechanism of TAK-243 in preclinical models of glioblastoma multiforme.
    [Cell Death & Disease]

    Full Article

    MicroRNA-361-5p Slows Down Gliomas Development through Regulating UBR5 to Elevate ATMIN Protein Expression

    Loss/gain-of-function method was applied to determine the roles of miR-361-5p and UBR5 in gliomas, as to cell viability, migration, invasion, colony formation ability, and apoptosis in vitro and tumorigenesis in vivo.
    [Cell Death & Disease]

    Full Article

    Modest Changes in Spi1 Dosage Reveal the Potential for Altered Microglial Function as Seen in Alzheimer’s Disease

    Investigators determined how the microglial transcriptome was altered following modest changes to Spi1 expression in primary mouse microglia.
    [Scientific Reports]

    Full Article

    Elevated Cellular PpIX Potentiates Sonodynamic Therapy in a Mouse Glioma Stem Cell-Bearing Glioma Model by Downregulating the Akt/NF-κB/MDR1 Pathway

    In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
    [Scientific Reports]

    Full Article

    Microfabricated Disk Technology: Rapid Scale Up in Midbrain Organoid Generation

    Scientists developed a method with microfabricated disks to scale up the generation of human midbrain organoids.
    [Methods]

    Full Article

    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Alpha-Synuclein Research: Defining Strategic Moves in the Battle against Parkinson’s Disease

    The authors succinctly summarize the critical features that define α-synuclein’s varied roles and identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in Parkinson’s disease.
    [npj Parkinson’s Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    VoxNeuro Receives Health Canada Class II Medical Device Designation

    VoxNeuro, Inc. has received Health Canada Class II Medical Device designation for its proprietary Cognitive Health Assessment Management Platformâ„¢. VoxNeuro will begin rolling out the software as a medical device across its Canadian Test Centers.
    [VoxNeuro, Inc. (Postmedia Network, Inc.)]

    Press Release

    Synchron Receives Green Light from FDA to Begin Breakthrough Trial of Implantable Brain Computer Interface in US

    Synchron, Inc. announced that the US FDA has approved its Investigational Device Exemption application for its flagship product, the Stentrodeâ„¢ motor neuroprosthesis.
    [Synchron, Inc.]

    Press Release

    FEATURED EVENT

    6th European Congress of Immunology

    September 1 – 4, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Translational Brain Research

    German Cancer Research Center – Heidelberg, Germany

    Postdoctoral Researcher – Electrophysiology of Neural Circuits with Gene Therapy

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Researcher – Tumorigenesis in Melanoma and Glioblastoma

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    PhD/Postdoctoral Position – Astrocytes in Cortical Plasticity

    Flanders Institute for Biotechnology – Leuven, Belgium

    Faculty Position – Computational Neuroscience

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    > See All Jobs

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